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Breast Cancer clinical trials

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NCT ID: NCT03524248 Suspended - Breast Cancer Clinical Trials

Development of Real-time Image-guided Radiotherapy

Start date: May 17, 2012
Phase: N/A
Study type: Interventional

The goal is to achieve the maximal radiotherapy tumor dose while sparing the health tissue and critical structures. On-board cone-beam CT (CBCT) scans are routinely acquired prior to dose delivery and matched with simulation CT at the planned treatment positions. Thus, setup or motion errors can be detected and corrected. However, CBCT is not available for situations with gantry collisions such as WBI and TSEB. More importantly, CBCT cannot reveal any irregular respiration or body movement during beam-on time. Thus, it is essential to develop a real-time image system that can detect organ/body motion during beam-on time, and correlate simulation-planning images with prior treatment CBCT images.In this proposed clinical trial, we will cooperate with a 3D camera company (Xigen LLC) to develop novel 4D video imaging techniques and validate the feasibility and accuracy of 4D video image guidance in correlation with 4D CT/CBCT useful for advanced IGRT.

NCT ID: NCT03393741 Suspended - Breast Cancer Clinical Trials

Pharmacodynamic Biomarkers of Standard Anti-microtubule Drugs as Assessed by Early Tumor Biopsy

Start date: January 29, 2018
Study type: Observational

Eligible subjects will be assigned to study treatment arms by their treating oncologist, rather than by the study. The drug, dose, and schedule of administration will be determined by the treating physician per NCCN guidelines for standard of care chemotherapy regimens for recurrent or metastatic breast cancer. Study treatment arms include: Taxane (nab-paclitaxel or paclitaxel), Eribulin, Vinorelbine, Ixabepilone, or the control arm (non-microtubule targeted chemotherapies such as doxorubicin, carboplatin, or gemcitabine).

NCT ID: NCT03340402 Suspended - Breast Cancer Clinical Trials

Preoperative Accelerated Partial Breast Irradiation for Triple Negative Breast Cancer Using Proton Beam Scanning

Start date: December 7, 2017
Phase: N/A
Study type: Interventional

This research study is studying an intervention as a possible treatment for Triple Negative Breast Cancer.

NCT ID: NCT03301350 Suspended - Breast Cancer Clinical Trials

Neoadjuvant Carbo/Paclitaxel Followed by Doxorubicin/Cyclophosphamide in Breast Cancer

Start date: November 7, 2017
Phase: Phase 2
Study type: Interventional

This is a phase II single-arm, open-label, prospective study to evaluate the efficacy of the low dose weekly Carboplatin/Paclitaxel followed by dose-dense Doxorubicin/Cyclophosphamide in subjects with triple-negative breast cancer in neoadjuvant settings.

NCT ID: NCT02856503 Suspended - Breast Cancer Clinical Trials

Effect of High Dose Vitamin D on Cancer Biomarkers and Breast Cancer Tumors

Start date: January 2019
Phase: Phase 1/Phase 2
Study type: Interventional

High-doses of Vitamin D (VD) may be used as targeted therapy against breast cancer. The investigators will assess the effect of high dose VD on the following biomarkers in the breast cancer cells: VDR, estrogen receptor (ER), progesterone receptor (PR), epidermal growth factor receptor 2 (Her2/neu), androgen receptor (AR), as well as epidermal growth factor receptor 1 (EGFR) and Ki-67, as markers of proliferation, and E-cadherin, a marker of invasion and metastasis.

NCT ID: NCT02850419 Suspended - Breast Cancer Clinical Trials

Heat-Activated Target Therapy of Local-Regional Relapse in Breast Cancer Patients

Start date: n/a
Phase: Phase 2
Study type: Interventional

The 105-15-201 study is designed to assess the effectiveness and tolerability of the combination of heat-activated target therapy (radiotherapy + hyperthermia + lyso-thermosensitive liposomal doxorubicin) of loco-regional relapse in breast cancer patients.

NCT ID: NCT02313116 Suspended - Breast Cancer Clinical Trials

Computed Optical Margin Assessment for Breast Cancer Surgery, Phase I (Part B)

Start date: April 2014
Phase: N/A
Study type: Observational

This intraoperative study is a prospective study analyzing specimens from fifty subjects. Patients scheduled to undergo breast-conserving surgery will be recruited in accordance with the inclusion and exclusion criteria. The study period per subject is the time it takes to assess the ex vivo breast tissue sample using the study device. Image review will be conducted during surgery and compared to the margin status findings in the post-operative pathology report.

NCT ID: NCT02137837 Suspended - Breast Cancer Clinical Trials

S1222 Trial (Everolimus, Anastrozole and Fulvestrant) in Post-Menopausal Stage IV Breast Cancer

Start date: May 2014
Phase: Phase 3
Study type: Interventional

This randomized Phase III trial studies how well the combination of fulvestrant and everolimus together or the combination of anastrozole, fulvestrant and everolimus together, improve progression-free survival (PFS) versus fulvestrant alone.

NCT ID: NCT02127073 Suspended - Breast Cancer Clinical Trials

Pilot Study of Oxytocin and microRNA Identification in NAF, Serum, and Tissue in Women With Breast Cancer

Start date: March 2014
Phase: Phase 2
Study type: Interventional

The purpose of this study is to examine the genetic material called microRNA of three types of specimens from women with breast cancer. The study also seeks to examine the effectiveness of using a new agent called oxytocin to increase the amount of nipple fluid that can be collected during surgery.

NCT ID: NCT02062983 Suspended - Breast Cancer Clinical Trials

Early Predictor of Herceptin Cardio Toxicity in Breast Cancer Patients

Start date: June 2012
Phase: N/A
Study type: Observational

Early identification of patients at risk for cardiotoxicity represent a primary goal for cardiologist and oncologist From all adjuvant trials echocardiography is ideal for evaluating Left Ventricular function though its operator dependent. The use of other technique such as endomyocardial biopsy, is troublesome in clinical practice Cardiac magnetic resonance imaging (MRI) have greater reproducibility in evaluating left ventricular ejection fraction (LVEF). This technique provides morphological, functional, perfusion, and viability information in one assessment. It is expensive and time consuming but id the diagnostic method of choice for patients with technically limited images from ECG and in patients with discordant information that is clinically significant from prior tests