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Healthy clinical trials

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NCT ID: NCT03884400 Not yet recruiting - Healthy Clinical Trials

Distribution of Biospecimens From Biorepositories/Biobanks for Research Use

Start date: June 1, 2019
Phase:
Study type: Observational

This protocol seeks to assist biorepositories/biobanks in distributing their stored specimens and data to researchers that will actually utilize them to advance medicine and technology.

NCT ID: NCT03883165 Not yet recruiting - Healthy Clinical Trials

How do the Neck Muscles Influence Head Acceleration During Sport-associated Impact Events in High School Athletes?

Start date: March 2019
Phase: N/A
Study type: Interventional

Sport-related concussion is a common and serious injury that can affect athletes of all ages in any sport. The purpose of this project is to study the effect of a 12-week manual resistance neck strengthening exercise program on participants' neck size and strength and how their heads and necks move during simulated sport-associated tasks. This study will help determine if greater neck strength may lower an athlete's risk of sport-related concussion. Each healthy male and female soccer athlete between the ages of 13-19 enrolled in the study will participate for approximately four months. Study participation includes routine visits with various assessments (i.e. certain body measurements, magnetic resonance imaging, ultrasound) in addition to the strengthening exercise program.

NCT ID: NCT03882424 Completed - Healthy Clinical Trials

A Study to Compare Pharmacokinetic and Safety of TRS003 to China-approved Bevacizumab and US-licensed Avastin®

Start date: June 12, 2018
Phase: Phase 1
Study type: Interventional

This is a 12-week, randomized, double-blind, single-dose pharmacokinetic (PK) study. Approximately 114 healthy male participants (screening occurred within 28 days prior to dosing) will be randomized 1:1:1 to either TRS003, China-approved bevacizumab, and US-licensed Avastin® groups. Study drug will be dispensed as a single 3 mg/kg dose for intravenous infusion within 90 minutes. PK and immunogenicity samples will be collected and safety will be assessed. The primary objective of this study was to demonstrate pharmacokinetic similarity between TRS003, China-approved bevacizumab and US-licensed Avastin®, as measured by AUC0-inf in healthy male participants after a single 3 mg/kg dose.

NCT ID: NCT03882255 Not yet recruiting - Healthy Clinical Trials

A Study of Ponesimod in Healthy Adult Participants Receiving Propranolol at Steady State

Start date: March 18, 2019
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to evaluate the effect of the up-titration regimen of ponesimod on heart rate (HR) and other electrocardiogram (ECG) parameters when administrated to healthy adult participants receiving propranolol at steady state.

NCT ID: NCT03880253 Not yet recruiting - Healthy Clinical Trials

Multiple Ascending Dose Study of CTP-692 in Healthy Volunteers

Start date: April 2019
Phase: Phase 1
Study type: Interventional

This study will assess in healthy male and female subjects the safety and pharmacokinetic (PK) profiles of 3 dose levels of CTP-692 following 7 days of dosing.

NCT ID: NCT03880136 Not yet recruiting - Healthy Clinical Trials

Food Effect Study of CTP-543 in Healthy Volunteers

Start date: March 2019
Phase: Phase 1
Study type: Interventional

Two period crossover study to assess the bioavailability of CTP-543 under fed and fasted conditions.

NCT ID: NCT03879213 Recruiting - Healthy Clinical Trials

Acute Berry Intake on Metabolic Control and Cognitive Function

RRB3
Start date: September 17, 2018
Phase: N/A
Study type: Interventional

The objectives of this study are: 1. Evaluate the effects of acute dietary raspberry intake on metabolic-associated impairments in cognitive and psychomotor function in overweight/obese adults (55-70y) following a meal challenge 2. Evaluate the effects of acute dietary raspberry on measures of vascular function.

NCT ID: NCT03879187 Completed - Healthy Clinical Trials

Molecular and Hormonal Responses to Diet-Induced Insulin Resistance

Start date: March 2, 2015
Phase: N/A
Study type: Interventional

This study determined the effect of 7 days of high-fat overfeeding on whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function in 15 healthy young individuals.

NCT ID: NCT03878264 Recruiting - Healthy Clinical Trials

Absolute Bioavailability and Metabolism Study of CORT118335 in Healthy Male Participants

Start date: August 6, 2018
Phase: Phase 1
Study type: Interventional

This study will evaluate the absolute bioavailability of CORT118335 and determine the mass balance recovery, absorption, metabolism and elimination, and metabolite profile and identification of metabolite structures following a single oral dose of CORT118335 in healthy male participants.

NCT ID: NCT03878108 Not yet recruiting - Healthy Clinical Trials

Effects of Low Fat Versus Low Carbohydrate Diets on Energy Metabolism

Start date: March 27, 2019
Phase:
Study type: Observational

Background: Researchers want to learn how different diets affect hormone levels, body weight, energy expenditure, liver fat, and more. To do this, they will use specialized techniques and food plans. This is not a weight loss study. Objective: To better understand how low-fat and low-carbohydrate foods affect health. Eligibility: Men and women ages 18 50 who have a stable body weight and can exercise daily Design: Participants will have a screening visit that lasts 4 6 hours. It will include: Medical history Physical exam Fasting blood and urine tests Questionnaires Trying foods from the study Participants will be admitted to the Clinical Center and will stay for 4 weeks without leaving. They can have visitors. Participants will wear activity and glucose monitors throughout the study. They will be weighed daily and will complete daily exercise. They will eat 3 meals daily, plus snacks. They will give urine, saliva, and blood samples. They will fill out questionnaires and rate their hunger, appetite, and sense of taste. They will have body scans. For the scans, they will lie in a machine that takes X-ray pictures of the body. Participants will complete activities to measure how many calories they burn and how the diets affect them: Participants will drink special liquids to measure calories burned, sugar, and sense of taste. Participants will wear a plastic hood while resting. Participants will stay alone in a special room for 24 hours. Participants will eat a low-carb, high-fat diet for 2 weeks and a high-carb, low-fat diet for 2 weeks. Participants may be dismissed if they purposefully use the study to try to change their body weight. Sponsoring Institution: National Institute of Diabetes and Digestive and Kidney Diseases