Clinical Trials Logo

Filter by:
  • Enrolling by invitation  
  • Page [1] ·  Next »
NCT ID: NCT06357338 Enrolling by invitation - Clinical trials for Invasive Breast Cancer

Differential Expression and Potential Value of c-MYC in Non-Invasive and Invasive Mammary Carcinoma

Start date: March 19, 2024
Phase:
Study type: Observational

Retrospective observational study to evaluate c-MYC expression in non invasive and invasive mammry carcinoma

NCT ID: NCT06354673 Enrolling by invitation - Clinical trials for Paroxysmal Sympathetic Hyperactivity

Stellate Ganglion Block Combined With Dexmedetomidine or Subanesthetic Ketamine Infusion for Treatment of Neurostorm.

Start date: April 4, 2024
Phase: N/A
Study type: Interventional

Neurostorming is a sudden and exaggerated stress response as a result of damage to the brain. With appropriate treatment and time, there is hope for individuals to overcome storming, regain consciousness, and work towards successfully recovering from brain injury. Most treatments for neurostorming involve the use of medications only such as dexmedetomidine, opioids, gabapentin and propofol to address secondary complications like high blood pressure and fever. These medications focus on slowing the body's stress response or relaxing the body. Stellate ganglion block (SGB) is a promising therapy for paroxysmal sympathetic hyperactivity (PSH), overcoming the limitations of systemic medications and may serve to recalibrate aberrant autonomic states. Ketamine is a potent dissociative agent which has sedative, analgesic and anesthetic properties beside its sympathomimetic effect. Its combination with stellate ganglion block is to oppose its sympathomimetic effect. Dexmedetomidine has analgesic and sedative effect which inhibits the sympathetic nerve activity through its action on the α2 receptor in the spinal cord. Hypothesis: Null hypothesis: There is no difference between the effects of stellate ganglion block combined with dexmedetomidine or subanesthetic ketamine infusion for treatment of neurostorm after traumatic brain injury in critically ill patients.Alternative hypothesis: There is a difference between the effects of stellate ganglion block combined with dexmedetomidine or subanesthetic ketamine infusion for treatment of neurostorm after traumatic brain injury in critically ill patients.which has sedative, analgesic and anesthetic properties beside its sympathomimetic effect. Aim of the work is achievement of effective treatment for the neurostorm after traumatic brain injury in critically ill patients with better outcomes and decrease intensive care unit (ICU) stay.

NCT ID: NCT06348758 Enrolling by invitation - Clinical trials for Health Knowledge, Attitudes, Practice

Knowledge, Attitudes, And Perceptions of a Group of Egyptian Dental Students Towards Artificial Intelligence

AIKnowledge
Start date: February 11, 2024
Phase:
Study type: Observational

In the context of this ongoing AI revolution, it is essential to ensure that current and future clinical practitioners are up to date regarding this technology's current state and potential. It is valuable to assess the current attitude of clinical dentists and undergraduate students in dentistry regarding the future role of AI. To the best of the author's knowledge, there is no study about Egyptian dental students' views and attitudes regarding the application of AI in dental practice. Therefore, this study aimed to evaluate the attitudes and perceptions of a group of dental students in Egypt towards AI.

NCT ID: NCT06345261 Enrolling by invitation - Clinical trials for Catheter Complications

Diphenhydramine in Catheter Related Bladder Discomfort

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

Diphenhydramine has H1-antihistamine action, it also possesses anti-muscarinic properties. Thus, diphenhydramine might be able to reduce the problem of catheter related bladder discomfort by inhibiting smooth muscle spasm of the urinary bladder via its anti-muscarinic action .

NCT ID: NCT06345248 Enrolling by invitation - Clinical trials for Transversus Abdominis Plane

Laparoscopic-assisted Versus Ultrasonography-guided Transversus Abdominis Plane Block in Laparoscopic Sleeve Gastrectomy

Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The transversus abdominis plane (TAP) block, whereby local anesthetic is injected between the internal oblique and transversus abdominis fascia to facilitate blockade of somatic afferents nerves, is an effective, non-narcotic adjunct incorporated into many ERAS protocols. We hypothesized that surgeon delivered LAP-TAPs would be non-inferior to anesthesia-delivered US-TAPs in terms of post-operative pain control

NCT ID: NCT06322082 Enrolling by invitation - Clinical trials for Stress Incontinence, Male

