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Periodontitis clinical trials

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NCT ID: NCT04129684 Recruiting - Periodontitis Clinical Trials

A Clinical Trial to Evaluate the Effectiveness of Lactobacillus Reuteri for Periodontitis in a Chinese Population

Start date: December 1, 2019
Phase: N/A
Study type: Interventional

The aim of this study is to determine the efficacy of application of Lactobacillus Reuteri probiotics therapy on clinical improvement and on microbial shift in Chinese periodontitis patients.

NCT ID: NCT04127487 Recruiting - Clinical trials for Coronary Artery Disease

Quantification of NLRP3 (rs4612666) and CARD8 Gene (rs2043211) in Generalized Chronic Periodontitis Subjects

Start date: October 1, 2019
Phase:
Study type: Observational

Quantification of NLRP3 (rs4612666) and CARD8 (rs20432111) will be analysed in the subgingival plaque and blood samples of generalized chronic periodontitis with and without coronary heart disease. The demographic and the periodontal parameters were assessed and correlated with the quantification of NLRP3 (rs4612666) and CARD8 (rs2043211) was analysed with RT-PCR

NCT ID: NCT04127474 Recruiting - Clinical trials for Coronary Heart Disease

Expression of Trefoil Factors and Adrenomedullin in Subjects With Chronic Periodontitis and Coronary Heart Disease

Start date: October 14, 2019
Phase:
Study type: Observational

To assess the demographic variables, periodontal parameters and to determine the expression of Trefoil factors 2 and 3 and Adrenomedullin in unstimulated saliva samples of periodontally healthy subjects with coronary heart disease and generalised chronic periodontitis subjects with and without coronary heart disease.

NCT ID: NCT04069611 Recruiting - Diabetes Clinical Trials

Non Surgical Therapy of Periodontitis in Diabetes Patients: the Adjunctive Use of Probiotics

ProDiabet
Start date: January 30, 2020
Phase: N/A
Study type: Interventional

The aim of this study is to evaluate the clinical and microbiological performance of a probiotic formulation (Sunstar GUM Periobalance) as adjunctive to non-surgical periodontal therapy in patients with diabetes. The null hypothesis is that the adjunctive use of this probiotic formulation would not have any additional benefit over scaling and root planning in the number of residual pockets or in the microbiological impact of the treatment. Conversely, the alternative hypothesis is that the adjunctive use of this formulation would improve the clinical results of non-surgical periodontal therapy when compared to scaling and root planing alone, through a modification of the subgingival biofilm composition.

NCT ID: NCT04046237 Recruiting - Clinical trials for Acute Myocardial Infarction

Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)

PAROCARD
Start date: August 2, 2019
Phase: N/A
Study type: Interventional

Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group versus treatment by dental surgeons as part of their usual practice in the control group. For the intervention group, periodontal management will be carried out for a maximum of 6 months after randomisation, prolonged by a follow-up of 6 months including a maintenance visit at M9. All patients will have an FDG-PET at M0 and M12 for evaluation of inflammation on carotid atherosclerotic plaques.

NCT ID: NCT03997578 Recruiting - Periodontitis Clinical Trials

Non-incised Papillae Surgical Approach (NIPSA) and Connective Tissue Graft Plus Emdogain for Periodontal Defects

Start date: September 3, 2019
Phase: N/A
Study type: Interventional

The present study pretends to show the results of combining a modification of the Non-incised papillae surgical approach (NIPSA) attempting to improve the outcome in the treatment of teeth with advanced periodontal support loss.

NCT ID: NCT03997552 Recruiting - Periodontitis Clinical Trials

NIPSA Versus Marginal Approach by Palatal Incision and MIST in Periodontal Regeneration

Start date: September 6, 2019
Phase: N/A
Study type: Interventional

Three techniques for periodontal reconstruction will be compared, in which marginal access versus apical access will be carried out.

NCT ID: NCT03995615 Recruiting - Clinical trials for Periodontitis and Rheumatoid Arthritis

ESTIMATION OF GINGIVAL CREVICULAR LEVEL OF YKL40

Start date: January 2020
Phase: N/A
Study type: Interventional

The presence of YKL- 40 an acute phase protein in both chronic periodontitis and rheumatoid arthritis. However, till date no studies has been done on the levels of gingival crevicular fluid YKL-40 following scaling and root planing, the present study which is first of its kind is designed to detect and estimate the gingival crevicular fluid YKL-40 levels in healthy patients, chronic periodontitis and patient with chronic periodontitis having rheumatoid arthritis at baseline and chronic periodontitis having rheumatoid arthritis 6 weeks post periodontal therapy (scaling and root planning [SRP]). This could throw more light on it and extend our knowledge on its role in both the conditions.

NCT ID: NCT03863249 Recruiting - Clinical trials for Chronic Periodontitis

Use of the xCELLigence System for Quantification of Bacterial Biofilm's Real Time Formation and Antibiotics Selection.

Start date: February 8, 2019
Phase: Phase 4
Study type: Interventional

The aim of the study is to develop an in vitro model of growth of oral biofilms, and validate xCELLigence system for the selection of an effective antibiotic treatment for each patient.

NCT ID: NCT03797807 Recruiting - Periodontitis Clinical Trials

Minimally-invasive Non-surgical and Surgical Periodontitis Treatment

Start date: March 20, 2019
Phase: N/A
Study type: Interventional

To compare the efficacy of a modified minimally-invasive non-surgical periodontal therapy (MINST) approach with a surgical approach (M-MIST) in determining bone and clinical attachment changes in intrabony defects