Social Cognition in Longstanding Psychosis

Schizophrenia Clinical Trial

Official title:

Social Cognition in Longstanding Psychosis

Clinical Trial Details — Status: Terminated

Administrative data

• NCT number: NCT01624831
• Other study ID #: U. Az IRB 11-0567-02
• Status: Terminated
• Start date: November 2011
• Est. completion date: November 2015

Study information

• Verified date: May 2020
• Source: University of Arizona
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In the current study, the investigators propose to measure the five domains of social cognition identified by the National Institute of Mental Health (NIMH) as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

Description:

There is growing evidence that individuals with longstanding psychotic disorders suffer from deficits in social cognition (i.e., the cognitive skills needed to successfully navigate social interactions). However, to date, there have been few attempts to measure multiple components of social cognition within the same population of individuals with psychosis. Thus, the interrelationships between various aspects of social cognition remain unclear. In the current study, the investigators propose to measure the five domains of social cognition identified by NIMH as relevant to individuals with psychosis (i.e., theory of mind, attribution style, emotion recognition, social perception, and social knowledge). The investigators will also explore the association between different domains of social cognition and outcomes relevant to psychotic disorder (e.g., symptomatology, social functioning, and vocational functioning).

Recruitment information / eligibility

• Status: Terminated
• Enrollment: 9
• Est. completion date: November 2015
• Est. primary completion date: November 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Diagnosis of a schizophrenia spectrum disorder or an affective disorder with psychotic features per the Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revised (DSM-IV-TR) criteria using the Structured Clinical Interview for the DSM-IV.

• Duration of psychotic symptoms greater than or equal to 5 years determined using the Symptom Onset in Schizophrenia Inventory

• Age 18-75

• No evidence of mental retardation.

• Able to provide informed consent as evidenced by passing the informed consent quiz with a score of 80% or greater.

• Fluent in English as assessed per self-report from participant

Exclusion Criteria:

• Unwilling or unable to complete study assessments (e.g., unable to read self-report questionnaires)

• Subject is currently pregnant per subject's report

Related Conditions & MeSH terms

• Bipolar Disorder
• Bipolar Disorder With Psychotic Features
• Depression
• Depressive Disorder, Major
• Disease
• Major Depression With Psychotic Features
• Mental Disorders
• Psychosis Not Otherwise Specified (NOS)
• Psychotic Disorders
• Schizoaffective Disorder
• Schizophrenia

Locations

Country	Name	City	State
United States	University of Arizona Department of Psychiatry	Tucson	Arizona

Sponsors (1)

Lead Sponsor	Collaborator
University of Arizona

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Emotion Recognition	Change from baseline to 6 month assessment in ability to recognize emotions displayed by others assessed using the Facial Emotion Identification Test	Baseline and 6 months
Primary	Attribution Style	Change from baseline to 6 month assessment in tendency to attribute events that occur to situational, personal, or internal factors assessed using the Internal, Personal, and Situational Attributions Questionnaire	Baseline and 6 months
Primary	Social Perception	Change from baseline to 6 month assessment in ability to understand concrete and abstract components of everyday social interactions assessed using the Social Cues Recognition Test	Baseline and 6 months
Primary	Social Knowledge	Change from baseline to 6 month assessment in knowledge of goals and actions associated with familiar and unfamiliar social activities assessed using the Situational Features Recognition Test	Baseline and 6 months
Primary	Theory of Mind	Change from baseline to 6 month assessment in ability to identify the mental states of other individuals assessed using the Hinting Test	Baseline and 6 months
Secondary	Anxiety	Change from baseline to 6 month assessment in anxiety assessed using the Beck Anxiety Inventory	Baseline and 6 months
Secondary	Depression	Change from baseline to 6 month assessment in depression assessed using the Beck Depression Inventory	Baseline and 6 months
Secondary	Psychosis	Change from baseline to 6 month assessment in severity of positive and negative psychotic symptoms assessed using the Positive and Negative Syndrome Scale	Baseline and 6 months
Secondary	Social Functioning	Change from baseline to 6 month assessment in level of social functioning assessed using the Social Functioning Scale	Baseline and 6 months
Secondary	Service Utilization	Change from baseline to 6 month assessment in utilization of medical services assessed using the Service Utilization Record Form	Baseline and 6 months
Secondary	Self-Determination Needs Satisfaction	Change from baseline to 6 month assessment in ability to fulfill basic needs for autonomy, competence, and relatedness assessed using the Basic Psychological Needs Scale	Baseline and 6 months
Secondary	Locus of Control	Change from baseline to 6 month assessment in perception of one's ability to control events in the environment assessed using the Multidimensional Locus of Control Scale	Baseline and 6 months
Secondary	Cognitive representation of illness	Change from baseline to 6 month assessment in understanding of nature of psychotic illness assessed using the Illness Perception Questionnaire	Baseline and 6 months
Secondary	Emotional Awareness	Change from baseline to 6 month assessment in awareness of one's own emotions as well as emotions of others assessed using the Levels of Emotional Awareness Scale	Baseline and 6 months
Secondary	Mindfulness	Change from baseline to 6 month assessment in awareness and acceptance of feelings and events assessed using the Philadelphia Mindfulness Scale	Baseline and 6 months
Secondary	Medication adherence	Change from baseline to 6 month assessment in adherence to psychiatric medication assessed using the Medication Adherence Rating Scale	Baseline and 6 months
Secondary	Neuropsychological functioning	Change from baseline to 6 month assessment in neuropsychological functioning assessed using the MATRICS Consensus Cognitive Battery	Baseline and 6 months
Secondary	Social Support	Change from baseline to 6 month assessment in level of social support assessed using the Measure of Perceived Support	Baseline and 6 months
Secondary	Illness Uncertainty	Change from baseline to 6 month assessment in uncertainty with regard to cause, course, and treatment of illness assessed using the Mischel Uncertainty in Illness Scale	Baseline and 6 months
Secondary	Relationship with familial caregivers	Change from baseline to 6 month assessment in relationship with familial caregivers assessed using the Perception of Parents Scale	Baseline and 6 months
Secondary	Self-efficacy	Change from baseline to 6 month assessment in confidence with regard to control of psychotic symptoms assessed using the Self-Efficacy Scale for Schizophrenia	Baseline and 6 months
Secondary	Experience of Stigma	Change from baseline to 6 month assessment in experience of stigma with regard to mental illness assessed using the Stigma Questionnaire	Baseline and 6 months
Secondary	quality of life	Change from baseline to 6 month assessment in quality of life assessed using the WHO Quality of Life Scale-Brief	Baseline and 6 months
Secondary	stage of recovery	Change from baseline to 6 month assessment in stage of recovery with regard to mental illness assessed using the Stages of Recovery Instrument	Baseline and 6 months
Secondary	Coping skills	Change from baseline to 6 month assessment in level of coping skills assessed using the Ways of Coping Questionnaire	Baseline and 6 months
Secondary	Time perspective	Change from baseline to 6 month assessment in time orientation assessed using the Zimbardo Time Perspective Instrument	Baseline and 6 months