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Healthy clinical trials

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NCT ID: NCT05469126 Completed - Healthy Clinical Trials

A Drug Interaction Study of Clarithromycin and LY3502970 in Healthy Participants

Start date: August 1, 2022
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to determine the levels of study drug called LY3502970 in the blood stream when administered alone and in combination with clarithromycin in healthy participants. This study will last up to approximately 85 days for each participant.

NCT ID: NCT05469113 Completed - Healthy Clinical Trials

A Study of Effects of Selpercatinib (LY3527723) on Repaglinide in Healthy Participants

Start date: January 29, 2019
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the effect of selpercatinib on how fast repaglinide gets into the blood stream and how long it takes the body to remove it when administered in healthy participants. Information about safety and tolerability will be collected. The study will last up to 12 days.

NCT ID: NCT05469100 Completed - Healthy Clinical Trials

A Study of Effect of Selpercatinib (LY3527723) in Participants With Normal and Impaired Renal Function

Start date: December 19, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the amount of study drug that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment compared to healthy participants. The study will last up to 9 days, excluding screening.

NCT ID: NCT05468385 Completed - Healthy Clinical Trials

The Effects of taVNS on Inhibitory Control

Start date: May 1, 2022
Phase: N/A
Study type: Interventional

The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) improves the ability of inhibitory control in an emotional Go-Nogo task.

NCT ID: NCT05468164 Completed - Healthy Clinical Trials

A Study of Effect of Food and a Proton Pump Inhibitor on Selpercatinib (LY3527723) in Healthy Participants

Start date: May 31, 2018
Phase: Phase 1
Study type: Interventional

The main purpose of this study is to assess the effect of food on how fast selpercatinib gets into the bloodstream and how long it takes the body to remove it after a high-fat meal, and the effect of a change in gastric pH after multiple doses of omeprazole on how fast selpercatinib gets into the bloodstream and how long it takes the body to remove it when administered under fasted and fed conditions in healthy participants. The study will also evaluate the safety and tolerability of selpercatinib in healthy participants. The study will last up to 33 days excluding the screening period.

NCT ID: NCT05467761 Withdrawn - Healthy Clinical Trials

Bioavailability Study of Psilocybin in Normal Adults

Start date: June 2023
Phase: Phase 1
Study type: Interventional

The purpose of this research study is to compare an oral dose of psilocybin and an intravenous (IV) infusion of psilocybin to assess differences in how the drug is absorbed by the body, the psychedelic experience, and any side effects when taken by healthy adult participants. Participants can expect to be in the study for approximately 12 weeks.

NCT ID: NCT05467475 Completed - Healthy Clinical Trials

A Study in Healthy Men to Test How Esomeprazole Influences the Amount of BI 1819479 in the Blood

Start date: October 18, 2022
Phase: Phase 1
Study type: Interventional

The main objective of this trial is to investigate the effect of the proton pump inhibitor esomeprazole on the pharmacokinetics of BI 1819479 in plasma.

NCT ID: NCT05464628 Completed - Healthy Clinical Trials

Drug Interaction Study of ASC42 With Atorvastatin

Start date: August 8, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to determine whether ASC42 alters the pharmacokinetics of atorvastatin in healthy subjects.

NCT ID: NCT05463497 Completed - Healthy Clinical Trials

To Evaluate the Pharmacokinetic Drug Interactions, Safety and Drug Tolerance in Healthy Volunteers

Start date: January 17, 2022
Phase: Phase 1
Study type: Interventional

A randomized, open-label, multiple-dose, 2x3 crossover clinical trial to investigate the pharmacokinetic drug interaction of JW0201 and C2103 or C2104 after oral administration in healthy adults

NCT ID: NCT05463094 Completed - Healthy Clinical Trials

GXR RM China BE Study (Darmstadt - Jiangsu)

Start date: July 25, 2022
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess Bioequivalence (BE), pharmacokinetics (PK), safety and tolerability following single oral dose administrations between a Glucophage Extended Release, Reduced Mass (Glucophage XR RM) manufactured in Merck Jiangsu China (test product) and that manufactured in Merck Darmstadt Germany (reference product) administered under fasted and fed conditions.