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Breast Cancer clinical trials

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NCT ID: NCT03501693 Enrolling by invitation - Breast Cancer Clinical Trials

Fujifilm DBT Plus S-View Versus FFDM Alone in the Detection of Breast Cancer - A Pivotal Study

Start date: April 6, 2018
Phase: N/A
Study type: Interventional

The purpose of the pivotal reader study is to assess the comparative accuracy of Fujifilm DBT plus S-View versus FFDM in the detection of breast cancer.

NCT ID: NCT03476226 Enrolling by invitation - Breast Cancer Clinical Trials

Cognitive Dysfunction and Breast Cancer Coping Strategies Impact on QOL

Start date: November 18, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to determine whether patients experience a better quality of life when they have received education about coping strategies for cognitive dysfunction.

NCT ID: NCT03407040 Enrolling by invitation - Breast Cancer Clinical Trials

Generation of Cancer Antigen-Specific T-cells From Human Induced Pluripotent Stem Cells (iPSC) for Research and Potential FutureTherapy

Start date: January 30, 2018
Phase: N/A
Study type: Observational

Background: Researchers want to test if certain cells can be re-programmed into stem cells. Stem cells can keep reproducing for a long time. Cells made by stem cells can be turned into different types of cells. These include cancer-fighting cells, skin cells, etc. The stem cells generated in this study will be used to make specific tumor-fighting cells that can recognize different types of mutations in cancer cells. They may also help identify new tumor mutations that may not have been identified yet. Objectives: To test if a certain type of tumor-fighting cells can be re-programmed into stem cells. Eligibility: Participants in another Surgery Branch protocol who are at least 16 years old Design: Participants already gave samples of blood and/or tumor tissue in the other protocol. They do not need to come back to the clinic or give any other samples. Participants will give consent for their samples to be used in this study. Researchers will obtain cells from the samples. They will grow those cells in the lab. They will create stem cells from them. Researchers will do genetic tests on the samples. Most tests will not show important health results. But if they do, the participant will be invited to talk to a genetic counselor and get more detailed testing to confirm the results. Some of the samples and results will be stored indefinitely. They may be used in future research. No personal information will be stored with them.

NCT ID: NCT03384992 Enrolling by invitation - Breast Cancer Clinical Trials

Targeted eHealth Intervention to Reduce Fear of Recurrence Among Breast Cancer Survivors

FoRtitude
Start date: March 2014
Phase: N/A
Study type: Interventional

The FoRtitude trial aims to evaluate an eHealth intervention designed to teach breast cancer survivors strategies to manage anxiety about cancer recurrence. The eHealth intervention includes educational content and interactive tools, designed to teach coping strategies and/or inert content, depending on the study participant's randomization assignment. The FoRtitude study will examine whether three coping strategies (relaxation training, cognitive restructuring, worry practice) are more effective than general health-related content in reducing fear of cancer recurrence.

NCT ID: NCT03294330 Enrolling by invitation - Breast Cancer Clinical Trials

SPY-X: A Study to Assess the Feasibility of Using SPY Alone for Sentinel Node Localization for Melanoma or Breast Cancer

SPYX
Start date: October 11, 2017
Phase: Phase 3
Study type: Interventional

The objective of this study is to determine if fluorescence lymphangiography can be used alone to localize sentinel nodes in patients with melanoma or breast cancer. The hypothesis is that sentinel nodes can be identified using only indocyanine green (ICG) and fluorescence lymphangiography, without the need for technetium99 and a gamma probe.

NCT ID: NCT03136367 Enrolling by invitation - Breast Cancer Clinical Trials

What Matters Most: Choosing the Right Breast Cancer Surgery for You

Start date: September 18, 2017
Phase: N/A
Study type: Interventional

What Matters Most is a study that aims to determine how best to help women of lower socioeconomic status make high-quality decisions about early stage breast cancer treatments. What Matters Most will be comparing two decision aids used in the clinic visit to usual care (what normally happens in the clinic). The first decision aid (Option Grid) presents evidence-based information about lumpectomy and mastectomy in a tabular format using text only. The second decision aid (Picture Option Grid) presents evidence-based information about lumpectomy and mastectomy using pictures, pictographs and simplified text. What Matters Most aims to show that the interventions can reduce disparities in decision-making and treatment choice between women of high and low SES.

NCT ID: NCT03116035 Enrolling by invitation - Breast Cancer Clinical Trials

Impact of Pre-Operative Web-based Breast Cancer Information on the Quality of Patient Decision-Making

Start date: April 24, 2014
Phase: N/A
Study type: Interventional

This is a prospective randomized control trial to compare the impact of two different types of pre-operative web-based breast cancer information on the quality of patient decision making. Patients are emailed web-based information prior to the surgical consultation. Outcomes are assess at multiple time points: 1) prior to the surgical consultation, 2) immediately following the consultation.

NCT ID: NCT03070236 Enrolling by invitation - Breast Cancer Clinical Trials

PORTAL: Patient-reported Outcomes After Routine Treatment of Atypical Lesions

Start date: December 1, 2017
Phase: N/A
Study type: Interventional

This research study is evaluating how patients feel physically and emotionally after a prior breast biopsy for specific breast conditions (including atypical lesions such as atypical ductal hyperplasia (ADH), atypical lobular hyperplasia (ALH), lobular carcinoma in situ (LCIS), and/or ductal carcinoma in situ (DCIS))

NCT ID: NCT02980848 Enrolling by invitation - Breast Cancer Clinical Trials

Assessing Breast Density's Value in Imaging - A Comparative Effectiveness Study

BCSC-ADVANCE
Start date: September 2016
Phase: N/A
Study type: Observational [Patient Registry]

This Beast Cancer Surveillance Consortium (BCSC) ADVANCE study is a large, observational pragmatic comparative effectiveness research study using high-quality, prospectively collected data from BCSC registries to generate evidence on how breast density should be integrated into decision making around breast cancer screening and preoperative diagnostic work-up. We will augment existing BCSC registry infrastructure with additional prospective data collection and collection of patient reported outcomes (PROs), CISNET modeling of long-term screening outcomes, and qualitative data from focus groups with women represented in two aims.

NCT ID: NCT02955940 Enrolling by invitation - Breast Cancer Clinical Trials

An Open-Label Study to Enable Continued Treatment Access for Subjects Previously Enrolled in Studies of Ruxolitinib

Start date: November 2016
Phase: Phase 2
Study type: Interventional

The purpose of this study is to provide continued supply of ruxolitinib alone, ruxolitinib plus background cancer therapy, or background cancer therapy alone to subjects from an Incyte-sponsored study of ruxolitinib that has reached its study objectives or has been terminated. This study will also provide another mechanism for reporting adverse events related to study drug safety.