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Pain clinical trials

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NCT ID: NCT05283980 Active, not recruiting - Pain Clinical Trials

Pectoral Nerve Blocks (PECs) for Cardiovascular Implantable Electronic Device Placement

Start date: November 17, 2022
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this study is to determine whether administration of a pectoral nerve blocks (Pecs I and II) with 0.25% bupivacaine are more effective as compared to placebo to provide analgesia for cardiac implantable electronic device (CIED) placement in cardiac electrophysiology lab

NCT ID: NCT05282706 Enrolling by invitation - Nausea Clinical Trials

Use of Aromatherapy in Conjunction With Physical/Occupational Therapy in an Acute Care Setting

Start date: May 16, 2022
Phase: Phase 1
Study type: Interventional

Use of inhaled essential oils to reduce the symptoms of pain or nausea, enabling a patient to have increase participation with PT or OT, thereby minimizing hospitalization-related risks and potentially reducing the length of stay in the hospital.

NCT ID: NCT05280847 Completed - Pain Clinical Trials

Analysis of Injectate Spread During Erector Spinae Block

Start date: February 21, 2022
Phase: N/A
Study type: Interventional

The primary purpose of this study was to identify the ESPB spread level in the craniocaudal direction when performed at the T2 level. The secondary purpose was to determine the incidence of spread into epidural, paravertebral, intercostal, and intravascular injections with ESPB

NCT ID: NCT05279898 Recruiting - Pain Clinical Trials

Perioperative Multimodal General AnesTHesia Focusing on Specific CNS Targets in Patients Undergoing carDiac surgERies

PATHFINDERII
Start date: February 28, 2023
Phase: N/A
Study type: Interventional

In the PATHFINDER 2 trial, the study investigators will test the intraoperative EEG-guided multimodal general anesthesia (MMGA) management strategy in combination with a postoperative protocolized analgesic approach to: 1. reduce the incidence of perioperative neurocognitive dysfunction in cardiac surgical patients 2. ensure hemodynamic stability and decrease use of vasopressors in the operating rooms 3. reduce pain and opioid consumption postoperatively

NCT ID: NCT05276258 Enrolling by invitation - Pain Clinical Trials

Cryoablation of Intercostal Nerves for Post-Operative Pain Management in Opioid-Tolerant Patients

Start date: February 1, 2023
Phase: N/A
Study type: Interventional

The main objective study is to compare the use of the cryoSPHERE probe to the standard-of-care method for pain management of patients receiving robotic-assisted thoracoscopic surgery, including reductions in opioid pain medication use and the development of post-surgical morbidity.

NCT ID: NCT05275881 Recruiting - Pain Clinical Trials

Impact of Virtual Reality in Pediatric Hematology and Oncology

Start date: October 13, 2022
Phase: N/A
Study type: Interventional

This pilot study will be testing the feasibility of medical hypnosis through virtual reality during invasive médical procédures in children with cancer. Patients age from 7 to under 18 years whose treatement protocols required a lumbure puncture and a chemotherapy by implantable venous access will be randomly assigned to virtual reality or treatement as usual (nitrous oxide, anxiolytics, opioid analgesics, psychotropic and benzodiazepine). We expect the same benefit by using VR as usual intervention.

NCT ID: NCT05275751 Completed - Pain Clinical Trials

Mechanisms of Human Heat Perception - Involvement of TRPA1, TRPV1 and TRPM3

Start date: June 13, 2022
Phase: Early Phase 1
Study type: Interventional

Animal studies suggest that the ion channels TRPV1, TRPA1 and TRPM3 are the relevant heat sensors. This study aims to validate these findings in humans.

NCT ID: NCT05272488 Recruiting - Pain Clinical Trials

A Combined Treatment of Manual Therapy and Nervous Vagus Stimulation in Patients With Myogenic Temporomandibular Disorders

Start date: August 1, 2022
Phase: N/A
Study type: Interventional

Temporomandibular disorders (TMD) are one of the most important Public Health issues in the world and its incidence has increased over the years. The Physiotherapy and manual therapy techniques has shown its efficacy to reduce pain and to improve jaw functionality in patients with TMD. Until now, treatment targets has been the muscle and joint, but clinicians has not taken into account the innervation and how the nerve can have an influence in pain or jaw functionality. In this sense, it is known that there is a relationship between jaw innervation and vagus nerve, a parasympathetic nerve which is easily stimulable, due to its connection with the respiratory system, taking deep breaths using the diaphragm. Therefore, our hypothesis is that a treatment in which clinicians combine manual therapy and nerve vagus stimulation could have better effects (reducing pain, increasing range of motion in temporomandibular joints and improving quality of life in patients with TMD) than a isolated manual therapy treatment. With this purpose will be selected 20 subjects to participate in our study divided in two groups. Both groups will received 4 sessions of physiotherapy (one each 7 days during one month) and also will be thought to do own treatment those days the subjects does not come to the clinic until the study will have finished (the interventional period last two months). Both groups will received the same manual therapy techniques but only the experimental group will be treated with nerve vagus stimulation technique. One member of the group who will not participated in the interventions will be in charge of do evaluations (1 each month/ a total of 3 evaluations) following different questionaries to assess the primary variables of the study: chronic pain level, jaw functionality, physical symptoms level, range of motion and distress level.

NCT ID: NCT05270447 Completed - Pain Clinical Trials

Short-Term Effects of Connective Tissue Massage After Hysterectomy

Start date: October 12, 2020
Phase: N/A
Study type: Interventional

The aim of this study to investigate the effects of connective tissue massage (CTM) on pain, intestinal peristaltism and functionality after total laparoscopic (TLH) or abdominal hysterectomy (TAH). Patients who underwent TLH randomly group as TLH-CTM (n=15) and TLH control (n=16), and TAH randomly group as TAH-CTM (n=14) and TAH control (n=15). The postoperative daily monitoring sheet, Visual Analogue Scale (VAS), time of intestinal peristaltism employees to collect research data.

NCT ID: NCT05269628 Recruiting - Pain Clinical Trials

Mechanisms of Cannabidiol in Persons With MS: the Role of Sleep and Pain Phenotype

Start date: March 25, 2022
Phase: Phase 2
Study type: Interventional

The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better sleep.