There are about 173942 clinical studies being (or have been) conducted in United States. The country of the clinical trial is determined by the location of where the clinical research is being studied. Most studies are often held in multiple locations & countries.
This is a three-arm pragmatic randomized controlled trial to test two interventions targeting clinical inertia in hypertension compared to control, followed by predictive modeling to identify factors that are associated with intervention responsiveness. Study investigators will use EHR data to identify providers of patients whose hypertension treatment was not intensified. Primary care physicians will then be randomized to one of three arms: pharmacist e-detailing, provider dashboards, or no intervention (control). After the intervention, the investigators will conduct virtual interviews with select providers from each arm. A predictive modeling approach will then be used to identify patient and provider characteristics that are associated with inertia and with responsiveness to each intervention.
Background: HCM is a genetic heart disease. It can cause fatigue, chest pain, or even death. For more than 50 years, a surgery called septal myectomy has been used to help people with this disease. Dr. Andrew G. Morrow originated the surgery and performed it more than 200 times at NIH starting in 1960. Researchers want to learn the long-term success of this surgery. Objective: To determine long-term survival at least 35 years after surgical myectomy at NIH and examine data for people who are confirmed to be deceased or alive. Eligibility: People who had surgical myectomy by Dr. Morrow from 1960 to 1983. Design: This study uses images and data that were obtained in the past. Many of the participants are deceased. Most of the others are no longer being followed at the NIH. The medical records of people treated by Dr. Morrow were microfiched. These records can be accessed at the NIH. The records will be searched for keywords to find participants for this study. Participants clinical data, such as lab testing and imaging, will be used. Other data collected as part of the original study will also be used. Researchers will use participants name, date of birth, and Social Security number to learn if they are alive or deceased. If they are deceased, researchers will try to find the age of death. Online databases and search engines will also be used. Survival data will be compared to data from the general U.S. population for the same time period. Data will be stored in a database that is password protected. The study will last about 1 year.
Children generally undergo induction of anesthesia by inhalation of sevoflurane. Children with Down Syndrome experience bradycardia with induction of anesthesia using sevoflurane. It is unknown if this bradycardia is isolate or results in hypotension, thus requiring treatment. Isolate bradycardia without hypotension does not require treatment and should be avoided as many of these patients have underlying cardiac anomalies.
The STEPS program is a wellness program where senior citizens are partnered with Doctor of Physical Therapy (DPT) students, who design individualized fitness plans for each senior participant. In both the Spring and Fall semesters, first- and second year DPT student teams provide guided interventions based upon the fitness goals and initial examination findings of each participant. Program sessions are held once a week for one hour at a local senior wellness center located in Utica, NY. Facility membership requirements include a small annual membership fee and stipulate that members must be 55 years of age or older. The STEPS participants are recruited primarily by word of mouth. The aim of the STEPS program is to provide an accessible fitness service to improve the health of the Utica community while also supplementing the clinical experiences of students enrolled in the DPT program at Utica College. The program gives students an opportunity to practice clinical skills and reasoning on a weekly basis, and establishes a mentorship component between students. Second-year students are enrolled in a clinical education course for both the Fall (DPT 689) and Spring semesters (DPT 699). Examination and interventions are documented on the WebPT electronic medical record system. Participant reassessments are conducted twice, halfway through the semester and again at the end of the program. PURPOSE OF STUDY Clinics and health programs facilitated by students allow clinical experiences to be interwoven throughout the curriculum and provide students with the opportunity to learn and serve in their community. Research regarding these programs has primarily centered around pro-bono clinics run by medical students, and has been limited to the impact these programs have upon learning. No research has been conducted regarding how a local senior wellness program, such as the STEPS program, impacts senior fitness and DPT student engagement. This study will assess the effect that the STEPS program has upon the health of local seniors, while also qualitatively investigating the impact that the program has had upon the lives of local seniors and students. In order to answer these research questions, a retrospective chart review will be conducted to evaluate the functional outcomes of participating seniors. Additionally, qualitative focus groups will be convened to reflect upon the impact that the STEPS program has had upon the seniors and students.
The proposed study will assess the drug interaction potential between oral cannabidiol (Epidiolex®) and the carboxylesterase 1 (CES1) substrate methylphenidate (Ritalin®) in 12 healthy research subjects
This exploratory, randomized, double-blind, placebo-controlled study aims to explore the effect of novel glycans on nitrogen metabolism in the gut in healthy subjects using a stable isotope.
The goal of this study is to identify reliable markers of LRRK2 activity in human CSF.
This is a phase 1, multi-center, randomized, double-blind, placebo-controlled study in adult participants with peanut allergy. Participants will be randomized in a 3:1 ratio to receive either an escalating dose of INT301 or placebo. The treatment group will be blinded to the investigator, participants, and the Intrommune study team.
The purpose of this research is to evaluate if a hybrid semi-supervised remote exercise training program can reduce symptoms and improve quality of life and physical fitness in individuals with postural orthostatic tachycardia syndrome (POTS) and determine if this program is more effective than current standard of care.
Prospective, randomized, double-blind, placebo controlled, cross-over proof of concept study. To determine the pharmacokinetics and tolerability of co-administration of 5-HT3R antagonist ondansetron with a P-glycoprotein inhibitor tariquidar, in patients with neuropathic pain.