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Depressive Disorder, Major clinical trials

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NCT ID: NCT03468686 Recruiting - Clinical trials for Major Depressive Disorder

The Comparison of Effectiveness of CBT and rTMS on Anhedonia and Rumination in Patients With MDD

Start date: December 21, 2016
Phase: N/A
Study type: Interventional

This study aims to compare the effectiveness of rTMS, classical cognitive-behavioral therapy and religious cognitive-behavioral therapy on the reduction of Anhedonia and rumination and their associated neural networks. In a randomized double-blind trial, 60 patients with major depressive disorder (MDD) in Atieh Clinical Neuroscience Center are assigned to four groups. The first group receives bilateral rTMS for 10 sessions on DLPFC; the second group receives sham rTMS for 10 sessions. In this group, the stimulation parameters are similar to that in the actual rTMS group, except that the coil angel is 90° and perpendicular to the head. In the third group, patients receive classical cognitive-behavioral therapy for 10 sessions. In the fourth group, patients receive religious cognitive-behavioral therapy for 10 sessions. Anhedonia symptoms will be measured by the Snaith-Hamilton Pleasure Scale (SHAPS), and rumination symptoms will be measured by the Ruminative Responses Scale (RRS) in the baseline and in the end of 10th session. In order to investigate neural networks associated with Anhedonia and rumination, EEG of patients will be recorded at the first session and at the end of the treatment.

NCT ID: NCT03460574 Recruiting - Clinical trials for Major Depressive Disorder

Targeting Cognitive Immunization in Depression

Start date: October 14, 2017
Phase: N/A
Study type: Interventional

Research has shown that people suffering from MDD tend to maintain dysfunctional expectations despite experiences that disconfirm expectations. Recently, it has been shown that this persistence of expectations is due to maladaptive information processing involving "cognitive immunization". This experimental study aims at testing three different strategies to inhibit cognitive immunization, in order to enhance expectation change.

NCT ID: NCT03452384 Completed - Clinical trials for Major Depressive Disorder

Acupuncture in Depression: From the Clinical Trial, Biomarkers to Molecular Biology

Start date: November 6, 2014
Phase: N/A
Study type: Interventional

Major depressive disorder (MDD) is a serious psychiatric illness with a high lifetime prevalence rate and causes major clinical, social and economic burden to patients and their family. Despite more than 40 antidepressants with various mechanisms are available on the market, half of patients fail to achieve remission with optimized medication treatment. Due to unsatisfactory efficacy, frequent intolerability and poor compliance of psychopharmacotherapies, novel and safe alternative therapies are critically in need to improve the treatment of depression. Traditional Chinese medicine (TCM) theory describes a state of health maintained by a balance of energy in the body. If imbalanced, it can be corrected by acupuncture, the insertion of fine needles into different parts of the body. Although there are several clinical trials to demonstrate the antidepressant effects of acupuncture, its biological and physiological mechanisms are still unknown. In addition, clinical depression is frequently accompanied with somatic presentations, which are related to autonomic nervous dysfunction. It would be of interest to know if acupuncture could regulate autonomic nervous system (ANS) and improve the somatic symptoms in depression. The purpose of this study is to assess the effectiveness of acupuncture in the treatment of depression and to determine the influence of acupuncture on the molecular and ANS systems.

NCT ID: NCT03449979 Recruiting - Depression Clinical Trials

Single Session of tACS in a Depressive Episode

Start date: March 2018
Phase: N/A
Study type: Interventional

Purpose: Investigating the effects of non-invasive transcranial alternating current stimulation (tACS) on healthy participants and participants with mood disorders. Participants: 30 males and females, ages 18-65, with depressed mood; 30 healthy males and females, ages 18-65, free of neurological or psychiatric conditions. Procedures: This is a single visit study with two stimulation conditions (tACS and sham tACS). The session will begin with clinical assessments (behavioral inhibition and behavioral activation scales (BIS/BAS), the structured clinical interview for the DSM-5 (SCID), and the hamilton-depression rating scale 17 item (HDRS17)), followed by a 7 minute resting state EEG (2 minutes eyes closed, 5 minutes eyes open), followed by the stimulation session (40 minutes of tACS or sham tACS), followed by an additional 5 minute resting state EEG. An additional 10 minutes of EEG will be collected following this 5 minute resting state (2 minutes segments, with 30 second breaks). The stimulation will involved 40 minutes of transcranial alternating current stimulation, 2mA in amplitude and 10 Hz frequency.

