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Psychotic Disorders clinical trials

View clinical trials related to Psychotic Disorders.

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NCT ID: NCT03807427 Completed - Mental Disorders Clinical Trials

Regulating Emotions Through Adapted Dialectical Behavior Skills for Youth (READY-Nepal)

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

Published research on the development of mental health symptomatology among adolescents has expanded in recent years and indicates the presence of a growing public health concern. The 2015 earthquakes in Nepal are a risk factor for increased psychological distress across all age groups. Prior studies have also demonstrated high chronic risk of suicidal thoughts and behaviors (STBs) among adolescents in Nepal and throughout South Asia. Despite the need for mental health promotion interventions in Nepal, there is a lack of psychological treatments for suicide prevention that have been rigorously evaluated in Nepal. To address this gap, a trans diagnostic, emotion -focused mental health promotion intervention (Regulating Emotions through Adapted Dialectical behavior skills for Youth in NepalÍž READY-Nepal) was developed for delivery in school-based settings. A pilot quasi-experimental trial utilizing a wait-list control group will be used to evaluate the feasibility and acceptability of the intervention in a cohort of school -going adolescents in the Kathmandu Valley. Qualitative methodology will be used to augment quantitative findings via exploration of gender differences in perception and uptake of the program, program feasibility and acceptability, as well as changes in coping skills and explanatory models of stress between baseline and follow- up. This pilot study will aid in modifying the intervention to inform the development of a larger, adequately powered cluster randomized trial (CRT) of READY-Nepal.

NCT ID: NCT03807388 Not yet recruiting - Schizophrenia Clinical Trials

ReMindCare App for Patients From First Episode of Psychosis Unit.

Start date: September 2019
Phase: N/A
Study type: Interventional

ReMindCare is an app designed by the Unit of Psychiatry at the Clinical Hospital of Valencia in liaison with the Polytechnic University of Valencia. This e-Health app gathers information about the clinical health status of patients with Psychotic Disorder Diagnose through daily and weekly brief assessments. This information is displayed in a restricted access website, where clinicians can visualize data from patients as well as download pdf reports of main data collected by the app. These reports can be attached to the electronic clinical report of the patient at the hospital database, being accessible for consultation for every clinician involved in treatment of the patient. Furthermore, ReMindCare produces different alarms which notify clinicians about variations into patients health status or the cessation of using the app. Moreover, patients can also deliberately generate an urgent consultation alarm. The introduction of ReMindCare app into clinical practice will follow a clinical trial structure in which treatment as usual (TAU) of patients from a First Episode of Psychosis Unit will be compared to ReMindCare app intervention program. After participants eligible for inclusion complete baseline assessments they will be randomly allocated to one of the two groups (Intervention or TAU) by a basic single blind randomization in which an independent researcher will perform the allocation using a computerized random number generator. Information collected through the app and variations into clinical data will be analyzed among time. First assessment of these data will be conducted after 6 months of patient´s enrollment into the study. Subsequent analysis will be conducted yearly.

NCT ID: NCT03800368 Completed - Psychotic Disorders Clinical Trials

Exercise and Overnight Motor Sequence Task

Start date: December 21, 2016
Phase: N/A
Study type: Interventional

The objective of this randomized controlled trial (RCT) is to compare the changes of the sleep-related memory functions in patients with psychosis after they have completed the 12-week high-intensity exercise intervention, the 12-week low-intensity exercise intervention, or the 12-week controlled non-exercise intervention respectively. Fifty-one patients with psychosis, patients who received either the high-intensity exercise or low-intensity exercise as intervention shown a significant improvement to their impaired sleep-related memory function, while those who received non-exercise intervention has no such improvement. Moreover, high-intensity exercise may have a more prominent effect compare to low-intensity exercise.

NCT ID: NCT03794076 Not yet recruiting - Schizophrenia Clinical Trials

Cromoglycate Adjunctive Therapy for Outpatients With Schizophrenia

Start date: January 2019
Phase: Phase 1/Phase 2
Study type: Interventional

This is a double blind adjunctive randomized controlled trial for schizophrenia using cromoglicate.

NCT ID: NCT03788993 Recruiting - Mental Disorder Clinical Trials

Testing the Effectiveness of an Evening Blue-depleted Light Environment in an Acute Psychiatric Ward

Start date: October 23, 2018
Phase: N/A
Study type: Interventional

There is increasing recognition of the need to stabilize sleep-wake cycles in individuals with major mental disorders. As such, clinicians and researchers advocate for the use of interventions targeted at sleep and circadian dysrhythmias as an adjunct to the standard treatments offered for acute illness episodes of a broad range of diagnoses. To determine the trans-diagnostic generalizability of chronotherapy, the investigators will explore the benefits of admitting individuals with major mental disorders to an acute psychiatric inpatient unit where changes in light exposure are integrated into the therapeutic environment. A two-arm pragmatic effectiveness randomized controlled treatment trial, where individuals admitted for inpatient psychiatric care will be allocated to a ward with blue depleted evening light or to a ward with the same layout and facilities but lacking the new lighting technology. The trial will test whether the experimental lighting conditions offer any additional benefits beyond those associated with usual treatment in an acute psychiatric inpatient unit. The main objectives are to examine any differences between groups in the mean duration of hospitalization in days. Additional analyses will compare groups differences in sleep, functioning, symptoms, medication usage, and side-effects and whether length of stay is associated with stability of sleep-wake cycles and circadian rhythms. Given this unique research opportunity, ancillary investigations will determine any benefits according to diagnostic subgroups and potential drawbacks such as any adverse effects on the well-being of professionals working across both wards.

