Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression

Depression Clinical Trial

Official title:

Associations Between Depression and Cardiovascular Disease in Patients With Late Onset, Single Episode Major Depressive Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00818506
• Other study ID #: CPF-TAD-1
• Status: Completed
• Phase: N/A
• First received: January 6, 2009
• Last updated: November 20, 2012
• Start date: March 2009
• Est. completion date: June 2012

Study information

• Verified date: November 2012
• Source: University of Aarhus
• Contact: n/a
• Is FDA regulated: No
• Health authority: Denmark: Ethics Committee
• Study type: Observational

Clinical Trial Summary

Studies show that depression is a risk factor for the development of coronary artery disease (CAD). Furthermore there is an increased occurrence of depression in patients with CAD. Among other mechanisms atherosclerosis is believed to play a central role regarding these notable associations between depression and CAD. Moreover, patients with late onset major depression have an increased number of small lesions found in the white matter of the brain, the so-called white matter lesions. The main goal of this project is to examine if CAD is associated with depression and/or white matter lesions. CAD is evaluated using coronary CT angiography. Depression is evaluated using a semi-structured diagnostic interview. White matter lesions are quantified using cerebral magnetic resonance.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 55
• Est. completion date: June 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 50 Years to 70 Years

Eligibility

INCLUSION CRITERIA:

• Submitted to psychiatric hospital, district psychiatry or private psychiatrist because of major depressive disorder.

• Meets the criteria for Major Depressive Disorder, Single Episode as defined in the Diagnostic and Statistical Manual, fourth edition (DSM-IV) and the International Classification of Diseases (ICD-10).

• Age 50-70 years.

• Written informed consent.

• Caucasian.

EXCLUSION CRITERIA:

• Known, or anamnestic/objective signs of, organic brain disease.

• Organic, including symptomatic, mental disorders as (ICD-10: F00-F09).

• Dependence syndrome within the last 5 years (ICD-10: F1x.2) or current harmful use (ICD-10: F1x.1) of alcohol or other psychoactive substances.

• Schizophrenia, schizotypal and delusional disorders (ICD-10: F20-F29).

• Subject to force of law according to the danish law on psychiatry.

• Present risk of suicide.

• Previous cranial trauma resulting in unconsciousness for more than 2 minutes.

• Medical history of renal failure.

• Other conditions which contraindicate specific procedures in the project.

• Other conditions deemed to prevent the subject from completing the examination program.

• Does not want to participate.

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Cardiovascular Disease
• Cardiovascular Diseases
• Coronary Artery Disease
• Coronary Disease
• Depression
• Depressive Disorder
• Depressive Disorder, Major
• Major Depressive Disorder
• Myocardial Ischemia

Locations

Country	Name	City	State
Denmark	Center of Psychiatric Research, Aarhus University Hospital	Aarhus

Sponsors (6)

Lead Sponsor	Collaborator
University of Aarhus	Aarhus University Hospital, Augustinus Fonden, Danish National Research Foundation, The Ministry of Science, Technology and Innovation, Denmark, Vejle Hospital

Country where clinical trial is conducted

Denmark, 

External Links

•   Center of Psychiatric Research, Aarhus University Hospital