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NCT ID: NCT06014359 Recruiting - Dexmedetomidine Clinical Trials

Preoperative Nebulized Dexmedetomidine on Hemodynamic Changes in Laparoscopic Bariatric Surgery.

Start date: August 27, 2023
Phase: N/A
Study type: Interventional

This randomized study aims to evaluate the effect of preoperative dexmedetomidine nebulization on blunting hemodynamic response for laryngoscope, intubation and pneumoperitoneum in morbidly obese patients undergoing laparoscopic bariatric surgery.

NCT ID: NCT06013644 Recruiting - Clinical trials for Myofascial Pain Syndrome

Acupuncture, Dry Needle and Botox Injection in Management of Patient With Myofascial Pain Dysfunction Syndrome

Start date: June 3, 2023
Phase: Early Phase 1
Study type: Interventional

Evaluating myofascial pain dysfunction symptoms using acupuncture, dry needle and Botox injection using electromyography and visual Analogue Scale on two time intervals at 2 and 6 months after the intervention

NCT ID: NCT06012643 Recruiting - Alveolar Bone Loss Clinical Trials

Subperiosteal Implants Constructed With Digital Technology

Start date: June 1, 2023
Phase:
Study type: Observational

Atrophied jaw is a condition where there is insufficient bone quantity to place root form implants. Several treatment plans are available for treating atrophied jaws, including subperiosteal implants. Subperiosteal implants were introduced in the last century. Poor clinical results led those implants to be progressively abandoned. Recently, several Authors suggested a revival of subperiosteal implants as an alternative to regenerative procedures.

NCT ID: NCT06010992 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Nitazoxanide as Adjuvant Therapy in Type 2 Diabetes Mellitus

Start date: October 1, 2023
Phase: Phase 2
Study type: Interventional

Diabetes mellitus (DM) is a complex metabolic disorder characterized by hyperglycemia and abnormalities in carbohydrate, fat, and protein metabolism. Despite the advancement in anti-diabetic drug therapy, most patients fail to achieve optimal glycemic control. This highlights the need for more effective strategies to control type 2 diabetes mellitus. Nitazoxanide (NTZ), a broad-spectrum anti-infective drug with activity against various protozoa, helminthes, bacteria, and viruses, was identified as peroxisome proliferative activated receptor gamma (PPARγ) agonist using one dimensional drug profile matching. Additionally, it improved insulin sensitivity in insulin-resistant type 2 diabetic rats. Therefore, this study is designed to evaluate the efficacy of nitazoxanide as adjunctive therapy in patients with type 2 diabetes mellitus.

NCT ID: NCT06010927 Recruiting - Emergence Delirium Clinical Trials

Effect of Ketamine/Midazolam Premedication Versus Pre-extubation Ketofol on Recovery Profile in Pediatrics Undergoing Adenotonsillectomy.

Start date: August 25, 2023
Phase: Phase 4
Study type: Interventional

An optimum recovery profile after AT includes a rapid, smooth awakening without emergence agitation (EA), stable vital signs and oxygenation, reduced postoperative nausea and vomiting (PONV), controlled postoperative pain, and patient or parents' satisfaction. Ketamine is a low-cost drug with a wide therapeutic window. Ketamine is a competitive N-methyl-D-aspartate receptor antagonist with good analgesic properties and periprocedural amnesia. The ketamine/midazolam combination was administered in different ways with controversial results about their effect on the EA and recovery profile. Ketofol, a mixture of ketamine and propofol, has been used in different favorable recovery profiles regarding postoperative EA and PONV. This study aims to evaluate the effect of premedication with an intramuscular ketamine/ midazolam combination versus pre-extubation ketofol on the EA and the recovery profile.

NCT ID: NCT06010134 Recruiting - Clinical trials for Osteogenesis Imperfecta

Osteogenesis Imperfecta and Balance

Start date: May 1, 2023
Phase: N/A
Study type: Interventional

Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. Its severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems and problems with the teeth. Physiotherapy is aimed to strengthen muscles and improve motility in a gentle manner, while minimizing the risk of fracture, and the use of support cushions to improve posture.

NCT ID: NCT06009874 Recruiting - Clinical trials for Myocardial Infarction

Clinical Investigation of the Cardioprotective Effect of Early Administration of SGLT2 in Patients Presented With AMI

Start date: October 2023
Phase: N/A
Study type: Interventional

This study aims to investigate the effect of early administration of DAPA during ischemia and before pPCI on infarct size, reperfusion injury-related myocardial damage, cardioprotection from HF, and renoprotection from AKI in patients with AMI.

NCT ID: NCT06009445 Recruiting - Sepsis Clinical Trials

Renal Resistive Index as a Predictor of Acute Kidney Injury and Evaluation of Fluid Administration in Sepsis

Start date: July 1, 2023
Phase:
Study type: Observational

We aim from this study to investigate the role of renal resistance index (RRI) in evaluation of Acute kidney injury development and fluid administration in sepsis patients considering the change in RRI values over 7 days from admission as a predictor of AKI development

NCT ID: NCT06009328 Recruiting - Overweight Children Clinical Trials

Fundamental Movement Skills, Body Mass Index and Quality of Life in Children

Start date: February 1, 2023
Phase:
Study type: Observational

Early childhood obesity is a serious worldwide problem, and fundamental movement skills (FMS) are very important factors in human movement. Thus, several advanced studies have examined the associations between FMS, body mass index (BMI) and quality of life. The purpose of this study was to investigate the relation between FMS, BMI and quality of life in Egyptian school aged children.

NCT ID: NCT06009263 Recruiting - Clinical trials for Mechanical Low Back Pain

Effect of Open Chain Versus Closed Chain Segmental Control Exercises on CSA of Lumbar Multifidus Muscle in Chronic MLBP

Start date: September 2, 2023
Phase: N/A
Study type: Interventional

To investigate the effect of adding open versus closed chain segmental control exercises to conventional treatment program on pain intensity, lumbar ROM, and CSA of multifidus muscle.