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Clinical Trial Summary

In this study, an APA program by web (e-APA) will be offered to two groups of participants (21 patients and 21 healthy volunteers (HV)) in remote video (use of the SAPATIC (Santé Activités Physiques Adaptées utilisant les Technologies de l'Information et de la Communication) platform developed by the company V@SI). At the same time, two control groups, a group of 21 patients and a group of 21 HV will undergo an health education program (HE) through the collaborative SAPATIC health platform of V@Si and will constitute the control groups. The content of the APA sessions will be administered by V@Si. This program offers content aimed to improve aerobic capacity and muscular strength while relying on the motivation of the participants

Clinical Trial Description

The main objective is to demonstrate that APA can improve cerebral plasticity in patients with schizophrenic or schizoaffective disorders (SCZ), reflected by an increase in the overall volume of hippocampus.

The secondary objectives will also be to assess the impact of APA on the SCZ compared to the HV:

1. on other cerebral variables (changes in the different subregions of the hippocampus (Cornu Ammonis (CA: CA1,CA2-3-4), subiculum and dentate gyrus), cortical thickness, N-acetyl aspartate (NAA) and glutamate as well as changes in the white matter through the diffusion markers (fractional anisotropy, radial diffusivity and mean diffusivity in the frontomedial-hippocampal fibers) and cerebral irrigation

2. on physiological variables (neuromuscular, cardiovascular (heart rate variability) and aerobic)

3. on cognitive variables by measuring working memory, episodic memory, attentional and executive functions

4. on circadian rhythms (temperature, actimetry and wake-sleep cycle)

5. on the clinical status of patients (severity of symptoms, quality of life, level of activity and physical abilities).

6. on biological variables (fasting glucose, triglycerides, total cholesterol, High-density lipoprotein cholesterol (HDLc), Low-density lipoprotein cholesterol (LDLc) ;

Study Design

Related Conditions & MeSH terms

NCT number NCT03261817
Study type Interventional
Source University Hospital, Caen
Contact Sonia Dollfus, Prof
Phone +33231065018
Status Recruiting
Phase N/A
Start date September 29, 2017
Completion date December 31, 2022

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