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Diabetes Mellitus, Type 2 clinical trials

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NCT ID: NCT03885869 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

Relationships Between Joint Position Sensation, Plantar Sensation, Balance and Dual Task Performance in Type 2 Diabetics

Start date: March 25, 2019
Study type: Observational

Diabetes is a chronic disease characterized by hyperglycemia, which occurs when insulin is inadequate or the body's produced insulin cannot be used effectively, but according to the World Health Organization 2016 Global Report on Diabetes, it is an important public health problem that is one of the four priority non-infectious diseases. In addition to high mortality rates caused by diabetes-related complications, it is known that it can cause low quality of life and many additional problems in individuals. These complications and damage, which may be caused by diabetes, may result in reduced blood flow combined with neuropathy; As a result, foot ulcers, infections and consequently the need for amputation may increase. In addition to the additional complications caused by diabetic neuropathy, protective plantar sensory loss and decreased joint position have been reported in the literature. In particular, we did not find any comprehensive studies examining the relationship between these sensory changes and the double task performance in diabetic subjects. In our study, we aimed to investigate the relationship between joint position sense, plantar sensation, balance and double task performance in individuals with type 2 diabetes and to contribute to the literature with evidence-based, objective results.

NCT ID: NCT03884920 Not yet recruiting - Diabetes Mellitus Clinical Trials

Effective Enhancement of Glucose Tolerance and Prevention of Diabetes Mellitus Type 2 by Polyherbal Formulation

Start date: March 20, 2019
Study type: Observational

Primary protocol to this study is to develop a natural remedy to prevent diabetes mellitus in pre-diabetic state and elaborate the effectiveness of polyherbal formulation for carrying out Phase-II, III and IV. It also aimed at to see the level of difference of glucose tolerance and impaired fasting glucose and impaired glucose tolerance between pre-diabetic and diabetic to evaluate the potential benefit for treatment of insulin resistance and sensitivity. To see the for prevention of Diabetes Mellitus (DM) and stopping / delaying the onset of DM.

NCT ID: NCT03883412 Recruiting - Type2 Diabetes Clinical Trials

Effect of Exercise and/or Liraglutide on Vascular Dysfunction and Insulin Sensitivity in Type 2 Diabetes ( ZQL007)

Start date: February 28, 2019
Phase: Phase 4
Study type: Interventional

The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 16 weeks of intervention.

NCT ID: NCT03882970 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

A Study of Tirzepatide (LY3298176) Versus Insulin Degludec in Participants With Type 2 Diabetes

Start date: April 1, 2019
Phase: Phase 3
Study type: Interventional

The purpose of this study is to compare the effect of the study drug tirzepatide to insulin degludec on blood sugar levels in participants with type 2 diabetes. The study will last about 59 weeks and may include up to 22 visits.

NCT ID: NCT03881995 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

Effects of Insulin Glargine and Lixisenatide on the Brain

Start date: March 18, 2019
Phase: Phase 4
Study type: Interventional

1. Background During the last years, the brain has been identified as a major insulin-sensitive organ . The investigators and also other scientists identified hypothalamus, fusiform gyrus and prefrontal cortex as major insulin-sensitivity brain areas in humans . Brain insulin action regulates important physiological functions in humans such as food intake, body weight regulation, and cognition. Furthermore, animal studies suggest that insulin action specifically in the brain is involved in the control of peripheral glucose metabolism via regulation of the sensitivity to insulin in the rest of the body. Recently, the investigators were able to replicate these findings in humans: The investigators measured whole-body insulin sensitivity in combination with the well-established experimental delivery of human insulin to the brain via an intranasal approach. Peripheral insulin sensitivity was profoundly improved by brain insulin action in lean but not in obese healthy volunteers. What determines the effectiveness of this brain-derived pathway is still unknown. Furthermore, insulin resistance of the brain is linked to neurodegenerative diseases possibly explaining the elevated risk for such diseases in patients with type 2 diabetes. GLP-1 receptor agonists have been shown to acutely modulate appetite- and reward-related brain areas in humans. Research in animals suggest a close interaction between insulin and GLP-1 action especially in homeostatic centers of the hypothalamus. In this context, it is important that GLP-1 sensitivity of the brain is still present in the insulin resistant human brain. The investigators therefore hypothesized that GLP-1 agonists are able to improve insulin sensitivity of the brain; this might be one mechanism how GLP-1 agonists lead to weight loss and improved glucose metabolism. This might also have beneficial implications for cognitive function. However, at present, there are no human studies examining the effect of a GLP-1 agonist on brain activity and especially insulin action in the brain in patients with type 2 diabetes mellitus (T2D). Furthermore, there is no study in humans examining the effect of newly initiated insulin therapy on brain activity and especially insulin action in the brain in patients with T2D. 2. Rationale Based on the close interplay between hypothalamic insulin and GLP-1 signalling, the investigators hypothesize that the antidiabetic therapy with insulin glargine/lixisenatide combination (iGlarLixi) induces improved hypothalamic and prefrontal insulin sensitivity compared to a therapy with insulin glargine alone. This could underlay iGlarLixi's beneficial effects on body weight and whole-body glucose homeostasis. 3. Objective To assess whether treatment with iGlarLixi versus insulin glargine changes brain regional insulin sensitivity and thereby glucose metabolism, eating behaviour, and cognition in patients with type 2 diabetes insufficiently controlled with oral antidiabetic drugs (OAD).

