Posterior Circulation ASTRAL Prognostic Score

Stroke Ischemic Clinical Trial

Official title:

Pc-ASTRAL Score for the Prediction of 3 Months Functional Outcome in Acute Ischemic Stroke at the Posterior Circulation

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT05906420
• Other study ID #: pc-ASTRAL
• Status: Active, not recruiting
• Start date: January 1, 2003
• Est. completion date: August 31, 2023

Study information

• Verified date: June 2023
• Source: University of Thessaly
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The goal of this study is to develop a prognostic score for ischemic posterior circulation strokes, based on our previous work on with the ASTRAL scores (Acute STroke Registry and Analysis of Lausanne) on overall stroke prognosis, intracranial occlusion, recanalization and stroke recurrences. The main question it aims to answer is the modified Rankin score in 3 months after the event.

Participants will be patients with acute ischemic stroke of the posterior circulation with mRS priot to event <3. All the data will be collected retrospectively from patients included in the ASTRAL registry between January 2003 and December 2021. The ASTRAL registry will be used as the derivation cohort of the score. Demographics, acute glucose, NIHSS score and acute imaging of each participant will be used from the derivation cohort in order to create an integer-based prognostic score. After internal validation, we plan to validate the score in external stroke registries to show its validity.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 2000
• Est. completion date: August 31, 2023
• Est. primary completion date: December 31, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Isolated posterior circulation strokes based on clinical or/and imaging evidence.

• Arriving within 24h at hospital since last proof of good health.

Exclusion Criteria:

• no available data for 3 months modified Rankin Score

• modified Rankin Score=3 prior the event

Related Conditions & MeSH terms

• Brain Infarction
• Infarction
• Ischemic Stroke
• Posterior Circulation Brain Infarction
• Stroke
• Stroke Acute
• Stroke Ischemic

Intervention

Diagnostic Test:
• ASTRAL prognostic score
ASTRAL prognostic score

Locations

Country	Name	City	State
Greece	Medical School, University of Thessaly, Larissa University Hospital	Larissa	Thessaly
Switzerland	Stroke Center, Department of clinical neurosciences, Lausanne University Hospital and University of Lausanne	Lausanne	Vaud Canton

Sponsors (2)

Lead Sponsor	Collaborator
University of Thessaly	University of Lausanne

Countries where clinical trial is conducted

Greece,  Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	3 months modified Ranking scale	evaluation of 3 months neurological disability	January 2003-December 2021