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Healthy clinical trials

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NCT ID: NCT03310411 Not yet recruiting - Healthy Clinical Trials

A Study of Lasmiditan When Given With Sumatriptan in Healthy Participants

Start date: October 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess whether taking lasmiditan and sumatriptan together will have any additional effects on heart rate and blood pressure compared to taking lasmiditan and sumatriptan individually. This study will also look at the amount of study drug that gets into the blood stream and how long it takes the body to get rid of it when these two drugs are taken together. This study will last about 21 days, not including the screening. Participants will spend 16 days/15 nights in the clinical research unit (CRU) followed by follow-up. Screening is required within 28 days prior to the start of the study.

NCT ID: NCT03310073 Completed - Healthy Clinical Trials

Immunogenicity and Safety Profile of Primary Dose of bOPV Bio Farma Given Simultaneously With Pentabio And IPV

Start date: July 2016
Phase: Phase 4
Study type: Interventional

This study is to assess protectivity following four doses of bOPV which given simultaneously with Pentabio® and 1 dose of IPV at the 4th visit

NCT ID: NCT03309566 Completed - Healthy Clinical Trials

Bioequivalence Study of Two Formulatiosns With the Asscociaton of Efavirenz, Emtricitabine and Tenofovir

Start date: September 4, 2016
Phase: Phase 4
Study type: Interventional

Bioequivalence study of two formulations containing a fixed dose combination of 600 mg Efavirenz, 200 mg Emtricitabine and 300 mg Tenofovir Disproxyl Fumarate in coated tablets under a single-dose, two-way crossover design.

NCT ID: NCT03309124 Not yet recruiting - Healthy Clinical Trials

Effect of White Potatoes on Glycemic Response and Satiety in Older Adults

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The purpose of the present study is to explore the influence of cooking methods on post-prandial glycaemia and its impact on satiety across the lifespan in healthy older adults.

NCT ID: NCT03308669 Not yet recruiting - Healthy Clinical Trials

A Study of Lasmiditan in Healthy Participants When Co-administered With Topiramate

H8H-MC-LAHT
Start date: October 2017
Phase: Phase 1
Study type: Interventional

This study will assess the safety, tolerability and blood concentrations of lasmiditan and topiramate together compared to lasmiditan and topiramate separately. Information about any side effects that may occur will be collected. Participants will be admitted to the Clinical Research Unit (CRU) one day prior to the start of the study and will remain through Day 14. This study is expected to last approximately 25 days, not including screening. Screening is required within 28 days prior to the start of the study.

NCT ID: NCT03308383 Not yet recruiting - HEALTHY Clinical Trials

Normal Echocardiographic Parameters of Indian Population and Comparison With the ASE Reference Range

TTE IN INDIAN
Start date: October 2017
Phase: N/A
Study type: Interventional

Echocardiography forms one of the most used modality in the evaluation of cardiac anatomy and functions in both patients with cardiac symptoms and in healthy individuals for occupational and research purpose. The interpretation of any medical investigation including echocardiographic report is based on its comparison with the normal range for that parameter, which is known to vary depending on the age, sex, body surface area (BSA), ethnicity and race. Since most of the medical/surgical treatment decisions are made based on the echocardiographic reports, the interpretation of results should be accurate. Even though there are many studies defining reference ranges of echocardiographic parameters, most of them were based on studies conducted in Western and European population, who shows considerable difference in their anthropometric measurements from the Indian population. Hence for the accurate diagnosis of any cardiac abnormalities, the reference values should have been derived from studies conducted in population of that particular race and ethnicity who are free of risk factors for the cardiac disease. Hence the investigator planned to conduct a study to determine the normal Echocardiographic parameters and compare it with the reference range of established by American society of echocardiography (ASE).

NCT ID: NCT03308110 Recruiting - Healthy Clinical Trials

Bioavailability and Food Effect Study of Two Formulations of PF-06650833

Start date: September 11, 2017
Phase: Phase 1
Study type: Interventional

Bioavailability and food effect of 2 formulations of PF-06650833 in healthy volunteers.

NCT ID: NCT03307681 Not yet recruiting - Healthy Clinical Trials

Effect of White Potatoes on Glycemic Response and Satiety in Children

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

The purpose of the present study is to explore the influence of cooking methods on post-prandial glycaemia and its impact on satiety in children.

NCT ID: NCT03307252 Not yet recruiting - Healthy Clinical Trials

This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men

Start date: October 9, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this trial is to investigate the relative bioavailabilities of digoxin, furosemide, metformin and rosuvastatin given as a cocktail alone and as a cocktail together with the following drug transporter inhibitors: Part 1: verapamil (P-gp) and rifampin (OATP1B1/1B3) Part 2: cimetidine (OCT2/MATE) Part 3: probenecid (OAT1/3) The secondary objective is to investigate other potential changes in pharmacokinetics (e.g. in clearance, volume of distribution, etc.) of digoxin, furosemide, metformin and rosuvastatin given as a cocktail alone and as a cocktail together with the inhibitors describe above.

NCT ID: NCT03306667 Not yet recruiting - Healthy Clinical Trials

Clinical Pharmacology of FYU-981 (Subjects With Hepatic Insufficiency)

Start date: October 2017
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the pharmacokinetics, pharmacodynamics and safety after single oral administration of FYU-981 to subjects with hepatic insufficiency and with normal hepatic function.