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Stress Disorders, Traumatic clinical trials

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NCT ID: NCT01565213 Completed - Anxiety Disorders Clinical Trials

Transdiagnostic Group Treatments for Patients With Common Mental Disorders in Primary Health Care

Start date: January 2006
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effects of CBT and MMI on the quality of life and relief of psychological symptoms of patients with common mental disorders or problems attending primary health care centre.

NCT ID: NCT01564667 Completed - Clinical trials for Posttraumatic Stress Disorder

Attention Bias Modification Treatment for Warzone-Related Posttraumatic Stress Disorder (PTSD)

Start date: April 2012
Phase: N/A
Study type: Interventional

Veterans with Posttraumatic Stress Disorder (PTSD) will be randomly assigned to either Attention Bias Modification Treatment (ABMT) designed to reduce bias toward threat or a placebo control condition not designed to change attention patterns. Outcome measures will be PTSD, anxiety, depression, and alexithymia symptoms as measured by standard psychological interviews and questionnaires. Participants will also be invited to participate in physiological testing before and after receiving AMBT or placebo to serve as additional outcome measures and assess brain functioning, heart rate, and muscle tension. The investigators expect to see significant PTSD symptom reduction in the Attention Bias Modification Treatment (ABMT) group relative to the placebo control group in which no symptomatic relief is expected. At the end of the study, if ABMT is shown to be effective, we will offer active ABMT to those participants randomly assigned to the placebo arm if they would like to receive the treatment.

NCT ID: NCT01560728 Completed - Clinical trials for Post-Traumatic Stress Disorder

Bringing What Works to Youth in Corrections: A Trauma Intervention

Start date: November 2012
Phase: Phase 1/Phase 2
Study type: Interventional

Youth with mental illnesses are disproportionately represented in juvenile correctional facilities and limited evidence exists about effective treatments in this setting. This study will adapt Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), a treatment found to be efficacious in community settings, to the correctional setting and study the feasibility of its implementation. Conducted within Texas youth correctional facilities, the findings will be rapidly disseminated in the state. The goal is to enhance the TF-CBT approach to meet the unique needs of incarcerated youth and the correctional system, one of the priorities outlined in the National Institute of Mental Health Strategic Plan.

NCT ID: NCT01556074 Completed - Insomnia Clinical Trials

Evaluation of Yoga for Sleep Disturbances in Post Traumatic Stress Disorder (PTSD)

Start date: June 2012
Phase: N/A
Study type: Interventional

The primary objective of this preliminary study is to estimate sleep outcome effect sizes and determine feasibility for a novel yoga treatment of insomnia in participants with post traumatic stress disorder (PTSD). Additional objectives are to evaluate relationships of sleep outcomes with measures of other PTSD symptoms, psychosocial health and possible mechanisms of action.

NCT ID: NCT01556048 Completed - Clinical trials for Major Depressive Disorder

Pilot Study of Behavioral Activation for Prolonged Grief

Start date: February 2009
Phase: Phase 1
Study type: Interventional

The Institute of Medicine identifies Prolonged Grief (PG) as a critical under-addressed public health problem for which are no empirically supported treatments. The purpose of this application is to pilot-test Behavioral Activation (BA) therapy for PG. BA is a well supported, stand alone intervention for depression and recently applied to posttraumatic stress disorder, which reduces rumination and avoidance behaviors that otherwise thwart access to natural rewarding contingencies and resources. The treatment focuses on promoting stable, active routines, self-care behaviors, enhanced self-efficacy, and reengagement with pleasurable activities and significant social resources. Rumination, disengagement, and low self-efficacy are defining features of PG. Further, in response to loss of intimates, the key factors that differentiate resilient people from those that have difficulties adapting is the maintenance or fast resumption of social and occupational functioning. Thus, the main hypothesis of this study is that BA for PG will result in clinically significant reductions in rumination and functional disengagement. This is a preliminary small-scale pilot assessment of potential efficacy and feasibility of completing a large scale study of BA for PG.

NCT ID: NCT01554839 Completed - PTSD Clinical Trials

The Family of Heroes: an Evaluation of an Online Educational Tool

Start date: October 2011
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the effectiveness of a unique web based educational tool called "Family of Heroes," which is designed to educate families about Post Traumatic Stress Disorder (PTSD) and provide them with practical tools for interacting with affected veteran family members. The study includes veterans and a family member of their choosing. Participants are randomly assigned to a group which takes the online training or a group that does not take the training. Both groups complete a baseline questionnaire and a follow up questionaire 60 days later. The study will examine the number of Veteran Affairs (VA) mental health visits.

NCT ID: NCT01549197 Completed - Depression Clinical Trials

Quality of Dying in the Intensive Care Unit: Validation of the CAESAR Scale

CAESAR
Start date: August 2011
Phase: N/A
Study type: Observational

The purpose of the study is to evaluate the quality of the dying process in french ICUs (assessed by the CAESAR scale) and to compare physicians', nurses' and relatives perceptions and experiences, with a one-year follow-up of bereaved relatives. Our hypothesis is that perception of the quality of dying may impact on relatives' experience of bereavement (anxiety, depression, complicated grief, posttraumatic stress disorder (PTSD)).

NCT ID: NCT01548742 Completed - Clinical trials for Stress Disorders, Post-Traumatic

Meditation Interventions for Treatment of PTSD in Veterans

VMP
Start date: March 2012
Phase: N/A
Study type: Interventional

Posttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder which results in serious impairments in interpersonal, occupational and social functioning. Effective treatments are available for PTSD but they do not work for everyone. Alternative treatments are needed to help those veterans not helped by currently available treatments. Mindfulness Based Stress Reduction (MBSR) is a group based treatment focused on mindfulness meditation. MBSR has been found to be effective in helping people with problems with pain and anxiety. MBSR has not yet been studied in veterans with PTSD. The proposed study will compare MBSR with a standard psychotherapy treatment in veterans with PTSD. This research is relevant to Veterans' health because of the need to develop alternative treatments for veterans with PTSD who have not responded to currently available treatments.

NCT ID: NCT01542229 Completed - Schizophrenia Clinical Trials

PTSD (PostTraumatic Stress Disorder) Services for Veterans With SMI (Severe Mental Illness)

PTSD/SMI
Start date: May 3, 2012
Phase: N/A
Study type: Interventional

As in the general population, there is no clear standard of care within Veterans Affairs Medical Centers for treating posttraumatic stress disorder (PTSD) among individuals with severe mental illness (SMI). This is a considerable issue because trauma, posttraumatic stress disorder (PTSD), and severe psychiatric comorbidity are particularly common among Veterans and this symptom presentation clearly exacerbates the overall course and severity of mental illness. This study is significant in that it proposes to establish the efficacy of a frontline exposure based intervention for posttraumatic stress disorder (PTSD), Prolonged Exposure, for improving critical clinical, quality of life, and cost outcomes among Veterans with severe mental illness (SMI) enrolled in VA healthcare. Collectively, it is anticipated that these data will establish a much needed clinical course of action for what is considered a vulnerable yet highly underserved patient population.

NCT ID: NCT01533519 Completed - Clinical trials for Posttraumatic Stress Disorder

A Dose Escalation Study of Intranasal Neuropeptide Y in Post Traumatic Stress Disorder (PTSD)

Start date: December 2012
Phase: Phase 1
Study type: Interventional

This study is designed to investigate the safety of intranasal administration of NPY using a dose escalation, randomized, double-blinded, placebo-controlled crossover design in a medication-free, symptomatic PTSD group.