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Overweight clinical trials

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NCT ID: NCT03661879 Not yet recruiting - Obesity Clinical Trials

Research Study of a New Medicine (NNC9204-1706) in People With Overweight or Obesity

Start date: September 12, 2018
Phase: Phase 1
Study type: Interventional

The study is testing a new medicine for weight control in people with overweight or obesity. The aim of the study is to find out how safe the study medicine is and how it works in the body. Participants will either get NNC9204-1706 (the new study medicine) or placebo (a dummy medicine) - which treatment participants get is decided by chance. NNC9204-1706 is a new medicine which cannot be prescribed by doctors. Participants will get an injection under the skin of participants' stomach each morning for 10 weeks. A medical tool called NovoPen®4 will be used for the injection. Participants must change the part of the pen including the medicine (the cartridge) each day. The study will last for about 16 weeks. Participants will have at least 17 clinic visits and 10 phone calls with the study doctor. At certain times during the study, participants will have blood drawn and 3 different kinds of heart tests (electrocardiograms). Study doctor will ask participants to answer mental health surveys.

NCT ID: NCT03661177 Not yet recruiting - Obesity Clinical Trials

Reclaiming Indigenous Food and Health

Start date: September 2019
Phase: N/A
Study type: Interventional

The overall purpose of this proposed action-research project is to measure the feasibility of consuming and the impact of indigenous plants and foods on health outcomes among Native American participants.

NCT ID: NCT03657186 Recruiting - Overweight Clinical Trials

Study to Evaluate Benefit of ProbioSatys™ on Weight Reduction in Overweight Subjects

Start date: August 31, 2018
Phase: N/A
Study type: Interventional

The study aims to evaluate the effects of ProbioSatys™ on body weight and related parameters in overweight subjects during a 12-week consumption period. In addition, tolerability and safety of ProbioSatys™ will be assessed.

NCT ID: NCT03653559 Enrolling by invitation - Clinical trials for Overweight and Obesity

Effect of Consuming "Home Meals" on Body Weight

Start date: January 15, 2018
Phase: N/A
Study type: Interventional

The current epidemic of obesity relates to the transition from traditional to industrialised diets. The present project investigates the effect on body energy of recommending the consumption of traditional "home meals", which may be a useful recommendation against obesity. A randomized controlled trial design is applied assigning participants to a recommendation of consuming during 12 weeks either "home meals" or "healthy meals." Frequency of consumption of energy-dense foods and of exercise is monitored throughout the intervention; weight and body fat are measured at baseline and at four-week intervals. The hypothesis is that consuming more frequently "home meals" reduces at least as much weight and adiposity as "healthy meals".

NCT ID: NCT03652532 Completed - Obesity Clinical Trials

Alternate Day Fasting and Exercise in Overweight or Obese Adults

Start date: April 10, 2014
Phase: N/A
Study type: Interventional

Alternate day fasting is known to be helpful to control weight and have a positive effect on insulin resistance and cardiovascular risk factors. However, there have been no studies on weight reduction program combining alternate day fasting with exercise which preserves lean mass in Korea. The purpose of this randomized clinical trial is to examine the effects of alternate day fasting and exercise on weight reduction, visceral fat, and metabolic parameters in overweight or obese adults.

NCT ID: NCT03652207 Completed - Clinical trials for Overweight and Obesity

Effects of Palatinose™ on Weight Management and Body Composition

Start date: April 20, 2009
Phase: N/A
Study type: Interventional

The study aims to assess body weight and body composition changes in overweight and obese persons consuming an energy-reduced diet containing foods with either sucrose or isomaltulose (Palatinose(TM)) over a period of 3 months.

NCT ID: NCT03651622 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 1

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

Start date: September 2018
Phase: N/A
Study type: Interventional

An initial pilot and feasibility study will be conducted using a Sequential, Multiple Assignment, Randomized Trial (SMART) design to identify acceptable and effective dietary strategies to optimize both glycemic control and weight management in young adults with Type 1 diabetes (T1D). This pilot trial will include a ten-and-a-half month behavioral intervention, with co-primary outcomes of glycemic control (HbA1C and hypoglycemia) and weight loss. The pilot trial will assess acceptability and adherence to three distinct, evidence-based dietary approaches designed to address weight management and glycemic control. Behavioral counseling strategies, use of carbohydrate counting for insulin dosing, and encouragement of physical activity will be the same across the three dietary approaches.