Pilates Training and Low Intensity Shock Wave Therapy for Post-prostatectomy Stress Incontinence

Incontinence
Start date: March 20, 2024
Phase: N/A
Study type: Interventional

120 Patients with urinary incontinence following radical prostatectomy would be randomly assigned to either 4 groups all receive conventional pelvic floor muscle exercises plus group A receive Pilates exercises and Low Intensity Extracorporeal Shock Wave Therapy, group B receive Low Intensity Extracorporeal Shock Wave Therapy, group C receive Pilates exercises and group D receive conventional pelvic floor muscle exercises. Assessment at baseline, immediately after the intervention, to evaluate the degree of urinary incontinence and quality of life after three months from treatment.

NCT ID: NCT06300645 Enrolling by invitation - Clinical trials for Recurrent Congenital Talipes Equinovarus

SPLATT to Peroneus Brevis vs TATT to Lateral Cuneiform

Recurrent CTEV
Start date: January 17, 2024
Phase: N/A
Study type: Interventional

Congenital talipes equinovarus, is a common congenital foot deformity involving hindfoot equinus and varus, along with mid-/forefoot adduction and cavus. Currently, the Ponseti method is the preferred initial treatment for idiopathic clubfoot1 . Despite the initial phase's remarkable efficacy in correcting clubfeet, there remains a notable recurrence rate after Ponseti treatment2 - Numerous studies demonstrate a very high success rate during early follow-ups, ranging from 92% to 100%3 - Nonetheless, recurrence remains a challenge for orthopedic surgeons. A common trigger for recurrence is the dynamic supination of the foot, which results from excessive activation of the tibialis anterior muscle during ankle dorsiflexion4 Multiple studies indicate that tibialis anterior tendon transfer (TATT) is an effective tool for management of clubfoot recurrence, particularly dynamic supination5 - The widely used technique involves transferring the entire tendon through a drill hole in the lateral cuneiform and anchoring it on the plantar aspect of the foot using a sewing button and felt pad6 - While effective, this procedure raises the risk of pressure sores due to button placement on the sole7 Split anterior tibialis tendon transfer (SPLATT) to peroneus brevis is a well-described treatment strategy of varus foot deformities in patients with neuromuscular disorders8 - The technique has been reported to achieve successful deformity correction while avoiding skin problems associated with external button placement on the sole of the foot in tendon-to-bone transfers8 The present study aims to assess the outcome of utilizing SPLATT to peroneus brevis procedure in the treatment of recurrent CTEV in comparison to the original total TATT to the lateral cuneiform

NCT ID: NCT06294535 Enrolling by invitation - Orbital Fractures Clinical Trials

The Accuracy of Reconstruction of Orbital Walls Fracture Using Prebent Mesh Versus Patient Specific Implant

Start date: December 11, 2023
Phase: N/A
Study type: Interventional

under GA, incision to access to orbital walls. Then insertion of prebent titanium mesh or customized titanium implant and fixation with miniscrews, examination of ocular motility using forced duction test followed by closure of flap.

NCT ID: NCT06294483 Enrolling by invitation - Clinical trials for Systemic Lupus Erythematosus

Comparison Between Early-onset and Late-onset Patients With Systemic Lupus Erythematosus.

Start date: January 10, 2024
Phase:
Study type: Observational

The present study aims to: Compare clinical features, hematological indices and disease activity between the early-onset and late-onset patients with systemic lupus erythematosus. Evaluate the relationship between hematological indices (mean platelet volume, platelet lymphocyte ratio and neutrophil lymphocyte ratio) and Systemic lupus erythematosus (SLE) disease manifestations and activity.

NCT ID: NCT06281288 Enrolling by invitation - Depression Clinical Trials

Cognitive-Behavioral Therapy With Exercise Training in Adolescent Females With Elevated Depression Symptoms

Start date: December 25, 2023
Phase: N/A
Study type: Interventional

PURPOSE: To Study the Effect of Cognitive-behavioral therapy combined with exercise training in adolescent females with elevated depression symptoms BACKGROUND: Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers" are preying on them. Teenagers are more likely than any other age group to experience psychological issues due to depression, Adolescents have gotten active attention from society for their mental health difficulties since they are a high-level reserve talent stratum in society. Adolescent depression rates have increased in recent years, and "silent killers" RESEARCH QUESTION: Is there is an effect of exercise on depression in adolescent girls.