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NCT ID: NCT03729284 Not yet recruiting - Healthy Clinical Trials

A Study of Duloxetine Hydrochloride Hard Gelatinous Capsule Compared To Cymbalta

Start date: February 25, 2019
Phase: Phase 4
Study type: Interventional

In Brazil, duloxetine is currently available as hard gelatinous capsule with delayed release microgranules for oral administration containing enteric-coated pellets of 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 30 mg or 60 mg of duloxetine (Cymbalta®), respectively. The Sponsor has developed a hard gelatinous capsule with delayed release microgranules formulation containing enteric-coated pellets of 33.7, or 67.3 mg of duloxetine hydrochloride equivalent to 30, or 60 mg of duloxetine, respectively. The purpose of this study is to verify through a single dose study, if the test formulation of duloxetine (60 mg) is bioequivalent to the reference formulation (Cymbalta® 60 mg) when administered with the same dosage and under fasted conditions in healthy male research subjects.

NCT ID: NCT03728751 Completed - Healthy Clinical Trials

Optimal Time for In-situ Dry Needling to Affect the Autonomic Nervous System

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

Assessing for optimal time dry needles need to remain inside the body to have positive effect on the nervous system

NCT ID: NCT03728101 Recruiting - Healthy Clinical Trials

Drug Interaction Study of Simvastatin and Dabigatran

Start date: November 16, 2018
Phase: Phase 1
Study type: Interventional

The aim of the study is to evaluate the effect of simvastatin on the pharmacokinetics and pharmacodynamics of dabigatran in healthy male adults

NCT ID: NCT03726671 Recruiting - Healthy Clinical Trials

Choline Nutritional Status: Development of a Biomarker Panel

Start date: November 2018
Phase: N/A
Study type: Interventional

People who eat diets low in choline should deplete their choline (Cho) stores, and measurements of Cho pool size using isotope dilution should reflect this depletion. Investigators will identify a biomarker panel that correlates well with measured Cho pool size across the range of different degrees of depletion.The investigators propose that, as body stores of Cho diminish, cells and organs will reach the point when metabolism/function in the cell is altered, and that this will result in a progression of changes in biomarkers that reflect Cho status.

NCT ID: NCT03726125 Not yet recruiting - Healthy Clinical Trials

A Study of LY3374849 in Healthy Participants

Start date: November 20, 2018
Phase: Phase 1
Study type: Interventional

The aim of this trial is to evaluate the safety and tolerability of the study drug known as LY3374849, when given as an injection to healthy participants. The study will also investigate how quickly the body absorbs and gets rid of LY3374849 and how it affects the levels of blood sugar in comparison to insulin degludec, after a single dose is given by injection. Participation in this study includes screening, which is required within 28 days before start of study, one study period (approximately 1 week), and a follow up at least 28 days after receiving study drug.

NCT ID: NCT03725462 Recruiting - Healthy Clinical Trials

Evaluation of Electrophysiological Signal Measured by Smart Textile CE-marked

STREAM
Start date: October 16, 2017
Phase: N/A
Study type: Interventional

The aim is to evaluate the performance of Cardioskin and Neuronaute, two connected medical devices CE-marked, manufactured by Bioserenity. It's an open monocentric comparative clinical study, where subjects will test the Cardioskin device and/or the Neuronaute device.

NCT ID: NCT03725241 Recruiting - Healthy Clinical Trials

Effects of Glutathione on Immunity in Individuals Training for a Marathon

Start date: October 29, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to determine the effects of glutathione supplement on the immune cell response and symptomatology of upper respiratory health, and antioxidant capacity in healthy people in exercise-induced model.

NCT ID: NCT03725189 Not yet recruiting - Healthy Clinical Trials

Photophlethysmography Evaluation of Pulse Waveform

Start date: January 1, 2019
Phase: N/A
Study type: Interventional

Aim 1. To explore a novel, non-invasive PPG technology for purposes of monitoring heart rate variability and pulse waveform by harmonic resonance analysis. Aim 2. To analyze collected data to determine whether it provides useful information about other measures of underlying health.

NCT ID: NCT03725072 Not yet recruiting - Healthy Clinical Trials

Human Absorption, Distribution, Metabolism and Excretion (ADME) of [14C]-Evobrutinib

Start date: October 30, 2018
Phase: Phase 1
Study type: Interventional

The purpose of the study is to determine the absorption, metabolism, and excretion of [14C]-evobrutinib in healthy participants

NCT ID: NCT03723746 Recruiting - Healthy Clinical Trials

A Study to Evaluate the Safety and Tolerability of JNJ-67670187 in Healthy Participants

Start date: October 25, 2018
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the safety and tolerability of single and multiple day dose of JNJ-67670187 compared to placebo.