NCT ID: NCT03650088 Not yet recruiting - Clinical trials for Diabetes Mellitus, Type 2

Adaptation of a Digital Weight Loss Intervention Promoting Self-regulation for Use in Type 2 Diabetes

Start date: October 2018
Phase: N/A
Study type: Interventional

The purpose of this study is to 1) conduct a formative evaluation with patients and providers to a) review intervention features in a weight loss app that the Tate team has previously developed to promote PA and diet and adapt them to the needs and perspectives of those with Type 2 Diabetes (T2DM), and b) explore feasibility and acceptability of daily monitoring of BG using continuous monitoring (CGM), self-monitoring of diet using the simplified system, appropriate displays of data to facilitate comprehension and decision making, inform updates to weight loss intervention materials to meet the needs of this patient population, 2) develop the modified intervention and 3) conduct a pilot and feasibility study on short-term impacts of the intervention in overweight adult patients with T2DM not treated with medications in preparation for an R01 submission.

NCT ID: NCT03648892 Recruiting - Obesity Clinical Trials

Brain Dopamine Function in Human Obesity

Start date: September 19, 2018
Study type: Observational

Background: Dopamine is a natural chemical in the brain that may influence eating behavior and physical activity. Researchers want to measure the brain s dopamine activity and understand how it differs in people with obesity. Objective: To better understand how brain function, particularly dopamine activity, relates to body weight and eating behavior. Individuals may be able to participate if they: Have a BMI of at least 18.5 kg/m2 Are weight-stable and generally healthy Are between ages 18-45 years Have normal blood pressure Are not using illegal drugs (based on urine drug screen) Are not following a special diet Do not have metal implants Design: Participants will be screened with: - Medical history - Physical exam - Questionnaires and an interview to see if it is safe to have a PET/MRI scan - Fasting blood and urine tests - Participants will eat a special diet given to them for the 5 days before their inpatient visit. Participants will have a 5-day inpatient visit. Some days include blood and urine tests. Each day includes surveys and tests to measure habits and likes/dis-likes. A sample schedule may be: Day 1: Participants will wear a monitor that uses a needle below the skin to measure glucose. Their body fat will be measured with low-dose x-rays Day 2: Participants will have a PET scan. They will lie on a table that slides in and out of a donut-shaped scanner. They will be injected with a small amount of a radioactive substance and wear a cap on their head. Day 3: Participants will have an MRI. They will lie on a table that slides in and out of a scanner. Day 4: Participants will have another PET scan. This time, they will drink a milk shake during a break from the scanner. Then, they will go back inside the scanner for the end of their scan. Day 5: Participants will wear a hood for up to 40 minutes to measure their breathing. They will also drink special water and collect samples of their urine to measure the rate they burn energy. For 12 months after the visit, participants will track their weight and physical activity daily using a special scale and activity monitor. A few times over the year, the study team will send participants special activity monitors to use for 7 days at a time. Participants will have an in-person 1-day follow-up visit. This includes most tests except for PET scanning.

NCT ID: NCT03647007 Not yet recruiting - Overweight Clinical Trials

Short- and Long-term Health Effects of a Residential Stay in a Danish Christmas Seal Home.

Start date: September 11, 2018
Phase: N/A
Study type: Interventional

The purpose of the study is: (1) to evaluate the short-term effects of a 10-week residential stay in a Danish Christmas Seal Home on health, physical fitness, physical activity level, learning, sleep and well-being; (2) to investigate the long-term effects 3 and 12 months after the stay; and (3) to examine whether a special effort involving a high-intensity activity/health education programme (FIFA 11 for Health) increases the effects on physical fitness and health knowledge, learning capabilities, sleep patterns, well-being and adherence to a physically active lifestyle compared to the standard programme.