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NCT ID: NCT03587376 Recruiting - Alzheimer Disease Clinical Trials

Characterization of T-Cell Response in Participants Previously Treated With JNJ-54861911 (Atabecestat)

Start date: May 30, 2018
Phase: Early Phase 1
Study type: Interventional

The purpose of this study is to determine T-cell mediated inflammatory immune response in some participants previously exposed to atabecestat.

NCT ID: NCT03586856 Not yet recruiting - Infant,Premature Clinical Trials

Comparison of Leakage With Nasal Prongs and Nasal Mask Interface in Newborns Receiving CPAP Treatment

Start date: July 25, 2018
Phase: N/A
Study type: Interventional

The study is a two-armed randomized cross-over comparison of leakage with nasal prongs and nasal mask interface in newborn infants treated with CPAP, born after 28 weeks of gestational age. For infants with an interface leakage, the trial also includes an observational part evaluating simple measures to reduce leakage. The study will be carried out in the Karolinska University Hospital Stockholm and in the Östersund Hospital.

NCT ID: NCT03586011 Active, not recruiting - Physical Activity Clinical Trials

Which Patients Benefit From Physical Activity on Prescription? A Predictor Analysis of Factors for Increased Physical Activity.

Start date: January 1, 2010
Study type: Observational [Patient Registry]

The aim of this study is to explore possible predicting factors associated with physical activity (PA) level change in a 6-month period of physical activity on prescription (PAP) treatment. This is done in order to highlight potential predictors important for increased PA-level and to identify which primary care patients who may benefit from the PAP-intervention. Four hundred forty four patients are included in the study, 27-85 years, physically inactive, having at least one component of the metabolic syndrome (MetS) present and receiving PAP-treatment. Possible predicting factors of PA change at baseline and PA-level at 6-month follow-up are analyzed.

NCT ID: NCT03581019 Enrolling by invitation - Transplantation Clinical Trials

Uterus Transplantation From Deceased Donor - Gothenburg III

Start date: June 17, 2018
Phase: N/A
Study type: Interventional

Deceased donor uterus transplantation will be offered to patients that have either been excluded from Gothenburg II because of donor criteria or because of early graft failure in Gothenburg I and II

NCT ID: NCT03579498 Recruiting - Cardiac Arrest Clinical Trials

Brain Function After Cardiac Arrest

Start date: February 26, 2018
Study type: Observational

The aim of this longitudinal study is to determine whether brain function is affected after a cardiac arrest. The primary question is whether cognitive function is affected after cardiac arrest and whether it changes over time (during the first year after the event), compared with a healthy control group. Brain function during cognitive tasks and emotion processing will also be studied using functional MRI (fMRI). Another aim is to study whether clinical outcomes such as PTSD, anxiety and depression can be correlated with cognitive function and whether health- related quality of life is affected after a cardiac arrest. The results from the cardiac arrest patient group will be compared with a healthy control group.

NCT ID: NCT03579342 Recruiting - Quality of Life Clinical Trials

App-technology to Improve Healthy Lifestyle Behaviors Among Working Adults

Start date: April 16, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate if modern technology such as smartphone applications can be used to facilitate lifestyle changes and thereby improve health-related quality of life in gainfully employed persons in the general population in Stockholm, Sweden. The hypothesis is that at follow-up, the intervention group that use the new application will have improved health-related quality of life and other lifestyle habits including diet, physical activity and sleep, as well as biomarkers, compared to a control group.

NCT ID: NCT03576846 Not yet recruiting - Neck Pain Clinical Trials

Spinal Manipulative Therapy, Heart Rate Variability and Conditioned Pain Modulation

Start date: September 2018
Phase: N/A
Study type: Interventional

This randomized, single-blinded study will investigate the effects of Spinal Manipulative Therapy on Heart Rate Variability and Pain Sensitivity in a population of patients with recurrent and persistent neck pain. Alongside, the study will also develop a clinical test for Conditioned Pain Modulation and investigate its predictive properties.

NCT ID: NCT03576443 Recruiting - Clinical trials for Diffuse Large B Cell Lymphoma

Trial of Idelalisib in Patients With Relapsed Diffuse Large B-cell Lymphoma

Start date: July 7, 2017
Phase: Phase 2
Study type: Interventional

Based on the high response rate in heavily pretreated patients with indolent B-cell lymphomas, among which it is likely that many have undetected transformed disease, the investigators hypothesize that idelalisib may also be active in relapsed DLBCL, particularly of the GCB subtype. Possibly, the efficacy may be related to the presence of specific mutations within the B-cell receptor pathway.

NCT ID: NCT03576261 Recruiting - Heart Failure Clinical Trials

Heart Failure and Hemodynamic Stability During Anesthesia Induction

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

The study aim is to investigate whether preoperative heart failure has impact on hemodynamic stability during anesthesia induction by target controlled infusion of anesthesia (TCI) in non-cardiac, non-morbidly obese surgery.

NCT ID: NCT03575104 Recruiting - Insomnia Disorder Clinical Trials

Study to Assess the Efficacy and Safety of ACT-541468 in Adult and Elderly Subjects Suffering From Difficulties to Sleep

Start date: May 29, 2018
Phase: Phase 3
Study type: Interventional

The main purpose of this Phase 3 study is to evaluate the efficacy of 10 mg and 25 mg ACT-541468 on objective sleep parameters in subjects with insomnia disorder.