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Clinical Trial Summary

The goal of this clinical trial is to examine the use of sedative ketamine to treat depression and post-traumatic stress disorder (PTSD) in Veterans with mild to moderate traumatic brain injury (TBI). The main questions it aims to answer are: - Efficacy of ketamine to reduce symptoms of depression and/or PTSD - Safety of ketamine to treat depression and/or PTSD in TBI Participants will be randomly assigned to receive either ketamine or midazolam (active placebo) twice a week for 3 weeks. During participation, subjects will be interviewed, have lab tests, and complete rating scales, and questionnaires.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06228391
Study type Interventional
Source Minneapolis Veterans Affairs Medical Center
Contact Paulo Shiroma, MD
Phone 612-467-2264
Email paulo.shiroma@va.gov
Status Not yet recruiting
Phase Phase 2
Start date March 2024
Completion date March 2027

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