NCT ID: NCT03449394 Recruiting - Depression Clinical Trials

Effect of 4-session Metacognitive Training in Chinese Adult Outpatients With Schizophrenia Spectrum Disorders and Major Depressive Disorder

Start date: April 2015
Phase: N/A
Study type: Interventional

Psychological studies have shown that individuals tend to attribute causes of positive and negative events differently. Specifically, individuals hold an internalising or externalising bias of attribution which, in the case of particular patient groups, was found to polarize to the extreme. Such extreme attributional styles have found to have a direct impact on emotions, leading to a waning course of psychiatric disorders. This project aims to further examine the theoretical links between attributions and emotions using a transdiagnostic approach, and the effect of a 4-session process-based intervention on attributional biases.

NCT ID: NCT03446846 Not yet recruiting - Clinical trials for Major Depressive Disorder

A Study to Evaluate the Efficacy and Safety of MIN-117 in Adult Patients With Major Depressive Disorder

Start date: March 31, 2018
Phase: Phase 2
Study type: Interventional

MIN-117C03 is a 6-week, 3-arm, randomized, double-blind, placebo-controlled study to investigate the safety and efficacy of MIN-117 in male and female patients with Major Depressive Disorder, aged 18 to 65 years. Approximately 324 patients will be randomly assigned to 1 of 3 treatment arms, including placebo, 5.0 mg MIN-117, or 2.5 mg MIN-117 in a 2:1:1 ratio.

NCT ID: NCT03437928 Not yet recruiting - Clinical trials for Major Depressive Disorder

Deep Brain Stimulation (DBS) for Depression Using Directional Current Steering and Individualized Network Targeting

Start date: May 1, 2018
Phase: N/A
Study type: Interventional

The goal of the study is to address the unmet need of TRD patients by identifying brain networks critical for treating depression and to use next generation precision DBS with steering capability to engage these targeted networks. The study's goal will be achieved through 3 specific aims: 1. Demonstrate device capability to selectively and predictably engage distinct brain networks 2. Delineate depression-relevant networks and demonstrate behavioral changes with network-targeted stimulation 3. Demonstrate that chronic DBS using steered, individualized targeting is feasible and safe for reducing depressive symptoms

NCT ID: NCT03436823 Not yet recruiting - Clinical trials for Depressive Disorder, Major

Does Nurse Semi Structured Interview Added to a rTMS Improve Patients With Major Depressive Disorder?

Start date: February 28, 2018
Phase: N/A
Study type: Interventional

Repeated Transcranial Magnetic Stimulation - R.TMS - is currently part of the treatment for depressive illness. This non-invasive technique is designed to stimulate certain areas of the cerebral cortex involved in this pathology. FDA approved this treatment in routine for depressive illness. R.TMS still remains in assessment. Due to the heterogeneity of methods and the weakness of the cohorts therapeutic superiority can not concluded . Stimulation parameters remain numerous even if a consensus is beginning to emerge. The therapeutic target is the left dorso - lateral prefrontal cortex. The lack of efficacy is probably due of the inaccuracy. The empirically location of the target does not take into account the inter-individual anatomical differences. The neuronavigation is becoming widespread in routine clinical practice. The referent nurse stays with the patient all along the rTMS sessions. His role is to set up treatment, to ensure the safety and the well-being of the patient. An rTMS session is an average of 30 minutes and is a very special moment to create a specific therapeutic relationship. No study was conducted to evaluate the therapeutic relationship. The assumption is made that rTMS with a semi - structured interview provides a qualitative and quantitative clinical response greater than a semi - structured rTMS without this nursing care. The investigators therefore propose to patients not receiving a semi-structured interview to listen to music with eyes closed.

NCT ID: NCT03435744 Not yet recruiting - Clinical trials for Major Depressive Disorder

Simvastatin as an Augmentation Treatment for Treatment Resistant Depression: Randomized Controlled Trial.

Start date: April 1, 2018
Phase: Phase 3
Study type: Interventional

In this double blind, randomized placebo controlled trial we aim to determine the efficacy of simvastatin as an add-on treatment for treatment resistant depression. We will recruit 150 people with treatment-resistant depression with the aim of determining whether the addition of simvastatin (20mg daily) to treatment as usual (TAU) for 12 weeks leads to an improvement in depressive symptom compared with placebo added to TAU.

NCT ID: NCT03433339 Not yet recruiting - Clinical trials for Major Depressive Disorder

Spinal Cord Stimulation for the Treatment of Major Depressive Disorder

Start date: March 2018
Phase: Phase 1/Phase 2
Study type: Interventional

This pilot clinical trial will evaluate the efficacy and safety of transcutaneous direct current stimulation (tsDCS) in major depressive disorder.