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NCT ID: NCT03374787 Enrolling by invitation - Clinical trials for Conductive Hearing Loss

Evaluation of Sound Processor for a Transcutaneous System

Start date: November 15, 2017
Phase: N/A
Study type: Interventional

A single center study evaluating the performance of an externally worn sound processor for a transcutaneous bone anchored hearing system using audiological outcomes measures such as aided thresholds and speech intelligibility and self evaluation questionnaires.

NCT ID: NCT03373448 Not yet recruiting - Peri-Implantitis Clinical Trials

Treatment of Mild to Moderate Peri-implantitis Using an Oscillating Chitosan Device

Start date: January 2018
Phase: N/A
Study type: Interventional

By each clinician participating in the study; 40 patients (20+20) diagnosed with mild to moderate peri-implantitis, defined as 2-4 mm peri-implant bone loss, will be randomized to either test treatment with Labrida BioClean® or control treatment with titanium curettes. In total 240 patients (120 test and 120 controls) treated by 6 clinicians at 6 centers will be included in the study.

NCT ID: NCT03370887 Not yet recruiting - Heart Failure Clinical Trials

AZD8601 Study in CABG Patients

Start date: December 20, 2017
Phase: Phase 2
Study type: Interventional

This is a randomized, double-blind, placebo-controlled, sequential design, multicentre study in patients with moderately impaired systolic function undergoing CABG surgery. Twenty four (24) patients scheduled for elective bypass surgery will be randomized (up to approximately 33 patients if replacements are needed). The objective is to investigate safety and tolerability of AZD8601 following epicardial injection in patients undergoing Coronary Artery Bypass Grafting (CABG) surgery with moderately impaired systolic function. At Visit 3 patients will receive either AZD8601 or placebo as epicardial injections and will then be followed up at 14 days (telephone visit) and 1, 3 and 6 months (on-site) post-surgery.

NCT ID: NCT03370679 Recruiting - Clinical trials for Premature Ventricular Contraction

The Prognostic Significance of Premature Ventricular Complexes in Patients Without Structural Heart Disease

PULSE
Start date: September 2013
Phase: N/A
Study type: Observational

With this project the investigators aim to investigate whether premature ventricular complexes (PVC) have a prognostic significance in persons without structural heart disease. Further the investigators look at the possible connection between PVC-morphology and clinical outcome and investigate whether advanced cardiac imaging-methods may identify subtle signs of heart disease in PVC-patients with normal findings at echocardiography.

NCT ID: NCT03368794 Recruiting - Clinical trials for Substance Use Disorders

Naloxone to TReatment Entry in the Emergency Setting

N-TREE
Start date: September 15, 2017
Phase: N/A
Study type: Interventional

The study tests a structured referral process for opioid overdose survivors, from pre-hospital emergency care to long-term treatment of the individual's substance use-related disorder.

NCT ID: NCT03368521 Recruiting - Low Back Pain Clinical Trials

The Benefit of Structured Triage of Patients in the Primary Health Care Seeking Care for Low Back Pain

Start date: November 1, 2017
Phase: N/A
Study type: Interventional

This study aims to investigate if a low back pain screening tool is helpful for the caregivers to direct the rehabilitation in a more efficient way, at an earlier stage. Primary Health care centers in the municipality of Halmstad, Sweden will be enrolled to participate in the study as either "Control" or "intervention". The primary Health care centers who are enrolled taking part in the intervention, will use the provided screening tool when taking care of patients seeking care for low back pain. Scorings from the screening tool will "label" the patients as one of Three pre-defined risk levels. The caregiver will then use the provided risk level when deciding how to proceed the rehabilitation. Based on the risk level identified, the patient is directed to one of three levels of treatments - including simple advice; physiotherapy; or multimodal rehabilitation. The screening tool is used as a complement to the examination, allowing the physiotherapist /GP to decide how to proceed with rehabilitation using the back screening tool, together with Clinical examinations. The Control Group consists of patients recruited when seeking care for back pain at a Primary Health Care service who has been randomly selected as "Control". The care givers at the Control primary Health care will conduct as usual, not using the back pain screening tool in their Clinical examinations.

NCT ID: NCT03368235 Not yet recruiting - Clinical trials for Rheumatoid Arthritis

Early Phase Study to Assess Efficacy and Safety of AZD9567 Versus Prednisolone in Patients With Rheumatoid Arthritis

Start date: December 19, 2017
Phase: Phase 2
Study type: Interventional

This is a phase 2a study to be run in 2-3 countries in EU involving 5-6 sites. It will enroll approximately 80 patients to ensure 40 randomized with active rheumatiod arthritis. The treatment period is 2 weeks and total study duration per patient is approximately 1 month. The study drugs are AZD9567 40 mg (an oral SGRM) and the comparator is prednisolone 20mg. The primary endpoint is DAS28 including evaluation of 28 joints and C-reactive protein. Safety parameters will also be evaluated and a biomarker program is included for future research.

NCT ID: NCT03364868 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 1

GPPAD-POInT (Global Platform of Autoimmune Diabetes - Primary Oral Insulin Trial)

Start date: January 2018
Phase: Phase 2
Study type: Interventional

The GPPAD-POInT Study is designed as a randomized, placebo-controlled, double blind, multicentre, multinational primary prevention phase IIb study aiming to induce immune tolerance to beta-cell autoantigens through regular exposure to oral insulin for a period of 29 to 32 months. The hypothesis is that regular exposure to oral insulin throughout the period in life where beta-cell autoimmunity usually initiates will tolerize against insulin and train the body's immune system to recognize the treatment product without reacting adversely to it in a manner seen in children who develop T1D. This immune tolerance induction therapy would reduce the likelihood of beta-cell autoimmunity. The study objective is to determine whether daily administration of oral insulin from age 4 months - 7 months until age 3.00 years to children with elevated genetic risk for type 1 diabetes reduces the cumulative incidence of beta-cell autoantibodies and diabetes in childhood.

NCT ID: NCT03362983 Recruiting - Clinical trials for Cardiovascular Diseases

Integrated, Multidisciplinary, Person-centered Care for Patients With Complex Comorbidities: Heart, Kidney and Diabetes

CareHND
Start date: January 1, 2016
Phase: N/A
Study type: Interventional

Patient with complex comorbidities present a growing challenge for health-care providers, that the current system is poorly designed to handle. Concomitant cardiovascular disease, renal dysfunction and diabetes represent almost half of all patients attending cardiac, kidney and diabetes clinics. Patients with all three of these will be randomized to standard care or to a combined, integrated, person-centered, intensified chronic disease management.

NCT ID: NCT03362879 Not yet recruiting - Clinical trials for Parkinson's Disease (PD)

COmedication Study Assessing Mono- and cOmbination Therapy With Levodopa-carbidopa inteStinal Gel

Start date: December 14, 2017
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate treatment of advanced Parkinson's Disease (PD) patients on levodopa-carbidopa intestinal gel (LCIG) monotherapy in a routine clinical setting.