NCT ID: NCT03878706 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

The Cardiovascular Effect of GLP-1 Agonist, SGLT2 Inhibitor and Their Combination

Start date: November 3, 2017
Study type: Observational [Patient Registry]

A. Four groups of patients with type 2 diabetes mellitus with high cardiovascular risk will be studied before and after 3 months of treatment: - 40 patients treated with a combination of GLP1 analogue and SGLT2 inhibitor ± metformin - 40 patients treated with GLP-1 agonist as a second step after metformin - 40 patients treated with SGLT2 inhibitor as a second step after metformin - 40 patients treated with a combination of insulin and other antidiabetic agents (metformin - DPP4inhibitors) Individuals will be equal distributed as far as age, gender and body mass index concerned. In addition, patients suffered from kidney disease and retinopathy are excluded.

NCT ID: NCT03877783 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

Diet, Physical Exercise and Metabolic Control Intervention Among Individuals With Type 2 Diabetes Och Mild Cognitive Impairment

Start date: September 1, 2019
Phase: N/A
Study type: Interventional

The subjects will participate for a one-year-intervention. The interventions include (a) mediterranean diet (b) an individualized physical training program and (c) pharmacological treatment for type 2 diabetes (T2D) aimed to achieve individualized optimal goals, according to national guidelines, taking into account the risk of hypoglycemia. This multi-component intervention is more comprehensive than usual care, and it specifically focuses on vascular domains. The outcomes will be assessed after a second year of observation.

NCT ID: NCT03877523 Completed - Clinical trials for Diabetes Mellitus, Type 2

Cocarnit Effects on Macrophages Polarization

Start date: October 3, 2018
Phase: N/A
Study type: Interventional

Cocarnit is a metabolic complex containing disodium adenosine triphosphate trihydrate, cocarboxylase, cyanocobalamin and nicotinamide. Aim: To test the effects of Cocarnit on pro- and anti-inflammatory activation of blood-derived monocytes-macrophages from Type 2 diabetic patients. Study design: Measurements of stimulated and basal secretion of TNF-alpha and CCl-18 before and at 2 and 4 hours after single intramuscular administration of Cocarnit at first day and after 30 days of follow-up in 40 Type 2 diabetic patients with/without polyneuropathy. Methods: The profile of monocyte polarization was determined in vitro in primary cell culture of blood-derived monocytes-macrophages after pro-inflammatory stimulation by bacterial lipopolysaccharide and after anti-inflammatory stimulation by interleukin-4, according to tumor necrosis factor (TNF) and CCL18 chemokine secretion, respectively.

NCT ID: NCT03876015 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

A Research Study Looking at How Semaglutide Works in People With Type 2 Diabetes in United Kingdom, as Part of Local Clinical Practice (SURE UK)

Start date: April 1, 2019
Study type: Observational

The purpose of the study is to collect information on how semaglutide works in real world patients. Participants will get semaglutide prescribed by their study doctor. The study will last for about 6 to 8 months. The participants will be asked to complete some questionnaires about their health and their diabetes treatment. Participants will complete these during their normally scheduled visits with their study doctor.

NCT ID: NCT03871621 Not yet recruiting - Clinical trials for Type 2 Diabetes Mellitus

Left Ventricular Functional Changes of Uncontrolled Diabetes by Dapagliflozin Treatment Trial

Start date: April 1, 2019
Phase: Phase 4
Study type: Interventional

The primary purpose of this study is to evaluate the efficacy of the SGLT2 inhibitor dapagliflozin, as compared with standard care of diabetes, on left ventricular (LV) functional change in asymptomatic type 2 diabetes mellitus (DM) patient.