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Breast Cancer clinical trials

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NCT ID: NCT03658213 Not yet recruiting - Breast Cancer Clinical Trials

To Compare ZOLADEX 10.8 mg With ZOLADEX 3.6mg in Chinese Pre-menopausal ER+ HER2- Early Breast Cancer.

LARES
Start date: November 5, 2018
Phase: Phase 3
Study type: Interventional

This study will recruit 168 patients in approximately 20 study centres in China. The primary objective of this study is to examine whether ZOLADEX 10.8 mg depot is non-inferior to ZOLADEX 3.6 mg depot in terms of the suppression rate of serum estradiol (E2) to the menopausal level (≤30 pg/mL) from Week 4 through Week 24.

NCT ID: NCT03657628 Not yet recruiting - Breast Cancer Clinical Trials

Physical Activity, Proliferation and Immune Markers in Benign Breast Tissue

Start date: August 31, 2018
Phase: N/A
Study type: Interventional

This research study is evaluating the effect of exercise on markers in breast tissue and blood of premenopausal women who have been found to have dense breast tissue on mammogram.

NCT ID: NCT03656731 Not yet recruiting - Breast Cancer Clinical Trials

Exercise in Older Women With Breast Cancer During Systemic Therapy

Start date: September 15, 2018
Phase: N/A
Study type: Interventional

BREACE is a prospective randomized controlled trial. The aim is to investigate the effect of an exercise-based intervention among older participants with breast cancer treated with adjuvant or first-line systemic therapy. The hypotheses: That the intervention will maintain or increase physical function levels, reduce symptoms and side effects, improve quality of life and psychological wellbeing, and prevent weight loss and muscle wasting

NCT ID: NCT03655600 Not yet recruiting - Breast Cancer Clinical Trials

Acupressure for Pain and Opioid Use Among Breast Cancer Patients

AcuPOP
Start date: September 4, 2018
Phase: N/A
Study type: Interventional

This study seeks to determine the feasibility of recruiting and training participants in self-acupressure, for women undergoing primary breast cancer surgery or delayed reconstruction surgery. The study seeks to determine also if self-acupressure is effective in reducing the need for opioids post-surgery and the effects on other life factors.

NCT ID: NCT03653988 Not yet recruiting - Breast Cancer Clinical Trials

Comparison of Pre-op and Post-op Pectoralis Nerve Block

Start date: September 2018
Phase: N/A
Study type: Interventional

The investigators will compare whether patients will have better pain control if they were to receive (PEC I/II block) before surgery or after mastectomy.

NCT ID: NCT03652935 Completed - Breast Cancer Clinical Trials

Mindfulness, Breast Cancer and Psycho-Immune Dysregulation

Start date: September 15, 2008
Phase: N/A
Study type: Interventional

The purpose of this study is to evaluate the benefits of a Mindfulness Based Stress Reduction (MBSR) program for psycho-immune dysregulation in women newly diagnosed with breast cancer compared to women with breast cancer completing an attention control condition (health education classes). Women will be randomized to either the MBSR or health education classes. They will complete psychometric instruments evaluating psychological outcomes and will provide blood samples for immune outcomes. They will also provide saliva samples for cortisol diurnal rhythm determination. Measures will be done longitudinally pre and post MBSR or health education program. It is hypothesized that MBSR participants will exhibit improved psychological and immunological outcomes over time, as compared to women randomized to the health education classes.

NCT ID: NCT03651973 Not yet recruiting - Breast Cancer Clinical Trials

Prevention of Sequelae Pain After Breast Cancer Surgery by Self-massages and Self Stretching. Impact of Learning Workshops.

ESTAUVAL
Start date: September 15, 2018
Phase: N/A
Study type: Interventional

Myofascial pain syndrome is a common cause of chronic pain characterized by myofascial pain and trigger points. Recommendations regarding management of pain after breast cancer don't mention myofascial syndrome despite a study suggests possible myofascial syndrome with roughly 75% of patients in pain. 144 patients having a local breast cancer requiring surgery will be randomized in this study, ratio 1:1 standard and experimental groups. Every patients (standard and experimental groups) will attend 4 specific consultations during which standard recommendations will be given, pain, quality of life, shoulder range of motion, global upper limbs force will be assessed. In addition, patient randomized in experimental group will attend self massages and self stretching workshops, one before surgery and one after surgery. Patients will be encouraged to performed daily self massages and self stretching. The aim of the study is to assess impact of self massages and self stretching workshops on sequelae pain further surgery for breast cancer.

NCT ID: NCT03651037 Not yet recruiting - Breast Cancer Clinical Trials

Physical Activity Platform to Improve Bone Health in Cancer Survivors

THRIVORS+BH
Start date: October 15, 2018
Phase: N/A
Study type: Interventional

Cancer treatment-induced bone loss and the subsequent risk of fractures in both men and women impacts not just survivors' quality of life, but is also a significant burden on national health care. Clinical studies have reported that moderate-intensity resistance exercises prevent a decline in bone health in female cancer survivors, and that strength training may reduce complications associated with cancer such as fatigue, muscle wasting, and bone loss. Unfortunately, only a small percentage of women who have had cancer, engage in and adhere to a strength training exercise routine. The investigators have developed an internet-based application, Thrivors, that guides cancer survivors through exercise routines with light-to-moderate strength training in the home setting, and connects them to survivorship resources. In this Phase I proposal, the investigators will develop and deploy an enhanced version, Thrivors+BH, that disseminates resistance training exercises specifically impacting bone health (BH), integrated with video-based interactive feedback and tracking of adherence to exercise routines. The goal is to validate Thrivors+BH as a novel tool to bridge the gaps between cancer survivorship, physical activity, value-based care and health care organizations (providers and payers), to positively impact bone health in breast cancer survivors.

NCT ID: NCT03650894 Not yet recruiting - Breast Cancer Clinical Trials

Nivolumab, Ipilimumab, and Bicalutamide in Human Epidermal Growth Factor (HER) 2 Negative Breast Cancer Patients

Start date: October 2018
Phase: Phase 2
Study type: Interventional

The goal of this protocol is to evaluate the safety and efficacy of an alternative systemic combination approach that omits or delays the use of chemotherapy in metastatic disease, while improving efficacy and durability of response. The approach combines two potentially effective and previously studied strategies: androgen receptor blockade and immune checkpoint therapy.

NCT ID: NCT03650868 Recruiting - Breast Cancer Clinical Trials

The Effect of Thoracal Paravertebral Block on Seroma Reduction in Breast Surgery, a Randomised Controlled Trial

Start date: July 2, 2018
Phase: N/A
Study type: Interventional

Thoracal paravertebral block (TPVB) is a commonly prefferred regional anesthesia technique to provide postoperative analgesia. In addition, the successful use of TPVB is reported for some seroma related pain cases. Postoperative analgesia in breast surgery is a difficult and overworked issue due to etensive surgery and complex innervation of the breast and in addition to this complex mechanisms, seroma accumulation has a negative effect for patients postoperatively. With this study, the investigators aimed to study the effect of TPVB on seroma reduction for breast cancer surgery.