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Pain, Postoperative clinical trials

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NCT ID: NCT02644031 Recruiting - Pain, Postoperative Clinical Trials

Evaluation of Post-endodontic Pain After Root Canal Treatment With Two Rotary Systems : Mtwo & Safe-sider

Start date: December 2015
Phase: N/A
Study type: Interventional

Post-endodontic pain (PP) still is major problem for endodontic patients, analgesics are routinely prescribed. Incidence of PP is reported extensively, and reviewed. PP is a complicated multi factorial process and is affected by factors related to patients, to the tooth and to the skills and experience of the dentist and because of that, if the interrelation of these factors is not considered in a PP, study data might be confusing. Any study trying to evaluate the effect of a specific technique or new device in the incidence or characteristics of PP should control all the confounding factors that have been described to be involved in the tested outcome. reports mention a variable prevalence of PP, ranging from 82.9 to 10.6%. These variations are because of the differences in study methods, and treatment procedures after root canal treatment, selection of patients or experience and skills of the dentists, vary when different studies are compared. Many studies had confirmed that chemomechanical debridement of the root canal results in extrusion of dentinal chips, pulp tissue fragments, necrotic tissues, microorganisms, and root canal irrigants through the apical foramen. All preparation techniques and instruments, regardless of maintaining shorter working length of the apical terminus have reported to be related with extrusion of infected debris, and some of them extruded less material and others extruded more. Periapical inflammation and postoperative flare-ups may result from apical extrusion of debris that is also referred to as the "worm" of necrotic debris A common outcome of the studies examining the amount of apically extruded debris was that the techniques involving a push-pull filing motion usually produce a greater mass of apical debris than those have rotational action Files which has reciprocating and in-and-out filing motion, may act as a piston, extruding more debris and irrigants. While the file with continuous rotation motion like a screw conveyor improving transportation of dentinal chips and debris coronally. In this study, investigators compare post-endodontic pain between these two systems. Mtwo ( continuous rotation system) with safe-sider (reciprocating system). Therefore, the aim of this study is Evaluation of post-endodontic pain after root canal treatment with two rotary systems: Mtwo & safe-sider

NCT ID: NCT02643394 Completed - Postoperative Pain Clinical Trials

Efficacy of Oral vs. Intravenous Acetaminophen

Start date: August 17, 2015
Phase: Phase 4
Study type: Interventional

The comparative efficacy of intravenous (IV) to oral (PO-'per os') acetaminophen in the management of postoperative pain is understudied and largely unknown. In this observer blinded randomized clinical trial, investigators aim to determine the comparative efficacy of PO (preoperative) vs. IV (intraoperative) acetaminophen in a sinus surgery population.

NCT ID: NCT02642796 Completed - Postoperative Pain Clinical Trials

Transcutaneous Nerve Stimulation for Post-operative Acute and Chronic Pain

Start date: March 2013
Phase: N/A
Study type: Interventional

Aim of the study to assess the efficacy of two modes of transcutaneous electrical nerve stimulation (TENS) on relief of postoperative acute pain after hip fracture surgery.

NCT ID: NCT02642497 Completed - Postoperative Pain Clinical Trials

Local Ketamine Instillation for Postoperative Analgesia

Start date: August 2015
Phase: Phase 2/Phase 3
Study type: Interventional

This study aims at exploring the analgesic efficacy, and safety of Ketamine instillation into the wound of total thyroidectomy compared to placebo,and to systemic ketamine administration (I.M. injection of the same dose) with respect to postoperative VAS, first request of analgesia, total opioid consumption, and with respect to possible side effects.

NCT ID: NCT02639741 Completed - Postoperative Pain Clinical Trials

Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia

Start date: November 2014
Phase: Phase 4
Study type: Interventional

The investigators designed a randomized double-blind placebo-controlled trial to evaluate the effect of preoperative single dose of oral melatonin and vitamin C administration on postoperative analgesia in patients undergoing elective major abdominal surgery.

NCT ID: NCT02633969 Completed - Pain, Postoperative Clinical Trials

Study of Indomethacin Capsules to Treat Pain Following Surgery in Children Ages 6 to <17 Years of Age

Start date: December 2015
Phase: Phase 2
Study type: Interventional

The purposes of this study are to evaluate the safety and tolerability and to model the single-dose pharmacokinetic profile of indomethacin capsules low dose and high dose in children ages 6 to <17 years experiencing mild to moderate acute postoperative pain.

NCT ID: NCT02630849 Completed - Clinical trials for Chronic Postoperative Pain

Does a Multimodal no‐Compression Suture Technique of the Intercostal Space Reduce Chronic Post‐Thoracotomy Pain?

Start date: October 2011
Phase: N/A
Study type: Interventional

Chronic post-thoracotomy pain is a significant adverse outcome of thoracic surgery. transcollation technology evaluated with a prospective randomized trial the effect of a multimodal no-compression suture technique of the intercostal space on postoperative pain occurrence in patients undergoing mini-thoracotomy. Patients undergoing a muscle-sparing lateral mini-thoracotomy for different thoracic diseases were randomly divided into two groups:one group received intercostal muscle flap harvesting and pericostal no-compression "edge" suture (IMF group), and the second group received a standard suture technique associated with an intrapleural intercostal nerve block (IINB group). The aim of the study was to demonstrate that the multimodal no-compression suture technique is a rapid and feasible procedure reducing early and chronic post‐thoracotomy pain intensity.

NCT ID: NCT02630498 Terminated - Chronic Pain Clinical Trials

Preventing Chronic Post Surgical Pain After Limb Surgery

PCPSPAULS
Start date: August 2015
Phase: N/A
Study type: Interventional

This is a non-randomized prospective study. Patients undergoing upper extremity and shoulder surgical procedures after trauma at SJHC and LHSC will be divided in to two groups. The first group will include those who receive a single shot brachial plexus (interscalene, supraclavicular, infraclavicular and axillary) block with or without general anesthesia. The second group will be the control group and include those patients who receive general anesthesia only, without any block whether due to the preference of patient or the surgeon

NCT ID: NCT02626533 Active, not recruiting - Pain Clinical Trials

Persistent Postoperative Pain and Joint Stiffness After Total Knee Arthroplasty Performed for Osteoarthritis

Pain+Stiffness
Start date: December 2015
Phase:
Study type: Observational

Persistent pain and joint stiffness after surgery may interfere with recovery and adversely affect quality of life in up to 40% of patients who have undergone total knee arthroplasty. There is growing evidence that inflammation as well as other medical and psychological factors may be associated with osteoarthritis severity, progression, and associated pain severity. This study aims to identify clinical, biological, and psychological factors that contribute to and predict the development of these complications. Identification of such factors may allow us to target preventative measures to the patients at highest risk of persistent postoperative pain and joint stiffness.

NCT ID: NCT02625753 Completed - Myopia Clinical Trials

Codeine Plus Paracetamol Versus Placebo for PRK Post-operative Pain

Start date: November 2014
Phase: Phase 3
Study type: Interventional

Compare the use of codeine/paracetamol against placebo for pain control after cornea photorefractive keratectomy (PRK).