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Neuropathic Pain clinical trials

View clinical trials related to Neuropathic Pain.

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NCT ID: NCT03783689 Recruiting - Neuropathic Pain Clinical Trials

The SNAP Trial: SPRINT® Peripheral Nerve Stimulation for the Treatment of Neuropathic Post-Amputation Pain

SNAP
Start date: December 18, 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to determine if pain can be relieved by delivering small amounts of electricity (called "electrical stimulation") to the nerves in an individual's amputated leg.This study will involve the use of a Peripheral Nerve Stimulation (PNS) System that is made by SPR Therapeutics (the sponsor of the study). The PNS System was cleared by the FDA for up to 60 days of use for the management of chronic pain, including extremity (leg) pain.

NCT ID: NCT03783624 Recruiting - Neuropathic Pain Clinical Trials

Measuring the Effects of Complementary Therapies in Chronic Neuropathic Pain

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The objective of the study is to a) assess the presence of a maladaptive stress response, a decreased pain modulation and any cognitive impairment in patients with chronic neuropathic pain in comparison to healthy controls. and b) evaluate the efficacy of a treatment of hypnosis and of an open label placebo on these neuro-cognitive factors and on clinical pain. This will be done through a) a prospective observational comparative study of patients (base line measures) with Healthy Controls (HC) and b) an Open label; randomised, hypnosis vs. open label placebo (OLP) vs. treatment as usual control design; with a second phase of exploratory cross-over.

NCT ID: NCT03777956 Not yet recruiting - Neuropathic Pain Clinical Trials

The Effect of Lacosamide in Peripheral Neuropathic Pain

Start date: January 2019
Phase: Phase 2
Study type: Interventional

The main purpose of this study is to compare the change in pain intensity during treatment with a sodium-channel blocker (lacosamide) in patients with peripheral neuropathic pain with and without the irritable nociceptor phenotype.

NCT ID: NCT03765801 Completed - Pain Clinical Trials

A Clinical Study in Healthy Women Which Aims to Explore the Intestinal Uptake of Two Different Tablets of GRTA9906 Into the Body and the Effect of Food on it

Start date: October 22, 2003
Phase: Phase 1
Study type: Interventional

The aim of this clinical study in healthy women is to explore the intestinal uptake (bioavailability) of two different tablets of GRTA9906 (formulations) into the body and the effect of food on it. The intake of food may considerably influence the bioavailability, either by interaction with the compound itself or, if a prolonged release (PR) formulation is used, with the components of the tablet-matrix. For these reasons, the relative bioavailability and the effect of food on the bioavailability of GRTA9906 given as PR tablets compared to immediate release (IR) capsules will be assessed in this study. During the 4 periods of the study, each participant will receive two 60 mg GRTA9906 PR matrix tablets and two 60 mg GRTA9906 IR capsules under fed conditions (after consumption of a high-fat and high-calorie test meal) and fasting conditions (10 hours before dosing until 4.5 hours after dosing). In each period, the participant will receive the investigational product once.

NCT ID: NCT03740763 Enrolling by invitation - Neuropathic Pain Clinical Trials

Spinal Cord Stimulation and Physiotherapy for Treatment of Neuropathic Pain

SCS-PHYSIO
Start date: May 9, 2018
Phase: N/A
Study type: Interventional

The study evaluates the combined effect of optimized pharmacological treatment, spinal cord stimulation and physiotherapy on pain relief, health-related quality of life and physical function in patients with neuropathic pain. All patients will receive optimized pharmacological treatment before start of spinal cord stimulation treatment. Half of the participants will be randomized to physiotherapy before start of spinal cord stimulation treatment while the other half will start physiotherapy after spinal cord stimulation treatment.

NCT ID: NCT03735017 Enrolling by invitation - Clinical trials for Spinal Cord Injuries

Virtual Reality Walking for Neuropathic Pain in Spinal Cord Injury

Start date: June 16, 2018
Phase: N/A
Study type: Interventional

This study will examine the effectiveness of one of two virtual reality treatments on neuropathic pain in individuals with spinal cord injury.

NCT ID: NCT03716973 Recruiting - Neuropathic Pain Clinical Trials

A Study to Investigate High-density Spinal Cord Stimulation in Virgin-back Patients

Start date: May 9, 2017
Phase: N/A
Study type: Interventional

This study will look into the effectiveness of spinal cord stimulation (SCS) in reducing chronic neuropathic pain in patients who have not had previous spinal surgery. This will be assessed by comparing the Numerical Rating Scale (NRS) questionnaire responses before and after the SCS intervention. We will also investigate the effect of HD frequency parameters on the improvement of quality of life, sleep and any adverse events following the spinal cord stimulation.

NCT ID: NCT03716557 Recruiting - Neuropathic Pain Clinical Trials

A High Frequency Spinal Cord Stimulation PET-CT Scan Study

Start date: February 9, 2018
Phase: N/A
Study type: Interventional

This study aims to investigate the clinical response to Spinal Cord Stimulation frequency parameters: 40Hz, 4000Hz and 10000Hz and explore the brain imaging changes using PET-CT scans. The response to these stimulator settings on health related quality of life will also be measured using validated questionnaires.

NCT ID: NCT03710967 Active, not recruiting - Neuropathic Pain Clinical Trials

Bilateral TMS vs. Unilateral TMS

biTMSvsuniTMS
Start date: May 1, 2018
Phase: N/A
Study type: Interventional

Rationale: In 2016, Henssen et al. discuss that orofacial pain may be conducted in a bilateral fashion, inducing activation of both thalami [1]. For this reason, bilateral stimulation of the motor cortex is thought to induce a stronger analgesic effect compared to unilateral motor cortex stimulation by transcranial magnetic stimulation. Objective: To investigate the superiority of bilateral transcranial magnetic stimulation (TMS) over unilateral TMS of the motor cortex Study design: Double-blind, randomized controlled trial Study population: Patients that suffer from chronic orofacial pain and have not been treated (yet) with any form of neuromodulation. Intervention (if applicable): One group receives bilateral TMS whereas the other group receives unilateral TMS for one month. After one month, the groups switch treatment protocol. Main study parameters/endpoints: Modification in intensity of pain as measured using the VAS, the influence the relief of pain with regard to quality of life and daily activities using the McGill Pain Questionnaire. Nature and extent of the burden and risks associated with participation, benefit and group relatedness: Time investment of patients.

NCT ID: NCT03686774 Not yet recruiting - Neuropathic Pain Clinical Trials

Memantine and Post-mastectomy Neuropathic Pain

CLEMANTINE
Start date: January 1, 2019
Phase: Phase 2
Study type: Interventional

The aim of this study is to evaluate if memantine administered for four weeks starting two weeks before surgery induces a decrease in pain intensity at 3 months post-mastectomy.