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NCT ID: NCT00692705 Completed - Alzheimer´s Disease Clinical Trials

Positron Emission Tomography (PET) Study With [11C]AZD2995 and [11C]AZD2184, Candidate PET Ligands for β Amyloid

PET
Start date: January 2008
Phase: Phase 1
Study type: Interventional

The study is carried out in order to investigate if [11C]AZD2995, compared to [11C]AZD2184, is a more suitable PET ligand for in vivo imaging of β amyloid depositions in the human brain. In the study the two PET ligands will be examined in both healthy volunteers and patients with Alzheimer's Disease.

NCT ID: NCT00692536 Completed - Obesity Clinical Trials

Diet Composition - Metabolic Regulation and Long-term Compliance

KNOTA
Start date: September 2007
Phase: N/A
Study type: Interventional

This study will compare a high-protein/low-carbohydrate diet (modified paleolithic diet, MPD) with a diet high in slow carbohydrates (Nordic Nutrition Recommendations, NNR). The diets will be compared with respect effects on weight reduction, metabolic regulation, and long-term compliance to the diet regimes. Seventy-two postmenopausal overweight healthy women have been recruited and will be followed for two years. The following variables will be studied: - Anthropometry - DEXA - OGTT - Liver fat content measured with 1H-MRS - Hepatic 11β-HSD1 activity, measured with cortisone/cortisol conversion test

NCT ID: NCT00692510 Completed - Alzheimer's Disease Clinical Trials

Drug Interaction Study Between AZD3480 and Cytochrome P450

Cocktail
Start date: November 2007
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate if AZD3480 inhibits Cytochrome P450 1A2, 2C19, 3A4, 2C8, 2B6 and UGT1A1 activity.

NCT ID: NCT00690482 Completed - Clinical trials for Moderate to Severe COPD

Study to Assess the Efficacy and Safety of AZD1981 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)

Columbus
Start date: May 2008
Phase: Phase 2
Study type: Interventional

The purpose of this study is to study efficacy and safety of AZD1981 in patients with Chronic Obstructive Pulmonary Disease

NCT ID: NCT00690430 Completed - Clinical trials for Symptomatic Refractory Resistant Carcinoid Disease

Efficacy and Safety of Pasireotide Long Acting Release vs. Octreotide Long Acting Release in Patients With Metastatic Carcinoid Disease

Start date: April 2008
Phase: Phase 3
Study type: Interventional

The purpose of this randomized, multicenter, Phase III study was to compare the efficacy of paseriotide LAR and octreotide LAR in patients whose disease-related symptoms are inadequately controlled by currently available somatostatin analogues.

NCT ID: NCT00690287 Completed - Type 2 Diabetes Clinical Trials

A Study to Evaluate P-Glucose, Safety and Tolerability After Oral Single Dosing of AZD6370 in Type 2 Diabetic Patients

Start date: February 2008
Phase: Phase 1
Study type: Interventional

The purpose of this study is to assess the effect of AZD6370 on blood sugar and to study safety and tolerability in patients with type 2 diabetes.

NCT ID: NCT00689936 Completed - Multiple Myeloma Clinical Trials

Study to Determine Efficacy and Safety of Lenalidomide Plus Low-dose Dexamethasone Versus Melphalan, Prednisone, Thalidomide in Patients With Previously Untreated Multiple Myeloma

FIRST
Start date: August 21, 2008
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the safety and efficacy of Lenalidomide plus low dose dexamethasone to that of the combination of melphalan, prednisone and thalidomide.

NCT ID: NCT00689780 Completed - Low Back Pain Clinical Trials

Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940

Start date: March 2008
Phase: Phase 1
Study type: Interventional

A Phase I, Multi-Centre, Randomised, Double-blind, Placebo-controlled Study to Investigate the Safety, Tolerability and Pharmacokinetics of AZD1940, Including an Interaction Study, After Administration of Oral Multiple Ascending Doses in Adult Subjects with Chronic Low Back Pain

NCT ID: NCT00689663 Completed - Cholecystectomy Clinical Trials

Laparoscopic Cholecystectomy - Fundus First and Harmonic Ace Compared With Conventional Technique

Start date: May 2006
Phase: N/A
Study type: Interventional

Laparoscopic cholecytectomy can be by starting the dissection at the triangle of calots or as a fundus first dissection. Dissection can be with electrocutery or ultrasonic. The optimal technique or the optimal way of dissection has to be established. Patients are at 4 hospitals randomised to the different techniques and the different methods of dissection.

NCT ID: NCT00689637 Completed - Alzheimer's Disease Clinical Trials

Drug Interaction Study Between AZD3480 and Warfarin

DDI
Start date: September 2007
Phase: Phase 1
Study type: Interventional

The purpose of the study is to evaluate if AZD3480 and warfarin interact with each other or not, i.e. show the same or altered plasma concentration profiles when co-administered compared to administered alone.