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Breast Cancer clinical trials

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NCT ID: NCT03126487 Withdrawn - Breast Cancer Clinical Trials

High Intensity Focused Ultrasound Guided by MRI as Thermic Destruction in Primitive Small Size Breast Cancer

MRHEATBREAST
Start date: April 25, 2017
Phase: N/A
Study type: Interventional

This is a non-randomized, prospective phase II trial evaluating an innovative treatment, focused MRI-guided ultrasound, as thermic destruction in primitive small size breast cancer.

NCT ID: NCT03081234 Withdrawn - Breast Cancer Clinical Trials

Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- Intermediate Risk Early Breast Cancer

EarLEE-2
Start date: March 31, 2018
Phase: Phase 3
Study type: Interventional

This is an international, multi-center, randomized, double-blinded, placebo-controlled clinical study evaluating the efficacy and safety of ribociclib with endocrine therapy as an adjuvant treatment in patients with hormone receptor-positive, HER2-negative, intermediate risk breast cancer.

NCT ID: NCT02944721 Withdrawn - Breast Cancer Clinical Trials

Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic Pain After Surgery for Breast Cancer

DOLORISKSEIN
Start date: November 2016
Phase: N/A
Study type: Interventional

The aim of the study is to establish the genetic, neurophysiological and psychological phenotype of the patients presenting a persistent neuropathic pain after surgery of the breast cancer, by comparing the neuropathic painful patients with the not painful and with the not neuropathic painful . This will be realized on a transverse cohort ("Seintinelle"cohort) and confirmed on a forward-looking longitudinal cohort.

NCT ID: NCT02929576 Withdrawn - Breast Cancer Clinical Trials

Efficacy and Safety Study of Enzalutamide in Combination With Paclitaxel Chemotherapy or as Monotherapy Versus Placebo With Paclitaxel in Patients With Advanced, Diagnostic-Positive, Triple-Negative Breast Cancer

ENDEAR
Start date: September 2016
Phase: Phase 3
Study type: Interventional

The purpose of this study is to evaluate and compare the clinical benefit and safety of treatment with enzalutamide in combination with paclitaxel chemotherapy or as monotherapy versus placebo with paclitaxel in patients with locally advanced or metastatic, diagnostic-positive, triple-negative breast cancer (TNBC).

NCT ID: NCT02784730 Withdrawn - Breast Cancer Clinical Trials

Iterative PICC Placement Versus Long Term Device

PICC One Day
Start date: January 10, 2018
Phase: Phase 3
Study type: Interventional

Peripherally Inserted Central Catheter (PICC) and port-a-cath (PAC) are the most commonly medical devices used for the administration of chemotherapy. Placement of these devices via central venous access is sometimes responsible for complications. The incidence of these complications is correlated with the device holding time. A strategy of iterative PICC placement could significantly reduce these complications.

NCT ID: NCT02768714 Withdrawn - Breast Cancer Clinical Trials

Trial to Compare the Efficacy and Safety of Pegfilgrastim Biosimilar in Subjects With High Risk Stage Breast Cancer Receiving Chemotherapy

Start date: January 2018
Phase: Phase 3
Study type: Interventional

This is a Phase III, randomised, assessor-blind, parallel group, multicentre trial. At least 180 adult subjects with high-risk Stage II or Stage III / IV breast cancer will be randomised (1:1) to receive either Eurofarma's pegfilgrastim (n = 90) or Neulastim (n = 90) in 8 to 10 sites in Brazil. Subjects will undergo a maximum of 4 cycles of myelosuppressive chemotherapy (21 days per cycle).

NCT ID: NCT02759549 Withdrawn - Breast Cancer Clinical Trials

Fatigue in Breast Cancer Patients Undergoing Radiotherapy-eSMART-MH

Start date: September 2015
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if an avatar-based depression self-management intervention (eSMART-MH) once a week for the duration of the participant's radiation treatment will significantly reduce depressive symptoms. Investigators also seek to explore how women with breast cancer describe their mood using prompted and unprompted speech through electronic social media and interviews. Participants will be randomized into the eSMART-MH group or the theater testing (attention control) group. In addition to the assigned interventions, participants will be asked to complete questionnaires and interviews with the study staff.

NCT ID: NCT02752009 Withdrawn - Breast Cancer Clinical Trials

Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy

Start date: April 26, 2016
Phase: N/A
Study type: Interventional

This research protocol is studying the accuracy of the sentinel lymph node biopsy procedure in breast cancer patients who have cancer cells in the lymph nodes in the armpit (axilla) who have received chemotherapy or endocrine therapy prior to having surgery (neoadjuvant therapy).

NCT ID: NCT02725541 Withdrawn - Breast Cancer Clinical Trials

Trial of Neoadjuvant Trastuzumab Emtansine in Patients With HER2-Equivocal Breast Cancer

NATURE
Start date: March 2016
Phase: Phase 2
Study type: Interventional

This is an open label, neoadjuvant phase II study to evaluate the objective response, toxicity, and safety of trastuzumab emtansine in patients with newly diagnosed HER2-equivocal breast cancer. Trastuzumab emtansine at a dose of 3.6 mg/kg will be intravenously administered every 3 weeks for a total of 6 weeks. Patients who achieve a partial or complete response after the 6-week treatment (responders) will continue on trastuzumab emtansine for an additional 12 weeks.

NCT ID: NCT02685306 Withdrawn - Breast Cancer Clinical Trials

A Study of Neoadjuvant Paclitaxel in Combination With Bavituximab in Early- Stage Triple- Negative Breast Cancer

Start date: March 2016
Phase: Phase 2
Study type: Interventional

The primary purpose of this research study is to see whether adding bavituximab (an investigational drug) to the standard chemotherapy drug taxane, will improve the results of the treatment for early- stage Triple Negative Breast Cancer followed by Standard- of- Care surgery