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Clinical Trial Summary

Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a group of genetic disorders that mainly affect the bones. It results in bones that break easily. Its severity may be mild to severe. Other symptoms may include a blue tinge to the whites of the eye, short height, loose joints, hearing loss, breathing problems and problems with the teeth. Physiotherapy is aimed to strengthen muscles and improve motility in a gentle manner, while minimizing the risk of fracture, and the use of support cushions to improve posture.


Clinical Trial Description

This study aimed to assess the efficacy of Whole Body Vibration on balance and motor function in children with Osteogenesis Imperfecta. Whole body vibration (WBV) therapy is targeted at musculoskeletal strengthening and has been trialed in a variety of conditions. WBV has been shown to have therapeutic advantage in various osteopenic preclinical models and populations such as postmenopausal women (improved mobility, muscle strength, postural strength, and bone density) and children with osteogenesis imperfecta (improved mobility) ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06010134
Study type Interventional
Source South Valley University
Contact Nehad Abo-zaid, Assistant Professor
Phone +201008980727
Email dr.nehadahmed@svu.edu.eg
Status Recruiting
Phase N/A
Start date May 1, 2023
Completion date September 30, 2023

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