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NCT ID: NCT00688623 Completed - Carcinoma Clinical Trials

RAMSETE: RAD001 in Advanced and Metastatic Silent Neuro-endocrine Tumors in Europe

RAMSETE/CDE16
Start date: June 24, 2009
Phase: Phase 2
Study type: Interventional

To evaluate the preliminary efficacy and safety of RAD001 as monotherapy for first-line treatment of patients with metastatic papillary carcinoma of the kidney.

NCT ID: NCT00688402 Completed - Clinical trials for Gastroesophageal Reflux Disease

Study to Compare Different Formulations of AZD3355

Start date: April 2008
Phase: Phase 1
Study type: Interventional

The purpose of the study is to compare different formulations of AZD3355 in regard to possible adverse events such as sensations of numbness, tinglings and heat in the skin.

NCT ID: NCT00687570 Completed - Rectal Cancer Clinical Trials

Bowel Preparation Before Rectal Cancer Surgery

Start date: July 2008
Phase: N/A
Study type: Interventional

Traditionally bowel preparation before surgery of rectal cancer could be troublesome for patients especially for patients with kidney and cardio- vascular diseases, where salt and electrolyte balance can be a problem. Cleaning the bowel without complications for the patient is one of the aims for this study. The other aim is to see if patient nutritional status improves with nutritional drinks as a complement to food intake 4-6 weeks before surgery.

NCT ID: NCT00687141 Completed - Alzheimer's Disease Clinical Trials

Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD0328 in Elderly Healthy Subjects

Start date: November 2007
Phase: Phase 1
Study type: Interventional

The primary purpose of this study is to investigate the safety and tolerability of AZD0328 following once-daily dosing for 13 days in elderly healthy volunteers and to define maximum tolerated dose.

NCT ID: NCT00686504 Completed - Healthy Clinical Trials

Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066

PET
Start date: April 2008
Phase: Phase 1
Study type: Interventional

The study is carried out in order to determine the relationship between AZD2066 exposure and mGluR5 receptor occupancy in the brain and to demonstrate that AZD2066 can displace [11C]AZ12713580 from mGluR5 binding-sites in the Central Nervous System

NCT ID: NCT00686413 Completed - Healthy Clinical Trials

Positron Emission Tomography Study Using 2-[18F]-F-A85380 to Determine α4β2 Neuronal Nicotinic Receptor Occupancy of AZD3480 After Oral Administration to Healthy Male Subjects

PET
Start date: January 2008
Phase: Phase 1
Study type: Interventional

The study is being performed in order to learn more about AZD3480 (potential as treatment for patients with Alzheimer's Disease) and to investigate how much of AZD3480 is bound to the nicotinic receptors in the brain at different concentrations of AZD3480 in blood, as well as to investigate the period of time for this binding.

NCT ID: NCT00684502 Completed - Pain Clinical Trials

Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD2066 in Young and Elderly Healthy Subjects

Start date: January 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and tolerability of AZD2066 using multiple escalating dose panels. There will be separate panels for young healthy volunteers and elderly healthy volunteers. Each panel will contain 10 volunteers who will randomly receive AZD2066 or placebo. One panel will be run at a time with a fixed dose given. After the completion of each panel, a Safety Review Committee will decide if the study can proceed to the next dose panel.

NCT ID: NCT00684190 Completed - Clinical trials for Gastroesophageal Reflux Disease

Drug Interaction Study Between AZD3355 and Nexium

Start date: March 2008
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate if AZD3355 and Nexium interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.

NCT ID: NCT00683865 Completed - Clinical trials for Pelvic Inflammatory Disease

Uncomplicated Pelvic Inflammatory Disease. Treatment With Moxifloxacin.

MAIDEN
Start date: April 2003
Phase: Phase 3
Study type: Interventional

Comparison of various antibiotics in treatment of uncomplicated pelvic inflammatory disease

NCT ID: NCT00683657 Completed - Type 2 Diabetes Clinical Trials

Safety and Efficacy Study of Subjects That Are Taking Saxagliptin Added Onto Metformin XR Compared to Subjects Taking Metformin XR Alone

Start date: July 2008
Phase: Phase 3
Study type: Interventional

This protocol will compare 24 hour glucose control for subject taking saxagliptin and metformin extended release (XR) versus metformin XR alone