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Breast Cancer clinical trials

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NCT ID: NCT03768258 Completed - Breast Cancer Clinical Trials

Testosterone Implants and the Incidence of Breast Cancer

Start date: March 2008
Study type: Observational

This current chart review study was designed to investigate the incidence of breast cancer in women treated with subcutaneous testosterone therapy for symptoms of hormone deficiency.

NCT ID: NCT03762642 Completed - Breast Cancer Clinical Trials

Trends of Mastectomy and Breast-Conserving Surgery in Female Breast Cancer Patients

Start date: July 17, 2017
Study type: Observational

Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide. The survival rates are markedly lower in the developing countries compared to developed countries, as well as the age at diagnosis. Core management of breast cancer includes surgical removal of the tumor either by breast-conserving surgery (BCS) or mastectomy (removal of the whole breast). Choosing between these two procedures may be influenced by factors that have yet to be studied in Saudi Arabia. The investigators aimed to determine the prevalence of BCS and mastectomy and the factors that may influence the choice of procedure. This retrospective study was carried out by reviewing the records of female breast cancer patients who underwent BCS or mastectomy at King Abdulaziz University Hospital between 2009 to June 2017, excluding those with metastasis (distant spread of the cancer) or recurrence. Using frequencies for the rate, and multivariate tests, the investigators analyzed different demographic, clinicopathological, and radiological factors to detect correlations with procedure choice.

NCT ID: NCT03754816 Completed - Breast Cancer Clinical Trials

The Combination of PECS II Block and Parasternal Block for Radical Mastectomy

Start date: October 16, 2016
Phase: N/A
Study type: Interventional

The combination of PECS II and parasternal Block provides analgesia after radical mastectomy

NCT ID: NCT03712696 Completed - Breast Cancer Clinical Trials

Efficacy and Safety of DIGNICAP™ System

Start date: July 18, 2014
Phase: N/A
Study type: Interventional

Chemotherapy-induced alopecia (CIA) is one of the most common and emotionally distressing side effects of cancer therapy. In this study we sought to assess the feasibility and the effectiveness of scalp cooling system DigniCap® to prevent alopecia in primary breast cancer patients receiving an anthracycline containing adjuvant chemotherapy (CT). A prospective two-stage design clinical trial conducted at a single Institution of women with primary breast cancer scheduled to receive anthracycline with or without taxane-based adjuvant CT. Patients were enrolled from July 2014 to November 2016, with ongoing annual follow up for 5 years. The scalp cooling period initiated approximately 30 minutes before CT. Scalp temperature was to be maintained at 3-5°C throughout CT and for 90 to 120 minutes afterward, depending on the CT drug and dose.

NCT ID: NCT03708432 Completed - Breast Cancer Clinical Trials

500mg Fulvestrant in HR+ MBC

Start date: July 15, 2017
Study type: Observational

To study the real world use of 500mg Fulvestrant in HR+ MBC.

NCT ID: NCT03698942 Completed - Breast Cancer Clinical Trials

Delphinus SoftVue™ ROC Reader Study

Start date: September 23, 2018
Study type: Observational

The purpose of this multi‐reader, multi‐case (MRMC) reader study is to evaluate reader performance when SoftVue™ automated breast ultrasound and screening mammography are combined, compared to screening mammography alone, in women with dense breast parenchyma. This includes obtaining information that can be used to properly plan, design, and power future ROC reader studies. This reader study will include a minimum of 6 radiologist readers and an enriched sample of at least 100 breast screening or diagnostic cases to be selected from the library of images collected under Delphinus Protocol #DMT‐2015.001 (NCT03257839). The reader study image case set will be enriched with cancer cases.

NCT ID: NCT03652935 Completed - Breast Cancer Clinical Trials

Mindfulness, Breast Cancer and Psycho-Immune Dysregulation

Start date: September 15, 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the benefits of a Mindfulness Based Stress Reduction (MBSR) program for psycho-immune dysregulation in women newly diagnosed with breast cancer compared to women with breast cancer completing an attention control condition (health education classes). Women will be randomized to either the MBSR or health education classes. They will complete psychometric instruments evaluating psychological outcomes and will provide blood samples for immune outcomes. They will also provide saliva samples for cortisol diurnal rhythm determination. Measures will be done longitudinally pre and post MBSR or health education program. It is hypothesized that MBSR participants will exhibit improved psychological and immunological outcomes over time, as compared to women randomized to the health education classes.

NCT ID: NCT03615430 Completed - Breast Cancer Clinical Trials

Serratus Plane Block in Preventing Postoperative Pain of Mastectomy

Start date: June 1, 2016
Phase: N/A
Study type: Interventional

A prospective, double-blinded randomized controlled, 1-year follow-up study was designed to compare the analgesic effect of serratus plane block (SPB) after breast cancer surgery. Women undergoing radical mastectomy were dIvided into Control group and SPB group. The postoperative acute pain was evaluated by numerical rating scale (NRS) and the effect of preventing chronic pain was assessed at 3, 6, 12 months after surgery by NRS.

NCT ID: NCT03612934 Completed - Breast Cancer Clinical Trials

The Impact of SPC on Advanced Breast Cancer Patients

Start date: May 1, 2015
Study type: Observational

The aim of this prospective, observational study is the evaluation of the effectiveness of a 14-day Specialist Palliative Care therapy in participants with advanced breast cancer carried out in a stationary palliative care unit in Poland. The length of the entire study will be 36 months.

NCT ID: NCT03604939 Completed - Breast Cancer Clinical Trials

Improving Access to Control of Diseases for Women

Start date: January 1, 2017
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the feasibility and acceptability of the model of delivering CHW-driven home-based comprehensive NCD control services aimed to prevent premature deaths from cardio-vascular diseases, stroke and breast, cervix and oral cancers in the hard-to-reach women.