Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease

Heart Failure Clinical Trial

Official title: Water-and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease, Evaluated by the Excretion of Aquaporin-2 and Epithelial Sodium Channels in the Urine

Status Recruiting

Clinical Trial Summary

The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.

Clinical Trial Description

The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension) ;

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Aortic Stenosis
• Aortic Valve Stenosis
• Coronary Artery Disease
• Healthy Volunteers
• Heart Diseases
• Heart Failure
• Hypertension, Pulmonary
• Ischemic Heart Disease
• Lung Diseases
• Myocardial Ischemia
• Pulmonary Hypertension

• NCT number: NCT00830726
• Study type: Observational
• Source: Kolding Sygehus
• Contact: Ole Nyvad, M.D.
• Phone: +45 76362257
• Email: ole.nyvad@slb.regionsyddanmark.dk
• Status: Recruiting
• Phase: N/A
• Start date: February 2009
• Completion date: February 2012