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Traumatic Brain Injury clinical trials

View clinical trials related to Traumatic Brain Injury.

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NCT ID: NCT03771950 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Early Team Based Neuro-rehabilitation After Traumatic Brain Injury - a Pilot Study

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

The aim is to evaluate the study design, procedure and measurements in a randomised controlled pilot study.

NCT ID: NCT03761641 Recruiting - Clinical trials for Traumatic Brain Injury

Pilot Study of NeuroTriage Device in Patients With Potential Brain Injury and/or Impairment

Start date: March 2015
Phase:
Study type: Observational

This protocol is aimed at collecting oculomotor response data from a variety of brain injuries and impairments, and to secondarily evaluate the functionality and ease of use of the NeuroTriage device in the ED in patients with any presumed brain injury and/or impairment. For example, prior studies in adolescents with a concussion have shown that they tend to overshoot the pattern when asked to follow the movement of the lights in the binoculars

NCT ID: NCT03739307 Not yet recruiting - Pain Clinical Trials

Characterization & Treatment of Chronic Pain After Moderate to Severe TBI

Start date: April 2019
Phase:
Study type: Observational

This is a five year multi-site, cross sectional, observational study designed to examine chronic pain and pain treatment after moderate to severe TBI.

NCT ID: NCT03734289 Recruiting - Dementia Clinical Trials

Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With AD and TBI

Start date: February 1, 2017
Phase: N/A
Study type: Interventional

To reduce care resistant behaviors (CRB) among people with dementia residing in nursing homes, to a distance-learning education, training, and coaching program for family caregivers of people with dementia or TBI; assess the efficacy of the intervention for reducing frequency or severity of CRB-triggered symptoms of agitation, aggression, and irritability; assess the efficacy of the intervention for improving quality of life of patients, caregivers, and families; and determine how patient and caregiver characteristics influence the effectiveness of the intervention. 5. Evaluate how the intervention affects the health care costs of people with dementia or TBI.

NCT ID: NCT03727334 Not yet recruiting - Clinical trials for Traumatic Brain Injury

Offsetting Hippocampal Degeneration in m-sTBI

m-sTBI
Start date: November 2018
Phase: N/A
Study type: Interventional

The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain structures.

NCT ID: NCT03724136 Recruiting - Alzheimer Disease Clinical Trials

Alzheimer's Autism and Cognitive Impairment Stem Cell Treatment Study

ACIST
Start date: October 24, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is to evaluate the use of autologous Bone Marrow Derived Stem Cells (BMSC) as a means to improve cognitive impairment as occurs in Alzheimer's Disease and other dementias and to improve behavior and socialization issues which occur in adult Autism Spectrum Disorder. The use of Near Infrared Light, in conjunction with the use of BMSC, will also be assessed.

NCT ID: NCT03723434 Recruiting - Healthy Clinical Trials

Physiology of Interregional Connectivity in the Human Brain

Start date: May 31, 2017
Phase: N/A
Study type: Interventional

The purpose of this study is to understand the physiology of connectivity between cortical regions in the human brain in healthy participants and in patients with white matter lesions. Specifically, the investigators will examine the effects of paired associative stimulation (PAS) which consists in delivering brief (< 1 ms) current pulses separated by a short millisecond-level time interval ("asynchrony") to two cortical areas. The used techniques are all non-invasive and considered safe in humans: transcranial magnetic stimulation (TMS), electroencephalography (EEG), magnetic resonance imaging (MRI), and functional MRI (fMRI). Based on prior literature in animals and human studies, it is hypothesized that PAS may increase or decrease effective connectivity between the stimulated areas depending on the asynchrony value. The main outcome measure is source-resolved EEG responses evoked by single-pulse TMS; this is a more direct measure of neuronal changes occurring at the targeted cortical area than motor evoked potentials (MEPs) or sensor-level EEG responses used in previous studies.

NCT ID: NCT03704116 Recruiting - Clinical trials for Traumatic Brain Injury

Executive Function Training Intervention for Chronic Traumatic Brain Injury

Start date: July 16, 2018
Phase: N/A
Study type: Interventional

Traumatic Brain Injury (TBI) is a prevalent disorder developed by military personnel. While some individuals recover function within months after injury, others continue to suffer from cognitive problems months to years later and may not become evident immediately, particularly for the recently transitioned veteran. Chronic TBI cases may include persistent difficulties in cognition that negatively impact employment and personal relationships. The investigators will test and evaluate software-based interventions aimed at improving cognition in veterans experiencing everyday life cognitive deficits due to TBI. The interventions will be administered on a computer using a tele-health approach. Two conditions will be compared, an active condition challenging memory, inhibitory control and planning, and a context-matched control condition that is lower on these challenge levels.

NCT ID: NCT03701620 Recruiting - Clinical trials for Traumatic Brain Injury

Heart Rate Variability in Children With Traumatic Brain Injury

HRV-TBI
Start date: January 1, 2018
Phase:
Study type: Observational

Using a prospective cohort of children admitted to the PICU, the investigators will determine HRV monitoring is feasible, if a decreased HRV in the 7 days following moderate or severe TBI in children is associated with a worse outcome 6 months post-TBI and investigate HRV as a tool that can predict adverse events (neurological crisis) within 2 days following TBI.

NCT ID: NCT03701594 Recruiting - Clinical trials for Traumatic Brain Injury

The Impact of Yoga-based Physical Therapy for Individuals With Traumatic Brain Injury

Start date: October 1, 2018
Phase: N/A
Study type: Interventional

This study aims to explore if a yoga-based physical therapy session would promote improved (increased) heart rate variability in subjects with traumatic brain injuries. The results of this pilot study may inform a larger-scale study of the effects of regular participation in a yoga-based program as an adjunct to traditional physical therapy. The secondary objective is to determine whether a yoga-based physical therapy session would impact anxiety, fatigue, or agitation and/or sleep quality. The study will enroll up to 30 inpatient subjects on a rolling basis as they are admitted with traumatic brain injury over a 12 month period at the Shirley Ryan AbilityLab. Each person in the study will participate in three conditions in a random order across three days: 1 hour of yoga-based physical therapy session in a group setting,1 hour of one-on-one conventional physical therapy, and 1 hour of seated rest in a relaxing environment in a group setting. The hypothesis is that individuals who participate in 1 hour of a yoga-based physical therapy session in a group setting will demonstrate a significant improvement in heart rate variability, anxiety, fatigue, and agitation after the session when compared to the same measures after 1 hour of a conventional physical therapy session and 1 hour of seated rest in a relaxing environment. Sleep will also be assessed with an activity monitor.