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Overweight clinical trials

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NCT ID: NCT05430542 Completed - Metabolic Syndrome Clinical Trials

Age-related Post-lockdown BMI Variations

COVIDLOCKMET01
Start date: May 15, 2020
Phase:
Study type: Observational [Patient Registry]

The COVID-19 lockdown has represented an inedited model of increased metabolic risk in all age groups, due to negative changes in dietary habits, physical activity, lifestyle. These effects have been generally explored at a population level in distinct age groups. Potential intra-familial, specific effects in adults and children sharing the same socio-economic, cultural level and living habits have been scarcely explored. We aimed to extend the previous observations concerning anthropometric data at the intra-familial level. In particular, we prospectively characterized the variations in lifestyle habits and related outcomes over a 2 two months COVID-19 lockdown period, exploring both parents and their children. A cohort of 149 couple parent/children were prospectively enrolled. By a validated questionnaire we explored changes of Body Mass Index (BMI) and individual lifestyle during a 2-month lockdown.

NCT ID: NCT05428137 Not yet recruiting - Obesity Clinical Trials

Study of Safety and Efficacy of a Probiotic and Postbiotic in Overweight Individuals

KOBI
Start date: June 2022
Phase: N/A
Study type: Interventional

Investigate the effect of a probiotic (live bacteria) and postbiotic (heat-treated bacteria) strains in overweight individuals.

NCT ID: NCT05426525 Not yet recruiting - Clinical trials for Overweight and Obesity

Use of Empagliflozin to Treat Prediabetes

Start date: June 2022
Phase: Phase 4
Study type: Interventional

The overall purpose of this study is to identify how empagliflozin (a drug commonly used to treat type 2 diabetes) impacts skeletal muscle metabolic health among adults with prediabetes. Our aims are to: 1) Test the ability of empagliflozin to improve regulation of glucose metabolism (i.e., blood sugar) among overweight and obese individuals with prediabetes, and 2) Identify mechanisms to explain how empagliflozin may improve skeletal muscle glucose metabolism. We hypothesize empagliflozin will improve regulation of glucose metabolism due to changes in whole-body and skeletal muscle metabolism (e.g., increased rates of whole-body fat oxidation, evidence of impaired skeletal muscle mitochondrial respiratory function and increased energetic stress, lower accumulation of skeletal muscle lipids and improved skeletal muscle insulin signaling compared with placebo treatment).

NCT ID: NCT05424094 Not yet recruiting - Clinical trials for Overweight and Obesity

HRQoL in Overweight and Obese Children/Adolescents

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

The primary aim of the present study is to record changes in the health-related quality of life (HRQoL) of children/adolescents participating in the multi-professional group programme 'kinderleicht' in 2022 over the course of the eleven-month active phase. In addition, these data will be examined for correlation with changes in BMI, waist and hip circumference, and motor performance. Secondarily, the study addresses the questions of whether the recording of HROoL by means of the KINDL questionnaire is practicable for the programme leaders and what benefit can be gained from the analysed data for future cohorts.

NCT ID: NCT05423015 Completed - Childhood Obesity Clinical Trials

Assessment of the Effects of Synbiotic on Gut Microbiota Composition in Scholars With Overweight

Start date: July 21, 2017
Phase: N/A
Study type: Interventional

This study was a randomized, double-blind controlled protocol in children overweight aged 6-11 years. This study aimed to evaluate the effect of consuming fermented milk products containing Lactobacillus casei strain Shirota (LcS), as a probiotic enriched with prebiotic fructans from A. salmiana or inulin-like standard commercial prebiotic to improve the gut microbiota modulation. After providing detailed information, written informed consent was obtained from parents and written and oral assent from participants before the initial test day. Children were eligible for inclusion in the trial if they were overweight according to the World Health Organization (≥85th body mass index (BMI) percentile for overweight). The trial took place in three full-time elementary schools in San Luis Potosí, México, and the screening of the prospective participants took place up to 1 week prior to the randomization. Children were evaluated over a 6-week intervention period receiving different fermented milk products

NCT ID: NCT05422391 Recruiting - Obesity Clinical Trials

The Acute Effects of Caloric Restriction on Anthropometrics, Metabolism, and Cardiovascular Health in Overweight Adults

Start date: June 7, 2022
Phase: N/A
Study type: Interventional

The purpose of this study is to document the efficacy of a 3 day intermittent fasting/caloric restriction (IF/CR) using the Plexus® 3 day reset program on body weight as well as regulatory parameters of metabolism and metabolic flexibility. This study will provide data on the acute efficacy regarding the program but also identify the potential underlying physiological mechanisms through which the dietary intervention may elicit improvements, and the participant experience of the program. Collectively, this will provide a window into the possible adaptations with a longer-term dietary intervention.

NCT ID: NCT05419063 Not yet recruiting - Clinical trials for Overweight and Obesity

Accessible Weight Loss for Adults With Low Vision: A Feasibility Study

Start date: June 6, 2022
Phase: N/A
Study type: Interventional

This study will examine the feasibility of an all-remote approach to enrollment in and implementation of an 8-week weight loss program for adults with low vision. The weight loss program will provide asynchronous support (information, automated texting feedback, tailored emails) for adopting and maintaining lifestyle-based strategies for safe and effective weight loss.

NCT ID: NCT05410353 Not yet recruiting - Clinical trials for Overweight and Obesity

Choosing Healthy Activities and Lifestyle Management Through Portal Support

CHAMPS
Start date: January 2023
Phase: N/A
Study type: Interventional

The study aims to randomize 250 participants to 1 of 2 arms: a.) an Active Intervention Group (based on the Look AHEAD* ILI) or b.) a Comparison Group (based on the Look AHEAD DSE Comparison group) to test the hypothesis that a multicomponent, multilevel behavioral weight loss intervention (Active Intervention Group) adapted for underserved groups and delivered through Health Information Technology (Health IT) tools via the Electronic Health Record (EHR) patient portal, will result in significantly greater weight loss 12 months after enrollment compared to the Comparison Group. *The Look AHEAD study was a multi-center, randomized clinical trial involving overweight and obese persons with type 2 diabetes, aimed to determine the effects on the cardiovascular outcomes of an intensive lifestyle intervention (ILI) for weight loss, in comparison to the diabetes support and education intervention (DSE).

NCT ID: NCT05405244 Completed - Clinical trials for Overweight and Obesity

Examination of Bromocriptine on Homeostatic and Hedonic Mechanisms of Food Intake in Individuals at High Risk for T2DM

Start date: September 19, 2017
Phase: Phase 3
Study type: Interventional

The current project applies an integrative three-prong approach to investigate the potential of the dopamine D2 receptor (DRD2) agonist bromocriptine to: 1) increase homeostatic satiation signaling, 2) alter neural circuitry to reduce hedonically motivated food intake, and 3) examines a genetic predisposition that may markedly impact the effectiveness of this medication in those at high risk for T2DM.

NCT ID: NCT05404711 Not yet recruiting - Insulin Resistance Clinical Trials

Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation

Start date: July 2022
Phase: N/A
Study type: Interventional

The purpose of this research study is to determine whether continuous glucose monitors (CGM) are a safe, effective, and acceptable way to evaluate type 2 diabetes risk in youth as compared to the standard 2-hour oral glucose tolerance test (OGTT). This study will involve wearing a CGM, wearing a physical activity tracker, responding to surveys, and completing at-home glucose and mixed food challenge while wearing the CGM. Subjects will also be asked to complete an interview by phone or videoconference after wearing the CGM.