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Evaluation of Low Dose Colchicine and Ticagrelor in Prevention of Ischemic Stroke in Patients With Stroke Due to Atherosclerosis — RIISC-THETIS  

Stroke Clinical Trial

Official title:
Reducing Inflammation in Ischemic Stroke With Colchicine, and Ticagrelor in High-risk Patients-extended Treatment in Ischemic Stroke

Clinical Trial Summary

REDUCING INFLAMMATION IN ISCHEMIC STROKE WITH COLCHICINE, AND TICAGRELOR IN HIGH-RISK PATIENTS-EXTENDED TREATMENT IN ISCHEMIC STROKE.

Clinical Trial Description

Our main hypothesis is that low-dose colchicine (0.5 mg/day) on top of best medical care, in patients with an ischemic stroke with ipsilateral atherosclerotic stenosis, will reduce the risk of major vascular events after 36-60 months of treatment as compared to no colchicine. Our second main hypothesis, tested in 2x2 factorial design, is that ticagrelor 90 mg bid in the same patients, will reduce the long-term risk of major vascular events (after 36-60 months of treatment) as compared to aspirin 75-300 mg/day. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05476991
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Pierre Amarenco, Pr
Phone 140258725
Email pierre.amarenco@gmail.com
Status Recruiting
Phase Phase 3
Start date May 17, 2023
Completion date September 1, 2027
View Details
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