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Psychotic Disorders clinical trials

View clinical trials related to Psychotic Disorders.

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NCT ID: NCT03730974 Not yet recruiting - Clinical trials for Insomnia Due to Mental Disorder

Ball Blankets on Insomnia in Depression in Outpatient Clinics

Start date: May 1, 2019
Phase: N/A
Study type: Interventional

The objective of the study is to examine the efficacy of Protac Ball BlanketsTM (PBB) and specifically if the PBB will extend the total sleep time of patients with insomnia due to depression in two psychiatric outpatient clinics at Aarhus University Hospital and Odense University Hospital. Furthermore, it will be examined whether the PBB will reduce the sleep onset latency, number of awakenings, need for sedatives and hypnotics, the self reported symptoms of depression and anxiety and improve the quality of sleep. 45 with depression and insomnia who receive outpatient treatment will be included in this study. The study is a randomized cross-over study. The data collection period lasts four weeks. Data will be collected using actigraphs, sleep diaries and questionnaires.

NCT ID: NCT03730831 Recruiting - Schizophrenia Clinical Trials

Narrative Exposure Therapy in Patients With Psychotic Disorders and a Posttraumatic Stress Disorder

NETPSYCH
Start date: January 1, 2018
Phase: N/A
Study type: Interventional

Adverse childhood experiences in psychotic disorders are associated with increased cognitive deficits, severe psychotic symptoms, and increased comorbidity. The number of different stress experiences also increases the probability of trauma-associated symptoms. Furthermore, neurobiological changes play a key role in the vulnerability of individuals with early traumas for mental and physical illnesses, among others for diseases of the schizophrenic spectrum disorder and the further course of the disease. The current project pursues a detailed recording of the course of symptoms in inpatients with psychosis to link this data with a systematic recording of childhood experiences and traumatic experiences and biological data. On a subsample of inpatients with psychosis and a comorbid post-traumatic stress disorder (PTSD), the researchers want to investigate whether symptom traits of existing psychotic disorders, biomolecular parameters and cognitive functions can be influenced by a trauma-specific treatment (NET), that has been proven to be effective in the treatment of PTSD.

NCT ID: NCT03713398 Not yet recruiting - Mental Disorder Clinical Trials

Mental Health Services for Prisoners With SMI

Start date: November 2018
Phase: N/A
Study type: Interventional

Interventions that address criminogenic risk factors, such as Thinking for a Change (T4C), are not used with prisoners with serious mental illness (SMI) because of the neurocognitive and social impairments associated with SMI. This study examines the effectiveness of T4C with a modified delivery system designed specifically to address the unique needs of persons with SMI in prison, including improving impulsivity, criminal attitudes, and interpersonal problem solving (treatment targets) and levels of aggression, and the amount of behavioral infractions and time spent in administrative segregation in prison (outcomes).

NCT ID: NCT03711500 Not yet recruiting - Schizophrenia Clinical Trials

D-serine Augmentation of Neuroplasticity

Start date: March 2019
Phase: Phase 1/Phase 2
Study type: Interventional

Schizophrenia is a major public health problem associated with cognitive deficits, such as short and long term memory, executive functioning, attention and speed of processing that are amongst the strongest predictors of impaired functional outcome. In addition, schizophrenia patients show reduced "plasticity", defined as reduced learning. D-serine is a naturally occurring activator of the N-methyl-d-aspartate-type glutamate receptors (NMDAR) in the brain, and this project will assess the optimal dose of D-serine treatment over three sessions of a program designed to measure auditory plasticity.

NCT ID: NCT03708341 Not yet recruiting - Sleep Deprivation Clinical Trials

Exogenous Melatonin in Intensive Care Unit Chronodisruption

EMIC
Start date: November 15, 2018
Phase: Phase 3
Study type: Interventional

To this day, a small number of studies have evaluated the effect of melatonin on the modifications of the characteristics of sleep in critical care units, with mostly a small studied population. However, no study has been realized on a large population, nor has it evaluated the association between genetic factors and response to treatment (melatonin), hence the originality of our study. In our study we hypothesized that systematic melatonin usage in ICU can ameliorate the total sleep time and the fragmentation index and can decrease the confusion related to sleep deprivation.

