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Filter by:A Randomized, Open-Label, Single-Dose Parallel Study to Evaluate the Pharmacokinetics, Safety and Tolerability of HCP1904 in Healthy Male Volunteers.
A single-center, open-label, randomized, two-period, crossover study design of pharmacokinetics and bioavailability in healthy Chinese subjects under fasting conditions.
The goal of this study is to establish parameters of gastric myoelectrical activity and heart rate variability in healthy human subjects and compare and contrast them to those with gastroparesis and functional dyspepsia, at baseline and following taVNS.
The goal of this work is to address increasing concerns about young children's digital media exposure and language outcomes by testing how the times course of word learning unfolds in digital environments and the cascading impact of digital media on vocabulary outcomes. The findings will have important implications for understanding when and where optimal word learning from media can occur.
This is a randomized, double-blind, and placebo controlled. 120 HV will be randomized to one of three ketamine arms, delivered in a bolus dose over one minute: low (0.086 mg/kg), medium (0.125 mg/kg), and high (0.23 mg/kg). Within each ketamine arm, subjects will be randomized to 4 days of TS-134 20 mg or placebo in a 5:3 ratio (25 TS-134:15 placebo). Following an outpatient Screening Period (up to 31 days), eligible subjects will undergo an up to 5-day inpatient Treatment Period. During the study, each subject will undergo a total of two ketamine sessions: a first session during the Screening Period and a second session on Day 4 of the Treatment Period, conducted at least 7 days apart. All randomized subjects will be dosed with TS-134 or placebo daily in a fed state for 4 days during the study, titrated to 20 mg over the first 2 days.
The core muscles contain various muscle groups that stabilize the shoulders, pelvis, and spine, and they play an important role as pivot points in extremity movements. It is known that core muscles stabilize the lumbar region and core stabilization affects muscle activation. İn addition conscious abdominal muscle activation during exercise performance is believed to promote greater scapular muscle activation through existing myofascial connections. Studies support the relationship between the scapular region and the core region. Another aspect of rehabilitation is the use of unstable surfaces with exercise, since it is possible to increase neuromuscular demand without placing further overload on the musculoskeletal system. Hypothesis originating from the investigation: H1: Exercises performed with core activation on stable surfaces activate the muscles around the scapula more than exercises performed without core activation. H2: Exercises performed with core activation on unstable surfaces activate the muscles around the scapula more than exercises performed without core activation. H3: Exercises performed with core activation on unstable surfaces activate muscle activation around the scapula more than exercises performed on stable surfaces. H4: Exercises performed without core activation on unstable surfaces activate muscle activation around the scapula more than exercises performed on stable surfaces.
This randomized controlled study aims to determine the effect of listening to music (LM), ball squeezing (BS), and performing mathematical operations (MO) in reducing the pain experienced during the first dressing in children aged 8-18 with appendectomy.
The purpose of this study is to investigate the safe wearability and basic functions of the multi-modality sensors fabricated in the PI lab.
This study is designed as a single centre, double blind, placebo controlled, randomized, SAD/FE/MAD, safety, tolerance and PK study of BMB-101 in healthy adult subjects. The study will be conducted as a 3-part study.
The main objectives of this study were to estimate the absolute bioavailability of ravulizumab/rHuPH20 subcutaneous (SC) and to assess the safety and tolerability of ravulizumab/rHuPH20 SC.