The Association Between Obesity-Related Indicators and Adverse Outcomes in Ischemic Stroke Patients

Stroke, Ischemic Clinical Trial

Official title:

Obesity and Stroke: Exploring the Clinical Connection Through Epidemiology and Molecular Medicine

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06165107
• Other study ID #: TJ-IRB20230830
• Status: Completed
• Start date: January 1, 2012
• Est. completion date: January 31, 2022

Study information

• Verified date: December 2023
• Source: Tongji Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study population comprised patients experiencing acute first-ever ischaemic stroke, with diagnostic criteria established in accordance with the International Classification of Diseases, Ninth Revision. All subjects presented rigorous neuroimaging evidence, including head computed tomography and/or magnetic resonance imaging, which underwent review by two or more experienced neuroradiologists. Adverse outcomes were characterized as compliant endpoint events, encompassing mortality and recurrences. The primary outcome was adverse outcomes and the secondary outcome was recurrence-free survival (RFS).

Description:

Clinical data for the derivation cohort were acquired from three medical facilities: Tongji Hospital Sino-French New City Branch in Caidian District, Tongji Hospital Qiaokou Branch in Hankou District, and Tongji Hospital Optics Valley Branch in Wuhan East Lake High-Tech Development Zone. The clinical data were sourced from the electronic medical records of Tongji Hospital, the largest healthcare facility in the Hubei region of China. Its comprehensive electronic medical record system comprises over 60 million medical records spanning from 1980 to the present. We retrospectively gathered information on patients admitted for acute first-ever ischaemic stroke between January 2012 and January 2022. The following individuals were excluded from the study: 1) Those under 18 years of age; and 2) Pregnant women.

The variables gathered included the primary test parameters of patients within 24 hours of admission, encompassing age, gender, smoking and alcohol consumption status, arterial blood pressure, fat-related indicators, comorbidities, and the primary treatments administered within the initial 24 hours.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45162
• Est. completion date: January 31, 2022
• Est. primary completion date: January 31, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• We retrospectively gathered information on patients admitted for acute first-ever ischaemic stroke between January 2012 and January 2022.

Exclusion Criteria:

1. Those under 18 years of age; and 2) Pregnant women.

Related Conditions & MeSH terms

• Ischemia
• Ischemic Stroke
• Obesity
• Stroke
• Stroke, Ischemic

Intervention

Other:
• No intervention
No intervention

Locations

Country	Name	City	State
China	Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology	Wuhan	Hubei

Sponsors (1)

Lead Sponsor	Collaborator
Qin Zhang

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Mortality	Death	10 years
Primary	Recurrence	Recurrent stroke	10 years