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Stroke, Acute clinical trials

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NCT ID: NCT05874661 Recruiting - Stroke, Acute Clinical Trials

FOA on Sit to Stand in Individuals Post Stroke

Start date: April 2, 2023
Phase: N/A
Study type: Interventional

Focus of attention refers to what a person is thinking about during a task, with an internal focus being thinking about what one's body is doing and an external focus being thinking about a target or outcome in the environment. The purpose of this study is to fill some of the gaps in the literature by examining the effects of focus of attention on performance and learning of sit to stand in individuals post stroke. This study will investigate whether an internal or external focus of attention can lead to improved use of the affected lower extremity during the sit to stand transition, while maintaining an upright trunk position.

NCT ID: NCT05874596 Not yet recruiting - Stroke, Acute Clinical Trials

Whole-process Quality Improvement of Endovascular Treatment Basd on an AI-aided Clinical Feedback System

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

A clustered randomized control trial to evaluate whether multi-aspect intervention based on an AI-aided clinical feedback system could improve the quality of EVT and functional outcome of patients.

NCT ID: NCT05869565 Recruiting - Stroke, Acute Clinical Trials

Best Solution Identification to Prevent Hyperchloremia Combinations of Sodium Chloride and Sodium Acetate IV Fluids Along With Standard of Care Treatment in Acute Stroke Patients

sodium acetate
Start date: February 1, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

Hypothesis: Hyper chloremia is associated with poor outcome in Intracerebral Hemorrhage (ICT). Hyperchloremia is defined as serum chloride level of 110mmol/L or greater. This clinical study is assuming that, by increasing the ratio of Sodium-acetate to Sodium-chloride solutions in IV treatment, the incidence of Hyperchloremia can be lowered significantly. This result can be demonstrated by measuring serum chloride levels at Baseline, 24Hr, 48Hr and 72 Hours' time intervals and compare them between the three treatment and one Control arm. Intervention (drug/biologic/device/behavioral): Phase 2-dose finding Patients will be enrolled in the study and randomized into one of the four study treatment arms(target fluid administration rate 1 ml/kg/hour) initiated within 12 hours. IVF will be prepared in the main hospital pharmacy. 1. Sodium chloride (0.9%) referred as 0.9% NaCl for 72 hours post symptom onset (60-72 hourspost randomization); 2. Sodium chloride (0.9%) and sodium acetate (0.9%) mixture 3:1 ratio for 72 hours post symptom onset (60-72 hours post randomization); 3. Sodium chloride (0.9%) and sodium acetate (0.9%) mixture 2:1 ratio for 72 hours post symptom onset (60-72 hours post randomization); 4. Sodium chloride (0.9%) and sodium acetate (0.9%) mixture 1:1 ratio for 72 hours post symptom onset (60-72 hours post randomization).

NCT ID: NCT05864495 Not yet recruiting - Stroke, Acute Clinical Trials

Neuroimaging in Acute Stroke

e-Stroke
Start date: May 2023
Phase:
Study type: Observational [Patient Registry]

The main aim of this study is to identify the predictive value of CT parameters (e-ASPECTS, CTP, collateral vessel status, volume and location of ischemic lesion volume) at a 3 month functional outcome defined by the modified Rankin scale (mRS) in patients with non-lacunar stroke after recanalization treatment (Intravenous Thrombolitic Therapy and/or Mechanical Thrombectomy, or conservative treatment).

NCT ID: NCT05823298 Not yet recruiting - Stroke, Acute Clinical Trials

Turkish Adaptation and Psychometric Properties of Fugl-Meyer Assessment in Acute Stroke Patients

FMD
Start date: May 1, 2023
Phase:
Study type: Observational

The aim of this methodological study is to adapt the Fugl-Meyer assessment to Turkish culture and to test its validity and reliability in acute phase stroke patients.

