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Pain clinical trials

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NCT ID: NCT03170557 Not yet recruiting - Pain Clinical Trials

Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation

Start date: June 2017
Phase: N/A
Study type: Interventional

Pain is one of the most common problems in patients with spinal cord injury (SCI) and persistent pain (that can be of different origin: nociceptive, neuropathic or mixed) is often poorly responsive to pharmacological therapy. Attention has been paid to the use of non-pharmacological therapies and interventional techniques in treating pain in other clinical conditions, and acupuncture has been the treatment most used and appreciated for its effectiveness. However, only few studies are available on the use of acupuncture in SCI patients. The present randomized, comparative trial aims to clarify the efficacy of traditional acupuncture vs. aspecific needle skin stimulation in treating persistent pain in subjects with spinal cord injury, by overcoming the biases reported in previous studies.

NCT ID: NCT03169127 Recruiting - Pain Clinical Trials

Clinical Pharmacogenetic of Ibuprofen After Lower Third Molar Surgeries

Start date: April 1, 2016
Phase: Phase 4
Study type: Interventional

The present clinical trial randomized will be to assess the link between the different haplotypes of CYP2C8 and CYP2C9 genes and the clinical efficacy of ibuprofen after lower third molar extractions. Onset, duration of postoperative analgesia, duration of anesthetic action on soft tissues, intraoperative bleeding, hemodynamic parameters, postoperative mouth opening and wound healing at the 7th postoperative day were evaluated. For this purpose, 200 healthy volunteers underwent removal of one lower third molar, under local anesthesia with articaine 4% (1:200,000 adrenaline) will be genotyped and phenotyped for these genes and their postoperative records with all data collected will be compared with the haplotypes found in the Brazilian population.

NCT ID: NCT03164343 Not yet recruiting - Pain Clinical Trials

Pain Neuroscience Education in Healthy Children

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

The primary objective of this study is to examine whether Pain Neuroscience Education for children is able to increase a child's knowledge on the neurophysiology of pain. In addition, this study investigates the influence of PNE on several pain related outcomes; pain-related fear, pain catastrophizing and pain vigilance and awareness.

NCT ID: NCT03162835 Not yet recruiting - Pain Clinical Trials

Development and Clinimetric Properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire in Healthy Children

Start date: June 1, 2017
Phase: N/A
Study type: Observational

The scientific objective of this research implies developing and examining the clinimetric properties of the Dutch Pediatric Neurophysiology of Pain Questionnaire (PedNPQ) in healthy children. A total study sample of 60 healthy children (30 from 2nd and 3rd primary school) will be included to measure test-retest reliability of the Pediatric Neurophysiology of Pain Questionnaire (PedNPQ). Children will be asked to fill in the questionnaire twice, with a time interval of 48 hours (assessment T0 and T1). In order to assess concurrent validity of the PedNPQ, 30 children (15 from 2nd and 3rd primary school) as well as their parent will receive a pediatric Pain Neuroscience Education (PNE) session. It is hypothesized that if the developed PedNPQ is valid, children who received PNE will perform better than children receiving no PNE. To reduce the participant's workload, all assessments will be done immediately after the school hours or during recreation, in the primary school of the participant.

NCT ID: NCT03157882 Recruiting - Pain Clinical Trials

Pediatric Pain Assessment in the Emergency Department

Start date: October 2016
Phase: N/A
Study type: Observational

To examine pediatric pain assessment in the Emergency Department

NCT ID: NCT03155516 Recruiting - Pain Clinical Trials

Effect of Good Pain Management (GPM) Ward Program on Moderate to Severe Cancer Pain Patients

GPM
Start date: August 30, 2016
Phase: N/A
Study type: Interventional

This study aims to set up a standardized cancer pain ward - known as the Good Pain Management (GPM) Ward with streamlined assessment and management procedures to act as a pain management model. In particular, it will enforce regular pain assessment from and throughout hospital admission, and treatment protocols introducing the use of strong-opioids in moderate cancer pain patients, following National Cancer Care Network (NCCN) Adult Cancer Pain Guidelines. The GPM ward will be compared against current-practice controlled ward.

NCT ID: NCT03153813 Recruiting - Pain Clinical Trials

Capsaicin Patches In Knee Osteoarthritis In Obese Patients

CHILI-OB
Start date: July 2015
Phase: Phase 3
Study type: Interventional

To assess the efficacy and safety of high concentration capsaicin patches in pain due to osteoarthritis (OA) of the knee in patients with obesity

NCT ID: NCT03152578 Not yet recruiting - Pain Clinical Trials

Topical Use of 20% Beta Caryophyllene Alone And In Combination With 0.025% Capsaicin for Pain Caused by Osteoarthritis Of The Knee

Start date: June 1, 2017
Phase: Phase 2
Study type: Interventional

This study consists of a randomized, double-blind, placebo-controlled crossover trial with open label extension evaluating a topical natural health cream containing ß-caryophyllene alone and in combination with 0.025% capsicum oleoresin against placebo. At the end of the randomized controlled phase of the trial all participants will be given open-label combination cream to be administered over the subsequent 3 weeks. Primary Endpoint: Evaluation of improvement in pain interference as measured by the BPI in individuals who are experiencing pain due to osteoarthritis of the knee. Secondary Endpoints: Secondary endpoints are: Confirmation of safety of the topical cream when used daily over 10 weeks. Further evaluation will include overall patient satisfaction with the products tested.

NCT ID: NCT03150433 Not yet recruiting - Pain Clinical Trials

Sleep and Pain in Sickle Cell Disease

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

This is a study testing the effects of behavioral sleep interventions on pain and brain function in sickle cell disease.

NCT ID: NCT03146806 Not yet recruiting - Pain Clinical Trials

Intranasal (NAS) Ketamine for Cancer Pain

Start date: July 1, 2017
Phase: Phase 1/Phase 2
Study type: Interventional

The main purpose of this study is to determine the safety, feasibility, and utility of intranasal (NAS) ketamine in persistent uncontrolled cancer related pain. In this prospective clinical trial the researchers will investigate the use of NAS ketamine in patients with pain related to cancer or cancer treatment. The researchers plan to enroll at least 15 patients meeting inclusion/exclusion criteria, to achieve a minimum of 10 patients who complete the study. Participants will be recruited from the supportive oncology clinic, oncology clinics, the pain clinic and Acute Pain Service at Emory. Participants will be asked to return to the Phase I unit of the Winship Cancer Building C for a total of 5 study visits, each two to five days apart. During these visits participants will complete questionnaires, have blood samples drawn and will have study medication administered to them in escalating doses. For safety monitoring participants will be contacted by telephone 14 days after the last dose of medication administered.