Heart Failure Clinical Trial
Official title:
Immunoadsorption With Subsequent Immunoglobulin Substitution for Patients With Heart Failure After Myocardial Infarction
The purpose of this study is to investigate, if immunoadsorption of autoantibodies with subsequent substitution of immunoglobulins is able to improve cardiac function of patients with heart failure after myocardial infarction and presence of cardiac autoantibodies.
Heart failure due to coronary heart disease (CHD) remains one of the most frequent causes of
death. Left-ventricular ejection fraction < 30% is associated with a 5-year mortality > 70%.
Therefore, new strategies and therapies towards treatment of heart failure are needed.
Heart failure due to left ventricular dysfunction can develop in CHD beyond the area of
myocardial infarction. Some of these patients develop myocardial autoantibodies, which have
been shown to exert a negative inotropic effect. Their elimination by immunoadsorption has
been shown to improve left ventricular function in dilatative cardiomyopathy.
Immunoglobulins are substituted to minimize infection risk at a level, which has been shown
not to effect cardiac function. This intervention might also ameliorate cardiac function in
patients with heart failure due to other origins. This study therefore aims to evaluate the
effect of immunoadsorption with subsequent immunoglobulin substitution.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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