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NCT ID: NCT03846284 Active, not recruiting - Postoperative Pain Clinical Trials

Caudal Versus Intravenous Magnesium Sulfate on Emergence Agitation After Sevoflurane In Children.

Start date: October 8, 2017
Phase: N/A
Study type: Interventional

Sevoflurane is the agent of choice for induction and maintenance of day care anesthesia in children and has a wide acceptance among pediatric anesthesiologists. Emergence agitation (EA) is a frequent postoperative complication in pediatric patients receiving inhalational anesthetics with a rapid recovery, e.g. sevoflurane Magnesium sulfate is a non anesthetic N-methyl-D-aspartate receptor antagonist, Regional anesthetic techniques have major two benefits which are lowering anesthetic requirements intraoperatively and providing adequate postoperative pain relief. Magnesium sulfate is an adjuvant that alters the perception and duration of pain by serving as an antagonist of N-methyl-D-aspartate glutamate receptors. Caudal injection of bupivacaine with magnesium sulfate in pediatric patients after inguinoscrotal operations provided adequate postoperative analgesia without producing many side effects. Caudal block with local anesthetic with or without adjuvants may prevent emergence agitation with effective postoperative pain management. - So the aim of this study is to compare the efficacy of caudal versus intravenous magnesium sulfate infusions in controlling emergence agitations after inhalational sevoflurane anesthesia in children who will undergo lower abdominal surgeries. Participants and methods All participants will receive caudal block with bupivacaine 0.25% 1mg/kg dialed in 10 cm saline. The participants will be divided to 3 groups 1. Bupivacaine group (B group) (group 1) N = 31 :- 2. Magnesium sulfate caudal group (MC group) (group 2) N = 31 :- 3. Magnesium sulfate I.V group (MV group) (group 3) N = 31 :- Postoperative assessment in the ( PACU):- - The oxygen saturation (SO2), heart rate (HR), and mean arterial pressure (MAP) are monitored by the observer blinded to group allocation on admission and 10 mins till discharge (0, 10, 20, 30, 40, 50, 60mints, time of discharge) from the PACU. - Emergence agitations (Pediatric anesthesia emergency delirium scale (PAED) The presence of Emergence agitation and its severity will be measured using (PAED). The presence of Pain and its severity will be measured using FLACC scale. - Time of first postoperative administration of fentanyl in mints - Modified Aldrete score :- The discharge from the PACU will be measured using Modified Aldrete score.

NCT ID: NCT03845595 Completed - Clinical trials for Stroke, Cardiovascular

Cortical Excitability Sequential Changes in Response to Transcranial Magnetic Stimulation Post Stroke

Start date: January 14, 2018
Phase: N/A
Study type: Interventional

This study was conducted to investigate the cortical excitability changes per session in response to the application of low frequency repetitive transcranial magnetic stimulation *LF-rTMS* on the contralesional hemisphere and its impact upon the upper limb motor performance post stroke. As well as, the minimum and maximum number of (LF-rTMS) sessions that would be recommended to achieve boosted enhancement in the cortical excitability findings and subsequently its impact upon the functional performance of the upper limb in stroke patients.Half of the patients were treated with the contralesional (LF-rTMS) in addition to conventional upper limb physical therapy interventions, while the other half received the conventional upper limb physical therapy interventions.

NCT ID: NCT03845361 Not yet recruiting - Clinical trials for Peripheral Perfusion

Radial Artery Cannulation and Perfusion Index

Start date: February 22, 2019
Phase: N/A
Study type: Interventional

This study aims to investigate if radial artery cannulation of the dominant hand affects its peripheral perfusion during cardiac surgery using cardiopulmonary bypass.

NCT ID: NCT03845153 Recruiting - Bone Fracture Clinical Trials

Metformin Effect on Fracture Healing in Post-Menopausal Women

Start date: November 1, 2018
Phase: Phase 4
Study type: Interventional

study the effect of metformin drug on fracture healing of patients with high risk of delayed fracture healing or non-union and correlating this to serum irisin myokine level.