NCT ID: NCT03786328 Completed - Depression, Anxiety Clinical Trials

An Outreach Collaborative Model for Early Identification and Treatment of Mental Disorder in Danish Workplaces

Start date: April 1, 2008
Phase: N/A
Study type: Interventional

Depression and anxiety are prevalent mental disorders among the working population with potentially high personal and financial cost. The aim of the study is to test the applicability of an outreach collaborative model for early identification and treatment of clinical and sub-clinical mental disorders among Danish employees. applicability was examined by I) investigating the fractions of identified and treated clinical and subclinical cases, II) describing the distribution and characteristics of cases identified and III) investigating the effect of allocated treatment. A longitudinal study design with four assessments over 16 months are applied. Six medium-large companies will be included, both public and private cooperations. Self-reporting questionnaires probing for psychopathology will be distributed to all employees in the six consecutively enrolled companies at the four time points. Employees meeting the screening criteria at T1 will be assessed diagnostically. Subjects diagnosed with a clinical mental disorder will be allocated to outpatient psychiatric treatment, and subjects with subclinical conditions will be allocated to preventive cognitive behavioural therapy. Follow-up is conducted 6 and 12 months after initiation of treatment. Participation in the study is voluntary at all levels. Written informed consent will be obtained from participant selected for diagnostic interview and treatment.

NCT ID: NCT03785912 Not yet recruiting - Mental Disorder Clinical Trials

SelFIT: Internet-based Treatment for Adjustment Problems After an Accident

Start date: September 2019
Phase: N/A
Study type: Interventional

In this study, people who suffer from adjustment problems after having experienced an accident will be randomized to one of two study groups. The first group receives access to the unguided internet-based self-help intervention immediately. The second group is a waiting control group that receives access to the program 12 weeks later. In both conditions additional care or treatment is allowed. The aim of the study is to investigate the efficacy and cost-effectiveness of an internet-based unguided self-help intervention for people with adjustment problems after an accident compared to a waiting list. There are 6 assessments: baseline, two between-measurements (after 4 and 8 weeks), post assessment (after 12 weeks) and two follow-up assessments (after 3 and 6 months). All participants from both groups are asked to fill out all assessments.

NCT ID: NCT03774641 Recruiting - Clinical trials for Major Depressive Disorder

A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women

Start date: December 3, 2018
Study type: Observational

Pregnant women who are taking lamotrigine will be evaluated monthly during pregnancy including a clinical evaluation and a blood draw for lamotrigine levels at each visit. Based on the Therapeutic Drug Monitoring protocol, participant's lamotrigine dosing will be adjusted as needed based on participant's blood levels compared to the reference concentration that was obtained prior to pregnancy or early in pregnancy while clinically stable. After delivery participant and participant's infants will be assessed for mood and functioning at 1, 2, 4, and 6 weeks postpartum.

NCT ID: NCT03769493 Recruiting - Psychotic Disorders Clinical Trials

Mobile After-Care Intervention to Support Post-Hospital Transition (MACS)

Start date: December 2018
Phase: N/A
Study type: Interventional

This study examines the feasibility and acceptability of a mobile device-delivered app, called Mobile After-Care Support (MACS), to improve patients' coping and treatment adherence following a hospitalization related to their psychotic-spectrum disorder.

NCT ID: NCT03767101 Enrolling by invitation - Mental Disorders Clinical Trials

Positive Affect and Mental Imagery in the Process of Cognitive Behavioural Therapy

Start date: November 2, 2018
Phase: N/A
Study type: Interventional

Background: Several evidences suggest that persons with mental disorders show a dysfunctional upregulation of negative affect but at the same time a dysfunctional downregulation of positive affect. Nevertheless positive affect in patients or treatment processes is barely researched. Experimental paradigms with healthy and subclinical populations show that induced positive affects leads to higher flexibility in information processing, cognitive appraisal and action tendencies. Furthermore higher amounts of positive affect are associated with more personal resources, higher psychological resilience and subjective well-being. A small body of research indicate that focusing on positive and functional aspects in the life of patients could be useful for treatment outcome. However, the role of positive affect for the process in cognitive behavioral therapy remains unclear. Method/Design: In regard to this we developed the PACIfIC-study, serving two major objectives: - To develope and test the feasibility of a brief, audio-tape presented mental imagery intervention, that is used at the beginning of individual treatment sessions to induce positive affect. - To review the effects of this positive intervention on the therapeutic process between and within sessions in comparison to another active mental imagery condition and a control condition. The study includes a randomized, longitudinal design in a outpatient treatment center. The interventions are conducted in the first eight therapeutic sessions of each treatment and are used in a patient sample with various mental disorders. Outcomes were raised by self-rating questionnaires and video-analysis of treatment sessions in both patients and therapists. A continuation of the respective mental imagery intervention in the course of treatment and its evaluation is considered if patients give their content. Discussion: The study results could have important theoretical and practical implications on the use of positive affect in psychotherapeutic treatment. Furthermore an economic implementation of brief positive interventions in general practice could be initiated.