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NCT ID: NCT03804580 Recruiting - Lung Cancer Clinical Trials

First-line Treatment With Osimertinib in EGFR-mutated Non-small Cell Lung Cancer, Coupled to Extensive Translational Studies

Start date: December 1, 2018
Phase: Phase 2
Study type: Interventional

Phase II, single-arm study to assess the safety and efficacy of osimertinib (80 mg, orally, once daily) as first-line therapy in patients with EGFR mutation-positive, locally advanced or metastatic non-small cell lung cancer (NSCLC) who have not previously treated with an epidermal growth factor tyrosine kinase inhibitor agent.

NCT ID: NCT03800823 Recruiting - Obesity Clinical Trials

Overweight and Obesity in Preschoolers

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

Obesity interventions in early childhood are recommended as they have been proven to be more effective than interventions later in life. The overall aim of this study is to assess the effectiveness, feasibility, and acceptance of an overweight and obesity intervention in socially disadvantaged families. Participants will be families with children aged 2-6 years (n = 300) with overweight or obesity and will be recruited from three sites: Stockholm, Sweden (n = 100); Timisoara, Romania (n = 100); and Mallorca, Spain (n = 100).

NCT ID: NCT03799939 Not yet recruiting - Clinical trials for Rectal Adenocarcinoma

Chimney Trial of Parastomal Hernia Prevention

Start date: January 2019
Phase: N/A
Study type: Interventional

Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.

NCT ID: NCT03798223 Enrolling by invitation - Ocular Hypertension Clinical Trials

Optimal Treatment Protocol for Selective Laser Trabeculoplasty

Start date: January 10, 2019
Phase: N/A
Study type: Interventional

A randomized controlled trial to evaluate which treatment protocol in selective laser trabeculoplasty that is most optimal in terms of efficacy and safety.

NCT ID: NCT03798210 Recruiting - Clinical trials for Ulcerative Colitis Flare

Lactobacillus Reuteri ATCC PTA 4659 in Ulcerative Colitis

Start date: January 1, 2017
Phase: Phase 2
Study type: Interventional

Explorative investigation to study the effect of the endogenous bacterium Lactobacillus reuteri ATCC PTA 4659 as a nutrient additive against relapse in ulcerative colitis. Forty patients will be studied with a randomized parallel design over one year. Patients with established treatment against relapse of ulcerative colitis with mesalazine ≤4 grams will be requested to participate in the study, allocated to 20 patients with placebo and 20 with active treatment L. reuteri as an "add-on". Inklusion: 18-80 years of age, ≥1 relapse with bleeding during previous 12 months with a disease activity Mayo Clinical Score ≤2, treatment with mesalazine ≤4,0 g daily. Exklusion: >80 years of age, no registered bleeding during recent 12 months, on-going steroid treatment, immunosuppressives, biologics or adhesion inhibitors, antibiotics or other clinical trial. behandling med probiotika. Disease monitoring will be done with: Time to disease relapse with macroscopic bleeding and Mayo score ≥5, blood chemistry and CRP, lipopolysaccharides and gut permeability, fecal calprotectin, and short health scale at 4 weeks, 26 weeks and 52 weeks.

NCT ID: NCT03797833 Recruiting - Clinical trials for Breech Presentation; Before Labor

Spinal Anesthesia for External Cephalic Version

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

This study evaluates the potential benefits of spinal anaesthesia for nulliparous mothers scheduled for external version of babies in breech position.

NCT ID: NCT03793946 Not yet recruiting - Quality Improvement Clinical Trials

A Digital Antimicrobial Stewardship Smartphone Application to Combat AMR: the AB-assistant

Start date: September 2019
Phase: N/A
Study type: Interventional

Optimal prescribing of antimicrobials is becoming increasingly challenging because of the growing complexity of guidelines and constantly changing distribution of infectious pathogens. Prescribing antimicrobials appropriately according to local guidelines optimizes therapy for the individual patient and reduces the emergence of resistance. By adapting and evaluating a smartphone based app containing local guidelines we aim to study appropriate prescribing of antimicrobials by physicians in three hospitals (Netherlands, Sweden and Switzerland).

NCT ID: NCT03793114 Recruiting - Clinical trials for Primary Adrenal Insufficiency

Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease

Start date: September 26, 2018
Phase: N/A
Study type: Interventional

In autoimmune adrenal insufficiency, or Addison's disease (AD), the immune system attacks the adrenal cortex. As a result, the adrenal cells producing hormones such as cortisol and aldosterone are destroyed, leaving the body with insufficient levels to meet its needs. The common perception is that upon diagnosis of Addison's disease, basically all adrenal hormone production has ceased. There have, however, been found a few individuals who preserve some residual secretion of cortisol even years after diagnosis. The objectives of this study is to find out how common it is, and to explore if residual function have impact on patient outcome. That is, do patients with and without residual function differ when it comes to quality of life, working ability, medication dosages, and risk of adrenal crisis?

NCT ID: NCT03787810 Recruiting - Clinical trials for Acute Coronary Syndrome

Left Ventricular Dysfunction in Critically Ill Patients

Start date: August 20, 2018
Study type: Observational

Left ventricular dysfunction is common in the critically ill. The aim of this study is to assess the incidence and prognosis of left ventricular dysfunction in critically ill patients.

NCT ID: NCT03785236 Recruiting - Clinical trials for Type 1 Diabetes Mellitus

Visualizing Beta Cells After Islet Transplantation

Start date: June 6, 2016
Study type: Observational

In patients with type 1 diabetes (T1D) that have undergone islet of Langerhans transplantation or are on the waiting list for transplantation, Ga-68-exendin PET imaging is performed to study the visualization of transplanted islet grafts in patients.