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Ketamine Treatment for PTSD and MDD in TBI

Major Depressive Disorder Clinical Trial

Official title:
Examining the Efficacy and Safety of Subanesthetic Ketamine on Depression and Post-traumatic Stress Among Veterans With Mild and Moderate Traumatic Brain Injury

Clinical Trial Summary

The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI). The main questions it aims to answer are: - Efficacy of ketamine to reduce symptoms of depression and/or PTSD - Safety of ketamine to treat depression and/or PTSD in TBI Participants will be randomly assigned to receive either ketamine or midazolam (active placebo) twice a week for 3 weeks. During participation, subjects will be interviewed, have lab tests, and complete rating scales, and questionnaires.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06228391
Study type Interventional
Source Minneapolis Veterans Affairs Medical Center
Contact Paulo Shiroma, MD
Phone 612-467-2264
Email paulo.shiroma@va.gov
Status Not yet recruiting
Phase Phase 2
Start date March 2024
Completion date March 2027
View Details
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