NCT ID: NCT03844971 Recruiting - Clinical trials for Temporomandibular Disorder

Computer Guided Arthrocentesis of Temporomandibular

Start date: January 12, 2019
Phase: N/A
Study type: Interventional

Computer guided arthrocentesis of temporomandibular joint for patients with anterior disc displacement with reduction using patient specific guide

NCT ID: NCT03844581 Completed - Clinical trials for Interstitial Cystitis

Effect of Interferential Electrical Stimulation on Pain Perception and Disability Level on Interstitial Cystitis

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Start date: January 1, 2019
Phase: N/A
Study type: Interventional

A total of 40 volunteers women with a diagnosis of interstitial cystitis. Their ages ranged from 25 to 40 years old; their body mass index was > 30 kg/m2 and were randomly assigned to a group (A) received interferential current at the lower abdomen, and also received traditional medicine or group (B) received traditional medicine for 8 successive weeks. Both of the groups received the treatment program for 8 successive weeks. Assessment of pain perception and disability level for all patients in both groups (A&B) were done through Visual analogue scale, O'Leary-Sant Symptom Index or Interstitial Cystitis Index (ICSI) and blood cortisol concentration were done before and after the treatment program.

NCT ID: NCT03843827 Completed - LMA Vs I Gel Clinical Trials

Randomized Comparative Study Between Classic Laryngeal Mask Airway and I Gel Airway in Obese Patients Having BMI 35-40 During Elective Non Abdominal Surgery.

Start date: January 9, 2018
Phase: N/A
Study type: Interventional

Invistigators study both supraglottic airway devices; the classic LMA and the I GEL mask are satisfactory devices providing high airway leaking pressures. Although both devices provide high airway leaking pressures, Invistigators study revealed that the I gel mask provides a better seal with the glottic aperture and shorter time of insertion than cLMA. Both devices showed also effective ventilation, more hemodynamic stability and no episode of hypoxia with minimal post-operative complications.

NCT ID: NCT03841916 Recruiting - Clinical trials for Postmenopausal Bleeding

Relation Between Body Mass Index and Endometrial Thickness

Start date: June 5, 2018
Phase:
Study type: Observational

Postmenopausal Bleeding (PMB) is defined as recurrent attacks of bleeding occurring in women after menopause one year at least after stoppage of cycles [

NCT ID: NCT03841591 Completed - Clinical trials for Gestational Diabetes

Maternal Weight Gain in Gestational Diabetes Controlled by Metformin Versus Insulin

Start date: February 1, 2018
Phase: Phase 3
Study type: Interventional

Insulin has many disadvantages for mothers with GDM including the need to give injections, frequent daily testing for monitoring, and risks of hypoglycemia, increase in appetite, weight gain and high cost. Metformin, an oral biguanide, may be a more logical alternative to insulin for women with GDM who are unable to cope with the increasing insulin resistance of pregnancy. This study aim to compare maternal weight gain during pregnancy in women with gestational diabetes, treated by insulin versus metformin.

NCT ID: NCT03840538 Completed - Sjogren's Syndrome Clinical Trials

Probiotics as a Prophylaxis to Prevent Clinical Manifestations of Oral Candidosis in Patients With Sjogren's Syndrome

Start date: January 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

Sjogren's syndrome is an autoimmune chronic disease. It has two forms Primary Sjogren's syndrome charactrized by dry eyes and dry mouth. Secondary Sjogren's syndrome characterized by rheumatoid diseases as rheumatoid arthritis, scleroderma and lupus erythematosus. SS patients are most liable to oral candidiasis , so they need prophylaxis aganist oral candidiasis. Probiotic bacteria are live microorganisms that when administered in adequate amounts confer benefits to health.Probiotics are commonly used as a prophylaxis aganist oral candidosis.