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Periodontitis clinical trials

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NCT ID: NCT03733379 Recruiting - Periodontitis Clinical Trials

Systemic Probiotics in the Periodontal Treatment

Start date: November 5, 2018
Phase: Phase 3
Study type: Interventional

The aim of this multicenter randomized clinical trial is to evaluate the clinical, microbiological and immunological effects of probiotics as an adjunct to Scaling and Root Planing alone or in combination with Metronidazole and Amoxicillin in the treatment of periodontitis.

NCT ID: NCT03727620 Completed - Clinical trials for Aggressive Periodontitis

Doxycycline in the Treatment of Aggressive Periodontitis

Start date: January 6, 2014
Phase: Phase 1/Phase 2
Study type: Interventional

The aim of the study was to compare the clinical effects of systemic use of doxycycline to amoxicillin plus metronidazole as adjunctive treatment in nonsurgical debridement of aggressive periodontitis (AgP). Twenty four patients with aggressive periodontitis were enrolled in this clinical study. They all received oral hygiene instruction and full-mouth nonsurgical debridement using manual instruments. The test group received as adjunctive antibiotic treatment 200 mg of doxycycline the first day followed by 100 mg per day during 14 days. The control group received 500 of amoxicillin and 250 of metronidazole, three times a day for 7 days.

NCT ID: NCT03727035 Recruiting - Clinical trials for Periodontal Diseases

Quantification of CD163 Inflammatory Biomarker in Chronic Periodontitis and Diabetic Subjects

Start date: February 10, 2018
Study type: Observational

The quantification of CD163 will be analysed in the subgingival plaque samples of generalized chronic periodontitis patients with and without diabetes mellitus. The demographic and the periodontal parameters were assessed and the correlated with the quantification of the CD163. The CD163 gene expression was analyzed with RTPCR and the quantification of CD163 will be done using ELISA.

NCT ID: NCT03726411 Not yet recruiting - Periodontitis Clinical Trials

The Effect of Non-surgical Periodontal Therapy on the Gingival Crevicular Fluid Levels of Prolactin Hormone in Patients With Periodontitis.

Start date: November 2018
Phase: N/A
Study type: Interventional

The present study will be conducted on fifty participants. All participants will receive a full-mouth clinical examination, and the following periodontal parameters will be recorded: Plaque Index (PI). Gingival Index (GI), probing depth (PD), and clinical attachment level (CAL). All of these measurements will be recorded at six sites at baseline for all participants and 3 months after non-surgical periodontal therapy for the study group. GCF samples will be collected from the buccal aspects of teeth that had the highest signs of inflammation and attachment loss for periodontitis group at baseline and 3 months after non-surgical periodontal therapy. As for controls, the samples will be collected from buccal aspect of upper first molar at baseline. The samples will be assayed for prolactin by using an enzyme linked immunosorbent assay kits (Elisa) according to the manufacturer instruction.

NCT ID: NCT03721159 Completed - Coronary Disease Clinical Trials

Quantification of Micro-RNA 146-a in Chronic Periodontitis and Coronary Heart Disease Subjects

Start date: October 1, 2017
Study type: Observational

The expression and quantification of Micro-RNA 146-a, was analyzed in the subgingival plaque samples of generalized chronic periodontitis patients with and without coronary heart disease. The demographic variables and periodontal parameters were assessed and correlated with expression of micro-RNA 146-a. The quantification of levels of micro-RNA 146-a was done using Real time Polymerase chain reaction. ( RT-PCR)

NCT ID: NCT03716154 Completed - Periodontitis Clinical Trials

Clinical Effectiveness of Diode Laser as an Adjunct in the Treatment of Periodontitis

Start date: April 1, 2017
Phase: N/A
Study type: Interventional

a randomized controlled single-blinded study. the hypothesis of this clinical trial is that disjunctive use of diode laser improve the clinical parameters of periodontists , and there are significant difference between the conventional treatment and diode laser as an adjunct

NCT ID: NCT03711942 Completed - Clinical trials for Apical Periodontitis

Comparison of Healing of Apical Periodontitis in Periodontally Diseased and Healthy Patients.

Start date: October 15, 2016
Phase: N/A
Study type: Interventional

Periodontal health may jeopardize the success of endodontic treatment.Intraorifice barrier apart from enhancing probability of success of endodontic treatment may also augment periodontal therapy as intra pulpal infection is known to contribute in worsening of periodontal health by promoting marginal bone loss and pocket formation.This study compared the apical healing in healthy and periodontally compromised teeth and evaluated the effect of intra orifice barrier and base in the healing of apical periodontitis.

NCT ID: NCT03708081 Completed - Pulpitis Clinical Trials

Comparative Evaluation of Different File Systems in Postoperative Pain

Start date: June 1, 2017
Study type: Observational [Patient Registry]

Postoperative pain is a frequent complication associated with root canal treatment. The apical extrusion of irrigant and debris, including bacteria and necrotic tissue, may lead to postoperative pain, periapical inflammation, and flare-ups. The instrumentation technique and the file design may affect the amount of debris extrusion. The aim of this study was to evaluate the influence of instrumentation techniques on the incidence and intensity of postoperative pain after single-visit root canal treatment.

NCT ID: NCT03700788 Enrolling by invitation - Clinical trials for Apical Periodontitis

2% Chlorhexidine (CHX) vs CaOH2 (CH) Calcium Hydroxide Paste as an Intracanal Medicament

Start date: November 1, 2018
Phase: Phase 3
Study type: Interventional

This is a Pilot Phase III single-blind randomized controlled clinical trial in patients, aged 18 years and older, presenting with symptoms of apical periodontitis. The overall goal is to assess whether 2% Chlorhexidine (CHX) is superior to Calcium Hydroxide in reducing interappointment pain.

NCT ID: NCT03692819 Recruiting - Clinical trials for Chronic Periodontitis Complex

Antibiotic and Probiotic Therapies in the Adjuvant Treatment of the Chronic Periodontitis.

Start date: May 2, 2018
Phase: N/A
Study type: Interventional

Currently, with the increase of bacterial resistance to antibiotics associated with its side effects, it is necessary to find other adjuncts to combat the disease that are an alternative to the use of antibiotics. The use of probiotics has been proposed in the literature as an adjunct therapy for the treatment of periodontal diseases, however, few controlled and randomized clinical studies have been performed. The objective of this double-blind randomized controlled trial will be to evaluate the response of clinical and microbiological periodontal parameters to the comparison of two different adjuvant therapies (antibiotic and probiotic) for the treatment of chronic generalized periodontitis.