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Clinical Trial Summary

LPS Challenge in Individuals with Major Depressive Disorder


Clinical Trial Description

The aim of this project is to understand the biological differences between two distinct subtypes of depression, patients with and without inflammation as defined by c-reactive protein (CRP). Using a double-blinded, parallel group, placebo-controlled design, participants will be phenotyped before and after a low-dose lipopolysaccharide (LPS) challenge designed to perturb the immune system and trigger a transient, mild inflammatory response. This experimental design will allow for the delineation of the homeostatic mechanisms underlying sensitivity to inflammation-related depression. Low-dose LPS has been used by multiple groups to safely induce transient inflammatory responses in humans. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03142919
Study type Interventional
Source Laureate Institute for Brain Research, Inc.
Contact
Status Completed
Phase Phase 2
Start date September 7, 2017
Completion date December 1, 2020

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