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NCT ID: NCT03768843 Completed - Clinical trials for Tramatic Odontoid Fracture

Surgical Outcome of Type II Odontoid Fracture, Harms Technique

Start date: January 1, 2015
Phase: N/A
Study type: Interventional

Cervical trauma is a common cause of disability following spinal cord injury, especially in athletic populations. The biomechanics in the atlantoaxial joint carry more than 50% of the rotational movement which can be affected in transverse ligament tear associated with odontoid fracture type II. Odontoid fracture type II considered an unstable fracture with a high rate of non-union in conservative treatment. Limitation of the odontoid screws in some cases gives the chance of posterior cervical fixation to have the superior role. Use of polyaxial screws in Harms technique gives the best results in maintaining the majority of the biomechanics. Purpose: our aim in this study to evaluate Harms technique in those patients regarding pain improvement and restoration of the motor power and to report the complications. Study design: A retrospective case series study. We Used the Frankel grading system to evaluate the postoperative neurological state.

NCT ID: NCT03768167 Completed - Spinal Metastases Clinical Trials

Corpectomy With Pyramesh Titanium Cage Reconstruction in Dorsolumber Metastatic Lesions

Start date: August 1, 2014
Phase: N/A
Study type: Interventional

The vertebral column represents the most common bony site for metastasis with an incidence ranged from 30% to 70% in patients with metastatic neoplasms. The dorsal spine carries the highest frequent site for metastasis all over the vertebral column followed by the lumber spine. These metastatic lesions are clinical entities that often necessitate a complex spinal decompression and anterior reconstruction. Posterolateral approaches alone allow for excellent decompression with transpedicular fixation and safe visualization of the neural elements for corpectomy and reconstruction so the investigators can avoid the complications that can be happened with the staged surgery. Purpose: investigators' aim in the study is to report cases and evaluate investigators' approach for fixation and assess the postoperative period regarding pain improvement and neurological deficit.

NCT ID: NCT03767361 Recruiting - Oxidative Stress Clinical Trials

Study the Effect of Blood Transfusion on Oxidant-antioxidant Status in Premature Neonates

Start date: June 2015
Phase: Early Phase 1
Study type: Interventional

Primary aim is to evaluate the effect of blood transfusion on oxidant-antioxidant status in premature neonates. Secondary aim is to assess the effect of the age of transfused red blood cells on the biological markers of oxidative stress.

NCT ID: NCT03766594 Completed - Clinical trials for Miscarriage, Recurrent

Sildenafil Citrate in Early Unexplained Recurrent Pregnancy Loss

Start date: January 1, 2018
Phase: Phase 1
Study type: Interventional

Recurrent unexplained spontaneous miscarriage (RSM) is defined as three consecutive pregnancy loss prior to 20 weeks from the last menstrual period. 1% to 2% of women experience RSM. Treatment of URSM is a challenging issue. The currently available lines of treatment according to simplicity of use, reliability and degree of invasiveness include corticosteroids, sildenafil citrate, aspirin, heparin and immunoglobulins (besides good antenatal care), but up to now there are no prospective randomized studies, powerful enough, to determine a significant difference between these therapeutic protocols, with any of the above mentioned pharmacological agents. Sildenafil Citrate (Viagra®), a vasodilator, is also described as an anti-inflammatory agent. While improving uterine blood flow in the proliferative phase, NO may have detrimental effects at the level of the endometrium during the implantation window. The NO- mediated release of cytokines such as tumour necrosis factor- from activated natural killer cells has been implicated as a cause of implantation failure. Based on these observations, this study attempts was made to study uterine arteries and sub-endometrial blood flow during the luteal phase in normal fertile women and in patients with Unexplained recurrent miscarriage

NCT ID: NCT03766451 Recruiting - Clinical trials for Intravascular Volume

Noninvasive Assessment of Intravascular Volume Status for Postoperative Patients

Start date: November 10, 2018
Phase:
Study type: Observational

Ultrasound measurements of the inferior vena cava (IVC) have been proposed as a noninvasive tool to help guide fluid management. Well-established correlations exist between respiratory cycle-induced changes in IVC diameter and C entral Venous Pressure (CVP) . Beyond providing an estimate of CVP, the caval index, or percentage collapsibility of the IVC , has been proposed as a predictor of preload reserve. This noninvasive rapid measurement of CVP is especially important in critical care settings. It can help in differentiating hypovolemic, septic and cardiogenic shock. Changes in volume status will be depicted by change in the diameter of the IVC . However, the validity and reliability of sonographic assessment of the inferior vena cava have been matters of controversy, and its applicability has been shown to be limited by technical difficulties. Recent study has shown a significant relationship between the internal jugular vein/common carotid artery (IJV/CCA) cross-sectional area ratio and CVP in pediatric burn patients .

NCT ID: NCT03764904 Active, not recruiting - Clinical trials for Postextubation Stridor

Airway Ultrasound as a Predictor for Postextubation Stridor in Anterior Cervical Spine Surgery

Start date: December 1, 2018
Phase:
Study type: Observational

literature on use of the ultrasound (US) in extubation decisions in cervical spine surgery is scarce.The aim of this study will be to evaluate the utility of US as an aid for decision making for extubation in elective cervical spine surgery (anterior approach) operations and as a predictor for postextubation stridor in these operations

NCT ID: NCT03764345 Completed - Clinical trials for Hepatitis C, Chronic

Eight Weeks Sofosbovir/Ledipasvir in HCV Infected Children Aged 4 to 10 Years

Start date: May 15, 2018
Phase: N/A
Study type: Interventional

Recently the era of direct-acting antiviral drugs for hepatitis C treatment has changed the world map of HCV. Results in adults are promising. FDA approved only two drugs in the pediatric age group 12 to 17 years. Younger children are still on the wait list for treatment. The current study aimed to treat children aged between 3 and 12 years with half the adult dose of Sofosbuvir/Ledipasvir combination (Heterosofir).

NCT ID: NCT03764189 Not yet recruiting - Clinical trials for Class II Division 1 Malocclusion

Evaluation of Micro-osteoperforation on Rate of Maxillary En-masse Retraction

Start date: January 2019
Phase: N/A
Study type: Interventional

accelerated anterior teeth retraction with the help of microosteoperforation procedure and miniscrews.

NCT ID: NCT03763916 Not yet recruiting - Placenta Accreta Clinical Trials

Intraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta

Start date: December 2018
Phase: N/A
Study type: Interventional

80 Egyptian pregnant female patients will be enrolled in our prospective study. All candidates will have the diagnosis of placenta percreta [confirmed by 2D and 3D ultrasound and Doppler by senior sonographer]. All candidates will be scheduled for cesarean hysterectomy; patients will be randomized into two groups, first group will include 40 patients who will undergo cesarean hysterectomy with intraoperative ureteric dissection, and the second group will include the other 40 patients who will undergo cesarean hysterectomy with preoperative ureteric stenting.

NCT ID: NCT03763578 Not yet recruiting - Dental Caries Clinical Trials

Dental Caries Prevention by a Natural Product

Start date: December 1, 2018
Phase: N/A
Study type: Interventional

The objective is to conduct an RCT to evaluate the effectiveness of Licorice in comparison to standard caries preventive measures for the prevention of new carious lesions in high caries risk patients.