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Filter by:The main objective of this trial is to investigate the induction effect of multiple oral doses of BI 1015550 on the pharmacokinetics of nintedanib or pirfenidone.
This study aims to evaluate the effects of iclepertin in the range of therapeutic to supra-therapeutic exposures on the (QT/QTc): Electrocardiogram (ECG) time interval from the start of the QRS complex (ECG time interval) to the end of the T wave / QT interval corrected for heart rate, e.g. using the method of Fridericia or Bazett interval and other ECG parameters.
The Real Time MRI Rapid Flash sequence is particularly interesting for the study of moving organs and joints. This sequence will make it possible to characterize normal and pathological temporomandibular joint movements by MRI.
During a submaximal task, gradual muscle fatigue occurs, which inevitably results in a decline in performance (mechanical failure). Elite athletes are known to employ unconscious compensatory strategies during fatiguing submaximal tasks in an attempt to delay the onset of mechanical failure as long as possible. The purpose of this study was to gain valuable insight into the strategies used by elite swimmers to cope with mechanical failure. Twenty-two swimmers were subjected to a swim test consisting of swimming as long as possible at a predetermined and controlled pace. A light strip positioned at the bottom of the pool allows athletes to get feedback on which gait to keep. The kinematics (stroke rate, stroke length, and efficiency index) and electrical activity of 10 muscle groups were analyzed and compared at the beginning of the test (non-fatiguing conditions), just before the athlete lost the ability to maintain the predetermined pace (pre-mechanical failure), and after the athlete lost the ability to maintain the pace (mechanical failure). It is hypothesized that as fatigue becomes more pronounced and the point of inability to maintain a predetermined speed is approached, increased EMG activity will occur in key muscles while other muscle groups may show more obvious signs of fatigue. In addition, changes in the rhythm and coordination of upper limb movements may occur.
Study Purpose: To examine the acute effects of antioxidant supplementation on energy use during a single bout of exercise in apparently healthy adult men and women. Specifically this study examined the acute effect of MitoQ on: 1. cardiopulmonary responses to submax and maximal exercise 2. Energy expenditure and fat/carbohydrate oxidation during sub maximal exercise. In a double-blind, randomized, placebo controlled, cross-over study design, participants performed 2 experimental trials which differed only in the supplement consumed (MitoQ or Placebo). Participants performed identical exercise protocols which consisted of a series of submaximal workloads followed by a ramp protocol to volitional exhaustion.
EEG Measures during Visual Search Task. In this line of research, the researchers having participants receive a positive (target) template cue, negative (distractor) template cue, or neutral (non-informative) template cue. Note: This is a re-analysis of previously collected data.
Identify and test thresholds, specificity and sensitivity for a potential cancer associated biomarker protein, FGF19, (and associated markers) for detection in human blood in the blood of breast and colorectal in cancer patients, and see if occurs at higher rates than healthy controls
This is a comprehensive pathophysiological study assessing various gastric functions in patients with diabetes mellitus. The investigators aim to examine the stomach with various measurement devices to gain information about its different functions and malfunctions. After the initial measurements, the examinations will be repeated after a year in each patient. Changes in the measurement values will be examined and their relations to each other and to the overall health of the patients will be investigated. For example it is hypothesised that diabetic patients also suffering from functional dyspepsia or gastroparesis will also show some changes in the function of the pyloric muscle.
GI disorders are influenced by the gut microbiome. To date, sampling of the small intestine in GI disorders has been limited. The investigators plan to sample the small intestinal contents during endoscopy for research purposes.
Purpose: The study is designed to investigate cardiovascular effects of young healthy human subjects exposed to wood smoke. Participants: Approximately 30 young (18-35 years old) healthy subjects to complete. Procedure (methods): After consenting to participate in the study, participants will undergo exposure to approximately 500 μg/m^3 wood smoke for 2 hours while exercising intermittently (15 min exercise followed by 15 min rest) on a stationary bike at a workload sufficient to maintain approximately 12 L/min/m^2 minute ventilation. There are a total of three separate exposure sessions. During the first two exposure sessions, participants will wear, in randomized order, a half-face elastomeric respirator fitted with particulate filters alone (hereafter referred to as "PM mask") or particulate filters and a hydrocarbon sorbent (hereafter referred to as "VOC mask"). During the third exposure session, participants will be randomly assigned to wear either a surgical mask or an N95 respirator. Venous blood samples and measurements of lung, cardiac and vascular function will be made prior to and immediately following each exposure. Induced sputum samples and nasal epithelial lining fluid will be collected approximately 24 hours post each exposure.