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Periodontitis clinical trials

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NCT ID: NCT03677297 Completed - Adult Periodontitis Clinical Trials

"Efficacy Of 1.2% Rosuvastatin Gel In The Management Of Infrabony Defects"

Start date: January 28, 2016
Phase: Phase 4
Study type: Interventional

Study aims to evaluate clinical and radiographic effectiveness of 1.2% Rosuvastatin gel in the treatment of Infrabony defects in chronic periodontitis patients.

NCT ID: NCT03671408 Completed - Periodontitis Clinical Trials

Levels of High-Sensitivity C-Reactive Protein in Heart Transplant Patients

Start date: April 20, 2016
Study type: Observational [Patient Registry]

Objectives: The outcomes of heart transplantation are very favorable but inflammation still plays a critical role in deterioration of chronic transplants. Periodontal diseases are not only limited to supporting structures of the teeth, they also cause systemic inflammation. Based on the importance of inflammation in heart transplant recipients and the association between periodontal disease and systemic inflammation, this study explored whether periodontitis may be a modifier of serum high-sensitivity C-reactive protein (HsCRP) in heart transplant patients.

NCT ID: NCT03670979 Completed - Periodontitis Clinical Trials

Periodontal Osseous Wall Piezosplitting and EDTA Root Surface Etching

Start date: January 5, 2016
Phase: N/A
Study type: Interventional

This study was designed to investigate the use of minimally invasive Piezo knife to harvest vascularized interceptal bone pedicle in treating intrabony defects.

NCT ID: NCT03660163 Active, not recruiting - Clinical trials for Periapical Periodontitis

Assessment of the Outcome of Endodontic Treatment Using Cone Beam Computed Tomography.

Start date: November 1, 2016
Study type: Observational

The aim of the study is to assess the correlation between pre-obturation bacterial detection using fluorescence amplification and outcome of endodontic treatments. Thus, enabling a suitable detection threshold to predict the likelihood of treatment failure. This has the potential to be used a bench side tool in general dental practice to act as a surrogate endpoint for clinicians performing root canal treatment.

NCT ID: NCT03656484 Not yet recruiting - Clinical trials for Chronic Periodontitis

New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin

Start date: December 2018
Phase: Phase 2
Study type: Interventional

The aim of the present study is to determine whether the association of Melatonin and Hyaluronic Acid to the antimicrobial TM paste (3% Tetracyclin and 3% Metronidazole) for periodontal maintenance therapy can improve the attachment level (AL) and alveolar bone support for moderate chronic periodontitis.

NCT ID: NCT03652558 Completed - Periodontitis Clinical Trials

Effects of Ozone Therapy as an Adjunct to Periodontal Treatment

Start date: January 10, 2017
Phase: N/A
Study type: Interventional

This randomized, placebo controlled, split-mouth clinical study trial evaluates the effects of Ozone therapy on clinical and biochemical parameters. Total of 20 participants completed the study . Periodontal parameters were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1β (IL-1β) and high sensitivity C-reactive protein (Hs-CRP) were evaluated.

NCT ID: NCT03644901 Recruiting - Clinical trials for Chronic Periodontitis

Assessment of Response to the Conventional Periodontal Treatment Based on the Blood Group Phenotypes.

Start date: January 15, 2018
Study type: Observational

The aim of this study is to find out if one blood group phenotype is more responsive than the others to the nonsurgical periodontal treatment.

NCT ID: NCT03642353 Completed - Clinical trials for Generalized Aggressive Periodontitis

Triclosan as Adjunctive Therapy in the Plaque Control in Children From Generalized Aggressive Periodontitis Families.

Start date: January 30, 2017
Phase: Phase 4
Study type: Interventional

Generalized aggressive periodontitis (GAP) is an inflammatory disease that causes the severe and rapid destruction of periodontal tissue. A relatively constant microbiological pattern, an altered inflammatory condition and familial aggregation of cases were described as important characteristics of this disease. In this vein, studies evaluating children of GAP patients were made and identified early microbiological and inflammatory alterations in this population, suggesting that these factors could favor the disease development. Thus, the aim of this project is to evaluate if the use of toothpaste with Triclosan could have a beneficial effect in control the microbiota and the inflammatory condition in children from parents with GAP, comparing them to children of periodontally healthy parents. 20 children (6-12 years old) from GAP parents and 20 children (6-12 years old) from periodontally healthy parents will be selected and will participate in a cross-over placebo study. All children will be included in a 15-day period of control of plaque to standardize the hygiene technique using only the placebo toothpaste. After this period, the children will be divided randomly into 4 groups: G1: Triclosan/health children; G2: Placebo/health children; G3: Triclosan/GAP children; G4: Placebo/GAP children and they will use the specific paste described for each group for 45 days. After this period, all children will repeat the 15 days interval, using only the placebo toothpaste, to remove the Triclosan effect and to standardize the oral hygiene again. Posteriorly, the crossing of groups will be done and children will be reallocated to change the used toothpaste. Thus, children that were in G1 will be reallocated in G2, children of G2 will be reallocated in G1, children of G3 will be in G4 and children of G4 will be in G3, staying in this new group for more 45 days. The evaluated periods will be baseline, 15 days, 30 days and 45 days while children stay in G1, G2, G3 or G4. In these periods children will be clinically evaluated for the periodontal parameter and sample collection of crevicular gingival fluid (GCF) and subgingival biofilm from incisors and molars will be done. Luminex/MAGpix technology will be used to detect IL-1β, IL-4, IL-6, IL-8, IL-10, IL-17, TNF-α, INF-γ in the GCF. The subgingival biofilm will be used to evaluate the Porphyromonas gingivalis, Tannerella forsythia, Aggregatibacter actinomycetemcomitans levels by real-time PCR.

NCT ID: NCT03639636 Completed - Periodontitis Clinical Trials

is the Sclerostin Marker of Chronic Periodontitis

Start date: June 1, 2017
Phase: N/A
Study type: Interventional

Reviewed literature suggests that sclerostin will inhibit the bone formation and ultimately leads to chronic periodontitis. Estimation of Sclerostin levels in the serum of periodontitis patients before and after intervention could explore the effectiveness of therapy and also give a more detailed insight into its diagnostic and prognostic potential as a biomarker of periodontal disease.

NCT ID: NCT03631693 Enrolling by invitation - Periodontitis Clinical Trials

Imaging Analysis Following Periodontal Surgery

Start date: February 21, 2018
Phase: N/A
Study type: Interventional

This is a single centre, randomised, single-blind, parallel-group clinical trial that aims at evaluating the use of imaging (2D and 3D) in obtaining geometric and thermometric changes of postoperative healing patterns and comorbidities (facial swelling, oedema and inflammation) following two routine surgical procedures performed for the treatment of periodontal (gum) disease.