Coronary Artery Disease Clinical Trial
Official title:
Functional Diagnostic Accuracy of Quantitative Flow Ratio in Tandem Lesions and Virtual Stenting
Quantitative Flow Ratio (QFR) is a novel method for evaluating the functional significance of
coronary stenosis. Virtual stent implantation technique combined with QFR was recently
developed to predict the functional significance of coronary stenosis as if the stenosis was
revascularized.
The purpose of this study is to evaluate the diagnostic accuracy of QFR in in tandem lesions
with fractional flow reserve (FFR) as the reference standard. The secondary purpose is to
evaluate the diagnostic accuracy of QFR-based virtual stent technique in predicting the FFR
values after revascularizing the culprit lesion.
QFR is a novel method for evaluating the functional significance of coronary stenosis by
calculation of the pressure drop in the vessel. 3D coronary models can be reconstructed based
on two angiographic projections to obtain the geometric parameters, including vascular
diameter or cross-sectional area. According to the lesion stenosis, vessel curvature, conical
geometry and reference lumen characteristics, pressure drop can be calculated in real time
based on its relationship with blood flow. There is no need for pressure wire and adenosine /
ATP induced maximum hyperemia compared with FFR.
The FAVOR Pilot Study and FAVOR II China Study showed promising results for diagnostic
accuracy in consecutive patients. However, the diagnostic accuracy of QFR in specific tandem
lesions needs further investigation. Furthermore, using the virtual stent technology to
accurately assess the culprit lesion and choose the optimal treatment is significant in
precisely guiding PCI surgery.
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