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Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study — GREEN  

Stroke, Acute Clinical Trial

Official title:
Glenzocimab for REperfusion in the Setting of Endovascular Therapy for Brain infarctioN: GREEN Study

Clinical Trial Summary

Emergent reperfusion is the main goal for acute ischemic stroke therapy (AIS). Endovascular therapy (EVT) is recommended within 6 hrs of stroke onset, and up to 24 hrs following perfusion imaging criteria. Despite the major benefit associated with MT, more than 50% of the patients remain disabled at 3 months. Reperfusion rates after MT are critical to determine functional outcome. However, complete reperfusion is obtained in only 50 % of the patients, due to, at least in part, erratic emboli and/or no-reflow processes. The aim of this study is to evaluate the efficacy of glenzocimab in addition to EVT and compared to EVT plus placebo, whether or not associated with ntravenous thrombolysis (IVT), on functional outcome at day 90.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05559398
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact mikael Mazighi, MD PHD
Phone 1 49 95 25 97
Email mikael.mazighi@aphp.fr
Status Not yet recruiting
Phase Phase 2/Phase 3
Start date October 10, 2022
Completion date October 10, 2026
View Details
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