Coronary Artery Disease Clinical Trial
Official title:
"Preventing Cardiovascular Ischemic Events and Arresting Their Consequences in Type 2 Diabetic Population: a Multidisciplinary Clinical and Experimental Approach" (PRECISED)
Current methods based on traditional Cardiovascular risk factors are not clinically useful
for identifying Type 2 Diabetes patients at risk of developing acute Cardiovascular ischemic
events (ie.myocardial infarction or stroke). In addition, Cardiovascular ischemic events in
Type 2 Diabetes population have worse prognosis than in general population. In fact, there is
sufficient experimental evidence indicating that diabetes exaggerates the deleterious effects
of ischemic events and worsens their outcome.
A prolonged sub-clinical phase exists before a Cardiovascular event occurs in Type 2 Diabetes
patients. Therefore, new strategies aimed at identifying those patients with this subclinical
Cardiovascular Diabetes and, consequently, more prone to develop Cardiovascular events is a
challenge to be met.
Objectives
1) To examine whether the extension and degree of microangiopathy is an independent risk
factor for silent myocardial and brain ischemia. 2) To evaluate whether the degree and
extension of microangiopathy is a predictor of CV events and poor outcome. 3) To evaluate
whether a new score based on the extension and the degree of microangiopathy will permit us
to improve the current methods used to identify patients at risk of CVD and its outcomes. 4)
To determine whether the presence and the degree of NAFLD is an independent Cardiovascular
disease risk factor and represent and extra-value to the score based on the extension and the
degree of microangiopathy.
Secondary objectives:
1) To examine the usefulness of selected serum biomarkers in identifying diabetic patients at
risk of Cardiovascular disease 2) To evaluate whether these selected biomarkers are related
to the degree and extension of microangiopathy and the outcome of cardiovascular events. 3)
To better define the meaning of microalbuminuria in type 2 diabetic population (glomerular
involvement vs. index of generalized endothelial dysfunction)
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