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NCT ID: NCT03466905 Recruiting - Clinical trials for Emergency Medical Service

Does Assessment of Ambulance Medical Service Leads to Reduced Number of Transports to the Emergency Room?

Start date: November 7, 2016
Phase: N/A
Study type: Interventional

There is a need to reduce the number of ambulance transports to the Emergency Room to the patients who are not in need of urgent medical care. There are currently no studies and the aim of the study is to investigate if the ambulance transports to the Emergency Room can be reduced by a dialogue between a Registered Nurse in ambulance and a Medical Doctor in the Primary Care (called "Ambulant assessment"). In this connection there is also a need to follow up patients that not have been transported to the Emergency Room, secondary ambulance transport, relapse within 48 hours, type of examination and treatment and mortality.

NCT ID: NCT03466593 Recruiting - Pancreas Cancer Clinical Trials

Effects of Prehabilitation and Early Mobilization for Patients Undergoing Pancreas Surgery.

Start date: December 18, 2017
Phase: N/A
Study type: Interventional

Open upper gastrointestinal surgery includes surgery in the upper abdomen such as ventricular, duodenal, pancreatic and biliary tract surgery. After upper abdominal surgery there is a risk of gastrointestinal and cardiopulmonary complications. There is currently insufficient knowledge about the effect of prehabilitation and extra early postoperative mobilization in upper pancreatic surgery. This study's aim is to evaluate the effect of prehabilitation and extra early mobilization. The study includes two substudies: 1. A prospective cohort of 75 patients undergoing pancreatic surgery after a prehabilitation program will be compared to 75 historical controls. Primary outcome is postoperative complications. 2. A randomized controlled trial based on 72 patients undergoing pancreatic studying the effect of extra early rehabilitation. The intervention group will be mobilized to bedside, standing or sitting in armchair <6 hours after surgery, ie 3-4 hours after arrival at the Postoperative Department (PIVA). The control group will be mobilized according to routine i.e. the morning after surgery. Primary outcome is PaO2.

NCT ID: NCT03466281 Completed - Patient Education Clinical Trials

Patient Education for Patients With Irritable Bowel Syndrome (IBS)

Start date: August 1, 2016
Phase: N/A
Study type: Interventional

In this randomized controlled study in patients with irritable bowel syndrome (IBS) the investigators plan to compare the effects of a structured patient group education (IBS School) with structured education provided via the internet. The effects of the interventions on GI and psychological symptom severity, knowledge and quality of life will be assessed with validated questionnaires at baseline, immediately after the intervention and 3 and 6 months after the intervention.

NCT ID: NCT03465384 Recruiting - Clinical trials for Attention Deficit Hyperactivity Disorder

Randomized Controlled Trial of Comet Via the Internet or in Group Format.

Start date: March 2018
Phase: N/A
Study type: Interventional

The Comet-program is a Swedish parent training program developed to target externalizing behaviors in children between 3-11 years. The program is normally delivered in group format in primary and specialized care and has already been evaluated in several studies. The internet-based version of the program has also been evaluated separately, but in this study the two formats will be directly compared in a randomized non-inferiority study. Parent ratings, child ratings as well as blinded clinical assessments will be conducted before the interventions, after the interventions (2-3 month after start of intervention), and at follow-up (12 mont after first assessment). The primary research question is: Will the internet-based format of Comet be at least as effective as the group format in reducing externalizing behaviors? Secondary research questions concern possible differential effects of the two formats on cost-effectiveness, parenting behaviors, parent mental health, applicability and consumer satisfaction, and the children's quality of life.

NCT ID: NCT03464045 Active, not recruiting - Clinical trials for Diabetes Mellitus, Type 2

Empa PASS on Urinary Tract Malignancies

Start date: November 16, 2016
Phase: N/A
Study type: Observational

The aim of the study is to assess the risk of urinary tract malignancies in patients initiating empagliflozin (free or fixed dose combination) compared to patients initiating other sodium glucose co-transporter-2 (SGLT-2) inhibitors and to patients initiating a dipeptidyl peptidase-4 (DPP-4) inhibitor (2 separate comparison groups).

