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Breast Cancer clinical trials

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NCT ID: NCT03874325 Recruiting - Breast Cancer Clinical Trials

Aromatase Inhibitor and Durvalumab in Postmenopausal Breast Cancer

Start date: March 11, 2019
Phase: Phase 2
Study type: Interventional

This study is to find out if an investigational drug called Durvalumab (MEDI4736) given together with a standard of care aromatase inhibitor drug can help people with breast cancer.

NCT ID: NCT03873519 Recruiting - Breast Cancer Clinical Trials

Acute Effect of Chromatic Environment During Chemotherapy

Start date: April 15, 2018
Phase: N/A
Study type: Interventional

The primary objective is to examine the acute effect of color, room orientation (affecting amount of luminosity) on perceived health status and stress levels in oncologic patients during chemotherapy sessions at outpatient clinic. The secondary objectives will be to study the effect on vital signs (body temperature, heart rate, systolic blood pressure). Patients will be allocated into four conditions (Group A: Cold North, Group B: Cold South C: Warm North D: Warm South) for each session. For the next session, patients will be assigned a new condition. Assignment of sequences will be randomized for each patient. 20 patients will be randomly assigned to one of the four groups, after having signed the Free and Informed Consent Form and agreed to participate in the project, will respond to the evaluation form and will be submitted to physical examination. Patients will be treated per standard of care.

NCT ID: NCT03872908 Not yet recruiting - Breast Cancer Clinical Trials

Satisfaction & Efficacy of Compression Using Surgical Gloves in Chemo-induced Peripheral Neuropathies

ELEGANT
Start date: May 1, 2019
Phase:
Study type: Observational

Evaluation of Satisfaction & Efficacy of Compression Using Surgical Gloves in Peripheral Neuropathies Due to Chemotherapy

NCT ID: NCT03872505 Not yet recruiting - Breast Cancer Clinical Trials

Pre-operAtive Non-Anthracycline Chemotherapy, Durvalumab +/- RAdiation Therapy in Triple Negative Breast Cancer

PANDoRA
Start date: April 2019
Phase: Phase 2
Study type: Interventional

This phase II randomized trial is for patients with clinical stage II-III, ER and PR <10%, HER2-negative invasive breast carcinoma (triple negative breast cancer) for whom adjuvant RT is planned and pre-operative RT is deemed feasible by the treating radiation oncologist. Subjects will be randomized into arm A or B and treatment will last for 16 weeks. Both groups will receive Durvalumab 750mg IV Q2 weeks x 2 then a biopsy prior to durvalumab 1500mg IV Q4 weeks x 3 with paclitaxel and carboplatin IV weekly x 12. Arm B will receive radiation (24 Gy total) starting with the second durvalumab dose every other day (8Gy per fraction) for one week. Following treatment, subjects will receive SOC breast surgery and continue on to physician's choices SOC treatment during the 3 year follow up period. This study hopes to explore the impact of checkpoint blockade administration with a non- anthracycline chemotherapy regimen plus RT on post-surgery pathologic complete response (pCR) rate in the breast and axilla (ypT0/Tis ypN0) following 12 weeks of treatment and surgery.

NCT ID: NCT03872141 Recruiting - Breast Cancer Clinical Trials

Objective Evaluation of Paclitaxel/Docetaxel-induced Neuropathy in Breast Cancer Patients

Start date: May 23, 2017
Phase:
Study type: Observational

The purpose of this prospective, non-interventional study is to perform neurological and cognitive assessment of breast cancer patients who receive standard of care single agent weekly paclitaxelor docetaxel chemotherapy to determine the onset and severity of chemotherapy induced neuropathy (CIPN) and cognitive impairment (CICI).

NCT ID: NCT03870802 Not yet recruiting - Breast Cancer Clinical Trials

MACSSI (MAstectomie Cellules Souches Surveillance Immunitaire)

MACSSI
Start date: May 15, 2019
Phase:
Study type: Observational

Monocentric, observational and prospective study in adult women having an early-stage breast cancer without genetic risk. The main objective is to characterize quantitatively and qualitatively, after solitary confinement, the resident breast stem cells and the immune system cells infiltrated in the mammary gland in women: - With a moderate risk of breast cancer progression (women with an early "Luminal A" tumor) = Group A. - With a high risk of breast cancer progression (women with an early "Luminal B" or basal tumor) = Group B.

NCT ID: NCT03870620 Recruiting - Breast Cancer Clinical Trials

Metastatic Breast Cancer in Austria

Start date: June 15, 2015
Phase:
Study type: Observational [Patient Registry]

Breast cancer is the most common cancer among women worldwide. In Austria, this diagnosis is made more than 5000 times a year (STATISTICS AUSTRIA, Austrian Cancer Registry, as of 24.09.2012). Of these, already 5% to 10% have distant metastases at the time of initial diagnosis, and up to 30% of the node-negative tumours and up to 70% of the node-positive tumours metastasise at a later date. Metastatic breast cancer has not been systematically assessed in Austria to date. This medical registry of the AGMT is thus the first Austrian-wide standardised documentation of this disease. The aim of the registry is to answer both epidemiological and therapy-specific questions. This registry is a prospective and retrospective, multicentre collection of data on patients with metastatic breast cancer in Austria. All tumour characteristics, medical histories and also treatment sequences are documented in anonymised form.

NCT ID: NCT03868865 Completed - Breast Cancer Clinical Trials

Effects of an Integrative Day-care Clinic Program for Breast Cancer Patients During Chemotherapy

Start date: August 7, 2012
Phase: N/A
Study type: Interventional

The aim of the study was to evaluate a new integrative day-care clinic concept for breast cancer patients receiving chemotherapy. This is an explorative pilot study. Therefore, all outcomes are analyzed exploratively.

NCT ID: NCT03866655 Not yet recruiting - Breast Cancer Clinical Trials

Evaluating a Digital Tool for Supporting Breast Cancer Patients

ADAPT
Start date: April 2019
Phase: N/A
Study type: Interventional

This is a prospective randomised controlled trial that aims to understand the impact of the OWise breast cancer digital tool in newly diagnosed breast cancer patients. Half the patients will receive the digital tool and half the patients will receive standard information. The study will look at the impact of the digital tool on patient activation, health related quality of life (HRQoL), health status, psychological distress, NHS resource utilisation and health care costs.

NCT ID: NCT03865992 Recruiting - Breast Cancer Clinical Trials

Curcumin in Reducing Joint Pain in Breast Cancer Survivors With Aromatase Inhibitor-Induced Joint Disease

Start date: March 28, 2019
Phase: N/A
Study type: Interventional

This clinicaltrial studies how well curcumin works to alleviate symptoms resulting from aromatase inhibitors taken by postmenopausal women for estrogen receptor positive/progesterone receptor positive breast cancer.