NCT ID: NCT05809973 Recruiting - Stroke, Acute Clinical Trials

The Oslo Study of Visual Impairment After Stroke (StrokeVIS)

StrokeVIS
Start date: November 15, 2021
Phase:
Study type: Observational

Longitudinal, prospective, single-center observational study of visual impairment after stroke. Population: Patients admitted with acute ischemic stroke at the Regional Stroke Unit at Oslo University Hospital who are assessed to not have more serious neurological deficits than to be eligible for a prospective observational study of visual impairment. National Institute of Health Stroke Scale (NIHSS) will be used for screening of the patients eligible for the study with cut off of NIHSS 20. Based on the number of patients admitted to our center to include 120 patients in the StrokeVIS study. The study aims are: 1. To determine the prevalence of visual impairment in stroke patients in the acute phase and after 3 months. 2. To compare visual impairment in those treated with EVT and those not. 3. To determine the sensitivity and specificity of the Vision Screening Assessment (VISA) tool for detection of visual impairment in stroke patients. 4. To assess possible association between brain MRI lesions and visual impairment in stroke patients in the acute phase. 6) To assess any cognitive deficits at 3-month follow-up that could impact visual function. Inclusion criteria: 1. Acute ischemic stroke and NIHSS < 20 2. Age ≥18 years. 3. Written informed consent of the patient or oral informed consent witnessed by a doctor. Exclusion criteria: 1. NIHSS < 20 2. No willingness and ability of the patient to participate in all baseline and follow-up examinations. Duration of study participation: 3 months.

NCT ID: NCT05805644 Not yet recruiting - Stroke, Acute Clinical Trials

Robot Mediated Therapy-Upper Limb Outcomes in Stroke

Start date: June 1, 2023
Phase: N/A
Study type: Interventional

This study aims to determine the clinical outcomes of stroke patients who are provided with adjunctive robot-mediated task specific therapy(RMTT) and robot-mediated impairment training (RMIT) as compared to those who are provided with adjunctive RMIT.

NCT ID: NCT05804006 Recruiting - Stroke, Acute Clinical Trials

High-Intensity Interval Training in the Early Subacute Stroke With a Semi-recumbent Bike

Start date: December 1, 2022
Phase: N/A
Study type: Interventional

Although High-intensity interval training (HIIT) exercise has emerged in recent years as a powerful time-efficient alternative to moderate-intensity continuous cardiovascular exercise training (MICT) to enhance neuroplasticity, motor, and cognitive functions, its feasibility remains to be determined early after stroke. Our study aims to investigate the feasibility of the HIIT program and its effects on functional abilities, cognitive function, and quality of life in early post-stroke.

NCT ID: NCT05797792 Not yet recruiting - Stroke, Acute Clinical Trials

CHemical OptImization of Cerebral Embolectomy 2 (CHOICE 2).

CHOICE2
Start date: June 1, 2023
Phase: Phase 3
Study type: Interventional

Multi-center, randomized, parallel-group, superiority study to compare the efficacy of adjunct intra-arterial rt-PA versus not adjunct intra-arterial rt-PA in the improvement of the efficacy of mechanical thrombectomy in patients with large vessel occlusion acute ischemic stroke.

NCT ID: NCT05793177 Not yet recruiting - Stroke, Acute Clinical Trials

MONitoring Sedentary Behavior and Light Physical Activity in Patients With Stroke

MONSS
Start date: August 1, 2023
Phase: N/A
Study type: Interventional

This randomized control trial (RCT) aims to test the effect of a 12 weeks tailored behavioral intervention on stroke survivors living in the community and compare the results to a control group of stroke survivors participating in standard care. The intervention's purpose is to lower the time spend with sedentary behavior and raise the level of physical activity in stroke survivors throughout their everyday life. The intervention contains two motivational interviews with a focus on goal setting, action planning, motivation, fatigue management, and general information on life after stroke. The primary outcome for behavior change is objectively measured physical activity using an activity tracker (ActivPal4 Micro) and secondary glycohemoglobin and changes in quality of life.