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Anxiety Disorders clinical trials

View clinical trials related to Anxiety Disorders.

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NCT ID: NCT03702803 Recruiting - Clinical trials for Generalized Anxiety Disorder

Efficacy and Safety Study of a IMSS Developed Phytopharmaceutical for the Treatment of Anxiety.

Alpra
Start date: March 16, 2016
Phase: Phase 2
Study type: Interventional

The investigator's group at the Mexican Institute of Social Security has worked for more than 20 years in the scientific research of the plant species Galphimia glauca Cav., which is used in Mexican Traditional Medicine for the treatment of mental disorders. With the obtained results it was possible the development of a phytopharmaceutical elaborated with the extract of this plant, which was standardized in its content of Galphimine-B (G-B). This new compound is a nor, seco-triterpene, which possesses selective effects on the central nervous system. Through electrophysiological neuronal unitary records it was identified that G-B acts on the ventral tegmental area (VTA), and exerts its effect on (N-methyl-D-aspartate) NMDA receptors in dopaminergic neurons. The new phytopharmaceutical, elaborated from a standardized extract (in its G-B content) of G. glauca, was subjected to a double blind and randomized clinical study that compared its efficacy and therapeutic tolerability with a similar drug formulated with lorazepam in patients with diagnosis of generalized anxiety disorder (GAD). In a total of 152 patients, it was evidenced that the phytomedicine administered orally (for 4 weeks) was able to significantly reduce anxiety, in a similar way as lorazepam did, but with better tolerability. Several patients who were treated with lorazepam had to leave the study because they had daytime sleepiness. In clinical practice, different benzodiazepines have specific indications. In the case of anxiety disorders, the drug of first choice is Alprazolam, this, because it manifests a more powerful anxiolytic effect with a lower degree of sedation and daytime sleepiness. Objective: The present project aims to compare the efficacy and therapeutic safety of an elaborated phytopharmaceutical with the standardized extract of Galphimia glauca with Alprazolam .

NCT ID: NCT03699488 Completed - Anxiety Disorders Clinical Trials

Messaging Therapy for Depression and Anxiety: 2 Longitudinal Effectiveness Studies

Start date: February 12, 2015
Phase:
Study type: Observational

Therapies delivered via technology have been developed to improve accessibility, however, there is limited research regarding messaging therapy in particular, and none that we know of utilizing a longitudinal effectiveness design. The aim of two studies was to investigate the overall effectiveness of messaging therapy, identify any contributors to its effectiveness, and to evaluate a dosage effect for this type of treatment.

NCT ID: NCT03685422 Not yet recruiting - Anxiety Clinical Trials

Preoperative Virtual Reality to Reduce Pain on Gynaecologic Patients Undergoing Surgery

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

In the perioperative setting, distraction therapies have been used as a technique to reduce anxiety and pain in the perioperative period. Measures employed in the local restructured hospitals include television, magazines, and newspapers. Tablet-based activity, music and video distraction therapy have also been shown to be useful to reduce preoperative anxiety. The investigators propose a prospective study to implement and evaluate the use of Virtual Reality (VR) in decreasing in anxiety and pain undergoing gynaecological surgery. The investigators will administer VR in 100 female adults undergoing day surgery or same-day-admission gynecologic surgery in KK Women's and Children's Hospital (KKH). The VR will be administered using a Samsung Gear VR3 headset fitted with a smartphone. VR images and sound with calming effect will be delivered to the patients for a short duration of about 10 minutes. This low-intensity activity offers soothing experience to distract the patients from any pain and anxiety.

NCT ID: NCT03684434 Not yet recruiting - Depression Clinical Trials

Online Cognitive Behaviour Therapy for Depression and Anxiety: Randomized Controlled Trial Varying Treatment Content

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Anxiety and depression are prevalent and disabling conditions. Although cognitive behaviour therapy (CBT) has been shown to significantly reduce symptoms of anxiety and depression, access to the service is limited. Internet-delivered cognitive behaviour therapy (ICBT) represents a novel approach to overcoming access barriers and involves delivering therapeutic content to manage symptoms via structured online lessons. The Online Therapy Unit has been studying the efficacy of ICBT for anxiety and depression and found that ~75% of clients complete treatment and demonstrate large improvement in symptoms. However, recent research suggests that younger clients and clients with higher baseline distress are more likely to dropout of ICBT. While it remains unclear why these clients are more susceptible to attrition, it is plausible that they are experiencing a greater degree ambivalence to change and, thus, terminate treatment as a result. Motivational interviewing (MI) aims to help facilitate clients' intrinsic motivation to change by resolving ambivalence. MI has been integrated into CBT for anxiety to overcome similar concerns of poor treatment retention. Evidence suggests that the integration of MI and CBT further enhances response and completion rates. In the context of online therapy, however, the efficacy of MI remains unclear. In the current trial, the investigators aim to assess a recently developed online MI pre-treatment (i.e., the Planning for Change lesson). A total of 300 clients applying to transdiagnostic ICBT in routine care will be randomly assigned to receive the MI pre-treatment or no pre-treatment (i.e., a waiting period) prior to participating in ICBT (i.e., the Wellbeing Course). The investigators aim to examine: how does ICBT with MI compare to standardized ICBT in terms of symptom change, rates of reliable improvement, intervention usage (e.g., number of lessons completed), frequency of motivational language in the first email to therapist, and motivation levels. It is hypothesized that there will be a small but significant effect of MI on these variables. Additionally, the investigators aim to explore if age and severity of baseline distress moderate the effect between MI and ICBT outcomes. Younger clients and clients with higher baseline distress are more likely to drop out of ICBT and, thus, it is further hypothesized that online MI will have a greater impact on these groups.

