Cardiovascular Diseases Clinical Trial
To investigate the relationship of vascular cell phenotypes to atherosclerosis.
BACKGROUND:
Currently, the predominant hypothesis regarding atherosclerosis is that it is in major part
driven by two independent pathways: hyperlipidemia (the "stimulation") and inflammation (the
"response"). Although vascular cells mediate the influence of inflammation on
atherosclerosis, very little is known about vascular cell epidemiology and the relationship
of vascular cell phenotypes to atherosclerosis. The main hypothesis tested in this study is
that variation in vascular cell biology is related to the population variation in
atherosclerosis.
DESIGN NARRATIVE:
The cross-sectional study will be nested within a large cohort study, the Multiethnic Study
of Atherosclerosis (MESA). A partial sample of 1,000 individuals who have undergone other
special laboratory analyses will be identified and new measures collected as part of their
upcoming site visit. A number of novel cellular phenotypes describing the innate immune
response (monocyte activation, natural killer and T cell counts), the adaptive immune
response (TH1 and TH2 helper cells, and memory T cells), and vessel integrity (circulating
endothelial progenitor cells) will be measured in these participants. Plasma constituents
will also be measured that relate to the cellular phenotypes. The overall goal is to test
the hypothesis that these novel phenotypes are associated with subclinical atherosclerosis
in the coronary and carotid arteries assessed by quantification of coronary calcification
(CAC) and B-mode ultrasound (CIMT), in addition to the other subclinical measures available
from the MESA cohort.
;
Observational Model: Cohort, Time Perspective: Cross-Sectional
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