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NCT ID: NCT00689559 Completed - Alzheimer's Disease Clinical Trials

Drug Interaction Study Between AZD3480 and Aripiprazole in Healthy Subjects

Start date: March 2008
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate if AZD3480 and warfarin interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.

NCT ID: NCT00689416 Completed - Atherosclerosis Clinical Trials

Effects of Crestor on Inflammation of Atherosclerotic Plaques

Start date: December 2007
Phase: Phase 0
Study type: Interventional

The primary aim of this study is to investigate the effect of 40 mg dose of rosuvastatin on carotid plaque inflammation measured with MRI and PET scanning, to evaluate whether these techniques are promising for future proof of principle studies. A number of patients will receive placebo as a control.

NCT ID: NCT00689208 Completed - Insulin Resistance Clinical Trials

Pharmacological Intervention in Insulin Resistance Targeting Autonomic Nerve Activity

Start date: May 2007
Phase: Phase 0
Study type: Interventional

The present study on pharmacological intervention in autonomic nervous dysregulation(parasympathetic dysfunction,) regarding insulin resistance, is a concept testing in humans tohelp identify potential new pharmacological target sites in the central nervous system.

NCT ID: NCT00689143 Completed - Periodontitis Clinical Trials

A Safety/Tolerability and Pharmakokinetic Study of Sargramostim Administrated in the Gingiva

Start date: August 2008
Phase: Phase 1
Study type: Interventional

This exploratory study is the first study in a clinical program where the overall objective is to develop a novel pharmaceutical therapy comprising local administration of GM-CSF for the treatment of periodontitis. The project hypothesis is based on GM-CSF's antibacterial and putative bone regeneration properties. Periodontitis is the major cause of tooth loss in people over 35 years of age. An effective pharmacological treatment is today lacking and the actual therapy would represent a new treatment option for the large patient group suffering from the disease.

NCT ID: NCT00689104 Completed - Clinical trials for Urinary Bladder, Overactive

Study to Assess the Efficacy and Safety of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder

SCORPIO
Start date: April 28, 2008
Phase: Phase 3
Study type: Interventional

The study is intended to test efficacy, safety and tolerability of two doses of Mirabegron against placebo and compare the efficacy and safety with active comparator in patients with symptoms of overactive bladder.

NCT ID: NCT00689039 Completed - Healthy Clinical Trials

Study of an Extended Release (ER) Tablet, Single and Repeated Dosing

Start date: April 2007
Phase: Phase 1
Study type: Interventional

The purpose is to study the safety and tolerability of increasing doses of AZD1305 and how the medication is metabolised by the body (how it is taken up, distributed, and how it disappears from the body). The study is performed in healthy volunteers.

NCT ID: NCT00688831 Completed - Healthy Clinical Trials

Single Ascending Dose Study (SAD) iv Formulation

2006-006253-27
Start date: January 2008
Phase: Phase 1
Study type: Interventional

The purpose is to study the safety of AZD1305, how AZD1305 is tolerated and how the medication is metabolised by the body (how it is taken up into the body, distributed around the body and disappears from the body

NCT ID: NCT00688779 Completed - Healthy Clinical Trials

Tolerability/Safety of Intranasal AZD8848 in Healthy Male Volunteers and Seasonal Allergic Rhinitis Male Patients Out of Season

SAD
Start date: January 2008
Phase: Phase 1
Study type: Interventional

Investigate safety/tolerability after a single dose intranasal administration of AZD8848 comparator placebo to healthy male volunteers and seasonal allergic rhinitis male patients out of season

NCT ID: NCT00688740 Completed - Breast Cancer Clinical Trials

Docetaxel in Node Positive Adjuvant Breast Cancer

TAX316
Start date: June 1997
Phase: Phase 3
Study type: Interventional

The purpose of this study was to compare disease-free survival after treatment with docetaxel in combination with doxorubicin and cyclophosphamide to 5-fluorouracil in combination with doxorubicin and cyclophosphamide in operable breast cancer patients with positive axillary lymph nodes.

NCT ID: NCT00688688 Completed - Clinical trials for Urinary Bladder, Overactive

Study to Test the Long Term Safety and Efficacy of the Beta-3 Agonist Mirabegron (YM178) in Patients With Symptoms of Overactive Bladder

TAURUS
Start date: April 25, 2008
Phase: Phase 3
Study type: Interventional

The study is intended to test the safety, tolerability, efficacy of two doses of long term once daily (qd) treatment of Mirabegron in patients with symptoms of overactive bladder and secondly to compare these with active comparator.