NCT ID: NCT03683823 Not yet recruiting - Clinical trials for Social Anxiety Disorder

Efficacy of an Attention Guidance VR Intervention for Social Anxiety Disorder

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

Social anxiety disorder (SAD) is a prevalent mental health concern that impacts approximately 12% of the population. One mechanism thought to maintain SAD is avoidance of faces (i.e. avoidance of negative evaluative threat). However, research on attentional processes in SAD has been confined to paradigms presented on computer monitors. To investigate attentional processes in a more naturalistic way the investigators developed an immersive, 360º-video virtual reality environment using real actors, as part of a pilot study. Participants with a range of social anxiety symptoms (from none to severe) completed a 5-minute speech in this virtual reality environment while their eye movements were recorded. Results from the study showed that greater symptoms of social anxiety were associated with avoidance of looking at faces (i.e. fewer fixations on faces). While existing treatments for SAD are moderately effective, a large number of individuals do not experience meaningful reductions in their symptoms. The overarching goal of this project is inform future treatment research for SAD. We will test a brief attention guidance intervention for SAD that specifically targets avoidance of faces as a potential mechanism maintaining the disorder. The proposed research will use the eye tracking hardware and naturalistic virtual reality environment from the pilot study. The investigators will also collect eye tracking data prior to the intervention in order to investigate potential heterogeneity in the attentional processes of SAD. The investigators will test the hypotheses that (a) the attention guidance intervention, compared to the control intervention, will result in a greater reduction in symptoms of social anxiety, and (b) this effect will be mediated by the number of fixations on faces during a brief public speaking challenge following the intervention. These results will provide causal evidence related to a hypothesized mechanism maintaining SAD.

NCT ID: NCT03683472 Not yet recruiting - Anxiety Disorders Clinical Trials

Developing a Novel Digital Therapeutic for the Treatment of Generalized Anxiety Disorder

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The investigators propose to develop and adapt Unwinding Anxiety phone app specifically for individuals with generalized anxiety disorder.

NCT ID: NCT03680755 Not yet recruiting - Dental Anxiety Clinical Trials

Efficacy of an Internet-based Intervention for Dental Anxiety

Start date: February 1, 2019
Phase: Phase 2
Study type: Interventional

The overall objective of the activities described in this protocol is to examine the efficacy of the Internet-based intervention in the reduction of dental anxiety in patients seeking dental treatment. There are a number of primary aims in service of this overall objective: 1. To determine whether the Internet-based intervention (a) is equally efficacious when administered by dental staff who have undergone a brief but specific training in the administration of the intervention as it is when administered by personnel with more extensive training and experience in CBT, a finding which would allow the greater dissemination of this intervention; and (b) to determine whether it reduces dental anxiety/fear as determined by self-ratings or assessor ratings at one month and three months post-intervention. 2. To determine whether the Internet-based intervention, administered either by CBT personnel or dental staff, is superior to an active control condition, the notification of the dental provider of the patient's score on a dental anxiety scale before the dental appointment, and 3. To determine whether the Internet-based intervention has an effect on attendance at scheduled dental appointments over the next 12 months.

NCT ID: NCT03680664 Recruiting - Anxiety Disorders Clinical Trials

Mindfulness-Based Stress Reduction (MBSR) and Transcranial Direct Current Stimulation (tDCS)

Start date: September 2018
Phase: N/A
Study type: Interventional

Ideal interventions for the older aged population would be those that are easily accessible and associated with minimal burden on family members, the healthcare system and the individuals themselves. Mindfulness-Based Stress Reduction (MBSR) therapy and Transcranial Direct Current Stimulation (tDCS) are two interventions that may be effective in targeting cognitive deficits in individuals with anxiety, depression, and/or cognitive complaints. MBSR has been shown to decrease symptoms of depression and improve cognition and tDCS has been shown to improve cognition in the older aged population. The effectiveness of these two interventions combined to elicit changes in cognition has yet to be demonstrated. Therefore, the overall aim of the current research is to evaluate the efficacy of a combination of MBSR and tDCS to improve cognitive function in individuals with cognitive complaints and symptoms of anxiety and/or depression. This will be a randomized pilot study. Sixteen individuals (separated into 2 groups of 8) will be randomized to receive a combination MBSR + active tDCS or MBSR + sham tDCS over 8 weeks. Participants will visit the Centre for Addiction and Mental Health (CAMH) once per week for in-class group sessions and will complete the intervention daily at home for the duration of the study. Participants will be aged 60 and older with cognitive complaints, with symptoms of anxiety and/or depression. Participants will be trained to self-administer tDCS and given guidelines for the completion of daily MBSR activities at home. It is hypothesized that the combination of active tDCS + MBSR will enhance cognition compared to the combination of sham tDCS + MBSR.

NCT ID: NCT03674138 Recruiting - Depression Clinical Trials

Pharmacogenomic-Guided Antidepressant Drug Prescribing in Cancer Patients

Start date: September 10, 2018
Phase: N/A
Study type: Interventional

This is a prospective, randomized clinical trial to investigate the clinical impact of a preemptive pharmacogenomics strategy to guide antidepressant therapy in cancer patients. Those enrolled onto the clinical trial will be randomized to either DNA-guided choice of therapy or clinical management alone. Scores on self-reported measures of depressive and anxiety symptoms along with quality of life will be compared between cohorts.

NCT ID: NCT03671577 Recruiting - Social Anxiety Clinical Trials

Building Closer Friendships in Social Anxiety Disorder

Start date: September 2018
Phase: N/A
Study type: Interventional

This study assesses whether a 4-week computerized intervention can be used to decrease fear of intimacy, and loneliness and improve perceived social support in people with Social Anxiety Disorder.