Major Depressive Disorder Clinical Trial
Official title:
A Comparison of Two Antidepressant Tapering Regimens
The purpose of this study is to compare two ways to stop taking an antidepressant medication and determine whether a faster or slower taper is better tolerated.
As abrupt cessation of antidepressant medication can cause distressing symptoms (including
and not limited to worsened mood, irritability/agitation, anxiety, dizziness, confusion, and
headache), the aim of this study is to compare the tolerance of two tapering regimens with
the hypothesis that tapering the antidepressant dose over the course of two weeks will yield
less discontinuation symptoms than a one week taper regimen. Additionally, it is suspected
that discontinuing medications that inhibit the serotonin transporter , such as selective
serotonin reuptake inhibitors (SSRI) and serotonin norepinephrine reuptake inhibitors (SNRI)
will have a greater difference in the frequency of discontinuation symptoms between the two
and one-week tapering regimens versus antidepressants that don't inhibit serotonin
transporter.
Demographic and clinical features will also be identified that may predict discontinuation
symptoms with the hypothesis that patients on SSRIs and SNRIs may experience more
discontinuation symptoms versus patients on non-SSRI/SNRI medications. Whether or not the
treatment duration is positively associated with the number of discontinuation symptoms will
also be determined.
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