NCT ID: NCT03463525 Not yet recruiting - Clinical trials for Non-small Cell Lung Cancer

Open-label PET Study to Determine Brain Exposure With [11C]Osimertinib in Patients With EGFRm NSCLC and Brain Metastases

Start date: September 19, 2018
Phase: Phase 1
Study type: Interventional

This is an open-label, single centre, Phase I study to determine the brain exposure of [11C]osimertinib in patients with EGFRm NSCLC with brain metastases.

NCT ID: NCT03462719 Not yet recruiting - Clinical trials for Leukemia, Lymphocytic, Chronic, B-Cell

A Study of the Combination of Ibrutinib Plus Venetoclax Versus Chlorambucil Plus Obinutuzumab for the First-line Treatment of Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Start date: April 16, 2018
Phase: Phase 3
Study type: Interventional

The purpose of this study is to assess progression‑free survival (PFS) from treatment with ibrutinib plus venetoclax (I+VEN) compared with obinutuzumab plus chlorambucil (G-Clb) as assessed by an Independent Review Committee (IRC).

NCT ID: NCT03461835 Not yet recruiting - Clinical trials for Pregnancy, High Risk

Management of Pregnancies of Unknown Location (PUL)

Start date: March 30, 2018
Phase: N/A
Study type: Interventional

In a randomized multicenter trial we want to compare the ability of two hCG-based models in correctly classifying EPs as high risk among PULs and correctly classifying IUPs and failed PULs as low risk after two hCG measurements. After the classification of PULs into high or low risk of EP, the clinical management will be the same within each risk group (high and low) regardless of randomization group (which model classified the patients). The clinical management will be according to the management protocol published in a NICE guideline.

NCT ID: NCT03461640 Not yet recruiting - Labor Pain Clinical Trials

Community Based Doulas for Migrant Women in Labour and Birth in Sweden - a Randomised Controlled Trial

Start date: March 10, 2018
Phase: N/A
Study type: Interventional

One initiative to address communication problems between migrant women not fluent in Swedish and caregivers throughout childbirth is to provide language assistance, cultural interpretation and labour support to the woman through Community Based Doulas (CBDs). CBDs are bilingual women from migrant communities trained by midwives to provide cultural, language and labour support to migrant women throughout their labour and birth. The study will evaluate the effectiveness of community-based doula support for improving the intrapartum care experiences and postnatal wellbeing of Somali-, Tigrinya -, Arabic- and Russian-speaking migrant women giving birth in Stockholm, Sweden. The randomisation ratio will be 1:1; CBD support in addition to standard intrapartum care or standard intrapartum care. Women allocated to receive CBD support in addition to standard intrapartum care (intervention group), will be contacted by a Somali, Arabic-, Russian- or Tigrinya-speaking CBD as appropriate, and arrangements will be made for the doula and the women to meet twice prior to the birth to get to know each other and discuss the woman's wishes regarding support in labour and what the CBD can offer. Each woman will then contact her CBD when she goes into labour and the CBD will attend hospital with her and stay with her throughout labour and birth, in addition to any other support people she may have, such as her partner. Women allocated to the comparison arm of the trial will receive standard intrapartum care as provided at their chosen hospital of birth. The hypothesis is that women randomised to receive CBD support in labour will rate their care for labour and birth more highly and have better emotional wellbeing (lower mean scores on the Edinburgh Postnatal Depression Scale) two months after birth than women allocated to standard care.

NCT ID: NCT03461341 Active, not recruiting - Esophageal Cancer Clinical Trials

European iNvestigation of SUrveillance After Resection for Esophageal Cancer

Start date: June 1, 2009
Phase: N/A
Study type: Observational

The ENSURE study will comprise two phases. Phase 1: European multicenter survey of surveillance protocols after esophageal cancer surgery ENSURE questionnaire will be circulated to representatives from participating European countries. Phase 2: European multicenter retrospective observational study of the impact of postoperative surveillance protocols on oncologic outcome and HR-QL Phase 2 will constitute a retrospective observational study of patients undergoing treatment with curative intent for esophageal cancer at participating Centers from June 2009 to June 2015.