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Breast Cancer clinical trials

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NCT ID: NCT03844685 Completed - Breast Cancer Clinical Trials

Red Clover and Lifestyle Changes to Contrast Menopausal Symptoms in Premenopausal Breast Cancer Patients Given Tamoxifen

Start date: July 5, 2012
Phase: Phase 2
Study type: Interventional

A prospective double-blind randomized trial of red clover extract (Promensil) vs placebo in surgically-treated premenopausal women with estrogen receptor-positive breast cancer taking tamoxifen

NCT ID: NCT03799757 Completed - Breast Cancer Clinical Trials

Using Bupivacaine Locally in the Mastectomy Drains to Control Postoperative Pain

Start date: January 2016
Phase: Phase 4
Study type: Interventional

in this study we are investigating the role of instillation of Bupivacaine through surgical drains at the end of mastectomy surgeries in controlling post operative pain and decreasing their pain killers requirement in the early postoperative period

NCT ID: NCT03788187 Completed - Breast Cancer Clinical Trials

Persistant Organics Pollutants in Breast Cancer.

Start date: August 2013
Phase: N/A
Study type: Interventional

Persistant Organics Pollutants (POP) accumulate in the adipose tissue (AT) and could modulate tumor progression as part of the microenvironment. The investigators tested the hypothesis that POPs exposure may be associated with breast cancer metastasis analyzing the concentrations of 46 POPs in both adipose tissue and serum samples from breast tumor patients (benign, malignant with and without lymph node metastasis)

NCT ID: NCT03772197 Completed - Breast Cancer Clinical Trials

Parallel Comparison of 18 Gene Classifiers and Oncotype DX (Nanostring)

Start date: June 1, 2018
Study type: Observational

A recurrence index for distant recurrence (RI-DR), an 18-gene-based clinical-genomic model, has been developed for early-stage breast cancer (EBC). In this study, Investigators compared the prognostic performance of the RI-DR with the Oncotype DX (ODx) recurrence score (RS) for any recurrence risk type.

NCT ID: NCT03768258 Completed - Breast Cancer Clinical Trials

Testosterone Implants and the Incidence of Breast Cancer

Start date: March 2008
Study type: Observational

This current chart review study was designed to investigate the incidence of breast cancer in women treated with subcutaneous testosterone therapy for symptoms of hormone deficiency.

NCT ID: NCT03762642 Completed - Breast Cancer Clinical Trials

Trends of Mastectomy and Breast-Conserving Surgery in Female Breast Cancer Patients

Start date: July 17, 2017
Study type: Observational

Breast cancer is the most common cancer in women across the world, accounting for 25.2% of cancer cases among females and 14.7% of cancer-related deaths among females worldwide. The survival rates are markedly lower in the developing countries compared to developed countries, as well as the age at diagnosis. Core management of breast cancer includes surgical removal of the tumor either by breast-conserving surgery (BCS) or mastectomy (removal of the whole breast). Choosing between these two procedures may be influenced by factors that have yet to be studied in Saudi Arabia. The investigators aimed to determine the prevalence of BCS and mastectomy and the factors that may influence the choice of procedure. This retrospective study was carried out by reviewing the records of female breast cancer patients who underwent BCS or mastectomy at King Abdulaziz University Hospital between 2009 to June 2017, excluding those with metastasis (distant spread of the cancer) or recurrence. Using frequencies for the rate, and multivariate tests, the investigators analyzed different demographic, clinicopathological, and radiological factors to detect correlations with procedure choice.

NCT ID: NCT03712696 Completed - Breast Cancer Clinical Trials

Efficacy and Safety of DIGNICAP™ System

Start date: July 18, 2014
Phase: N/A
Study type: Interventional

Chemotherapy-induced alopecia (CIA) is one of the most common and emotionally distressing side effects of cancer therapy. In this study we sought to assess the feasibility and the effectiveness of scalp cooling system DigniCap® to prevent alopecia in primary breast cancer patients receiving an anthracycline containing adjuvant chemotherapy (CT). A prospective two-stage design clinical trial conducted at a single Institution of women with primary breast cancer scheduled to receive anthracycline with or without taxane-based adjuvant CT. Patients were enrolled from July 2014 to November 2016, with ongoing annual follow up for 5 years. The scalp cooling period initiated approximately 30 minutes before CT. Scalp temperature was to be maintained at 3-5°C throughout CT and for 90 to 120 minutes afterward, depending on the CT drug and dose.

NCT ID: NCT03708432 Completed - Breast Cancer Clinical Trials

500mg Fulvestrant in HR+ MBC

Start date: July 15, 2017
Study type: Observational

To study the real world use of 500mg Fulvestrant in HR+ MBC.

NCT ID: NCT03698942 Completed - Breast Cancer Clinical Trials

Delphinus SoftVue™ ROC Reader Study

Start date: September 23, 2018
Study type: Observational

The purpose of this multi‐reader, multi‐case (MRMC) reader study is to evaluate reader performance when SoftVue™ automated breast ultrasound and screening mammography are combined, compared to screening mammography alone, in women with dense breast parenchyma. This includes obtaining information that can be used to properly plan, design, and power future ROC reader studies. This reader study will include a minimum of 6 radiologist readers and an enriched sample of at least 100 breast screening or diagnostic cases to be selected from the library of images collected under Delphinus Protocol #DMT‐2015.001 (NCT03257839). The reader study image case set will be enriched with cancer cases.

NCT ID: NCT03676127 Completed - Breast Cancer Clinical Trials

Diagnostic Accuracy of Dermal Thickness in Lymphedema

Start date: September 28, 2018
Study type: Observational

Ultrasound is an easily feasible noninvasive technique which is widely used in rehabilitation settings. Measurement of dermal thickness via ultrasound can be less time consuming than volume measurements with water displacement and circumference measurements. Measurement of subcutaneous tissue thickness were used for both assessment and treatment outcome. Recently reliability of ultrasound examination of thickness of the skin and subcutaneous tissue were studied by Han et al. However, diagnostic accuracy of this method has not been studied before. Early identification of breast cancer related lymphedema to start treatment earlier is critical. Consequently, reliability and diagnostic accuracy of the assessment techniques of lymphedema is crucial to evaluate both severity at the time of diagnosis, and later effectiveness of treatment. The aim of this study was to establish diagnostic accuracy of between side differences of ultrasonographic dermal thickness measurements in breast cancer related arm lymphedema.