NCT ID: NCT03708315 Not yet recruiting - Schizophrenia Clinical Trials

Precedex for Schizophrenia

DEX
Start date: November 2019
Phase: Phase 2
Study type: Interventional

Agitation is characterized by excessive motor or verbal activity, irritability, uncooperativeness, threatening gestures, and, in some cases, aggressive or violent behavior. While agitation may have various underlying causes, patients with schizophrenia are especially vulnerable to acute episodes of agitation, especially during exacerbation of disease, and clinicians do not always diagnose these episodes early enough. Agitation associated with psychosis is a frequent reason for emergency department visits, and unless it is recognized early and managed effectively, it can rapidly escalate to potentially dangerous behaviors, including physical violence. Educating psychiatric professionals about the timely and accurate diagnosis of agitation among patients with schizophrenia or bipolar disorder and developing a well-tolerated easily administered medication will contribute to the prompt and effective management of this condition and could help reduce the risk of violent behavior and other undesirable outcomes. This study is designed to identify the ideal dose range and tolerability of I.V Dexmedetomidine as a prelude to testing a sublingual formulation for efficacy in patients with schizophrenia.

NCT ID: NCT03705143 Active, not recruiting - Clinical trials for Substance-Related Disorders

Behavioral Activation for Heroin Use in China: A Randomized Controlled Trial

Start date: June 4, 2018
Phase: N/A
Study type: Interventional

This was a single-site two-arm parallel-group trial conducted in a Methadone Maintenance Treatment (MMT) Clinic that provides medication service for 254 heroin users in Wuhan, China. Once consented and completed the pre-treatment assessment, participants were randomized to receive either the Chinese translated behavioral activation treatment for substance use (C-BA) or treatment as usual (TAU). Research assessments occurred at pre-treatment, post-treatment, and 1- and 3-months follow-ups. The primary purpose of this study is to: 1. Evaluate the feasibility, acceptability, and efficacy of the Chinese-translated behavioral activation treatment for substance use (C-BA), an evidence based intervention developed to address the individual and psychological needs of Chinese substance users. The secondary purpose of this study is to: Examine the underlying mechanism of C-BA by studying the relationship between change in substance use related outcomes and associated psychological constructs (e.g. levels of behavioral activation and depression).

NCT ID: NCT03704805 Recruiting - HIV Infections Clinical Trials

Effect of a Psychological Intervention on Antiretroviral Therapy and Mental Health Outcomes in HIV-positive Adults in Zimbabwe

Start date: October 5, 2018
Phase: N/A
Study type: Interventional

The aim of the study is to examine the effect of a psychological intervention on antiretroviral therapy outcomes and symptoms of common mental health disorders among adults living with HIV and common mental disorders in rural Zimbabwe.

NCT ID: NCT03701100 Completed - Schizophrenia Clinical Trials

The Effects of Bimodal tDCS on Illness Severity, Insight, Functional Outcomes, Neurocognition and HRV in Schizophrenia

Start date: July 17, 2017
Phase: N/A
Study type: Interventional

The study aimed to investigate the effects of bimodal anodal transcranial direct current stimulation (tDCS) over bilateral dorsolateral prefrontal cortex (DLPFC) on psychopathological symptoms, insight, psychosocial functioning, neurocognitive function and heart rate variability (HRV) in schizophrenia patients

NCT ID: NCT03700008 Recruiting - Mental Disorder Clinical Trials

Content-free Speech Analysis for Measurement of Mental Health

Start date: October 15, 2018
Phase: N/A
Study type: Interventional

Trial to prove the functionality and efficacy of a content-free speech analysis tool to detect problematic mental health status or phases of patients with pre known or unknown mental health disorders, focussed on affective disorders or neurodevelopmental disorders. The participants talk in free speech to the tool, this will be analyzed content-free and compared with psychological instruments to detect the mental status in conventional way.