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Overweight clinical trials

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NCT ID: NCT03805295 Completed - Quality of Life Clinical Trials

Implementation and Evaluation of a Before School Physical Activity Program in Revere, MA

Start date: February 16, 2018
Phase: N/A
Study type: Interventional

This study evaluates the implementation of the BOKS program in three schools (K-8) in Revere, MA, and its effect on participating students with regard to BMI, cognitive, and quality of life outcomes. BOKS (Build Our Kids' Success) is a before-school physical activity program that has been implemented in over 2,000 elementary and middle schools. Two sessions will be held (Spring 2018 and Winter 2018. This is a cohort study evaluating the impact of program participation on child BMI, quality of life, and executive function.

NCT ID: NCT03802253 Not yet recruiting - Clinical trials for Impaired Fasting Glucose

Time Restricted Feeding on Impaired Fasting Glucose(TRIG Trial)

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

We evaluated the effects of Time-Restricted Feeding (TRF) regimen on impaired fasting glucose in comparison with overweight/obese patients receiving standard of care over 12 months.

NCT ID: NCT03800823 Recruiting - Obesity Clinical Trials

Overweight and Obesity in Preschoolers

Start date: January 15, 2019
Phase: N/A
Study type: Interventional

Obesity interventions in early childhood are recommended as they have been proven to be more effective than interventions later in life. The overall aim of this study is to assess the effectiveness, feasibility, and acceptance of an overweight and obesity intervention in socially disadvantaged families. Participants will be families with children aged 2-6 years (n = 300) with overweight or obesity and will be recruited from three sites: Stockholm, Sweden (n = 100); Timisoara, Romania (n = 100); and Mallorca, Spain (n = 100).

NCT ID: NCT03799146 Active, not recruiting - Overweight Clinical Trials

Identifying the Effect and Working Mechanisms of MyPlan 2.0 in Older Adults

Start date: January 15, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to investigate whether and how 'MyPlan 2.0' helps older adults to be more physically active or less sedentary. Two groups will be created, an intervention group and a waiting-list control group.

NCT ID: NCT03792685 Recruiting - Clinical trials for Diabetes Mellitus, Type 2

Looking for Personalized Nutrition for Obesity/Type 2 Diabetes Mellitus Prevention

Start date: September 24, 2009
Phase: N/A
Study type: Interventional

The objectives of this trial are to assess the effects of interactions between genetic factors and diet with various macronutrient intake on the metabolic disorders, obesity and type 2 diabetes risk, prevention, development and progress.

NCT ID: NCT03792282 Recruiting - Clinical trials for Overweight and Obesity

Time-Restricted Feeding(TRF) on Overweight/Obese Women With Polycystic Ovarian Syndrome (PCOS)

Start date: January 7, 2019
Phase: N/A
Study type: Interventional

The aims of the present study is to examine whether Time-Restricted Feeding (TRF) is a safe and effective regimen to improve insulin resistance and decrease body weight in overweight/obese Polycystic ovary syndrome (PCOS) patients over 16 weeks compared to reduced energy restriction.

NCT ID: NCT03787225 Not yet recruiting - Obesity Clinical Trials

A Research Study of How NNC0174-0833 Behaves in Japanese and Caucasian Volunteers Who Are Normal Weight, Overweight or With Obesity

Start date: January 2, 2019
Phase: Phase 1
Study type: Interventional

The aim of this study is to look at how the study medicine behaves in the participant's body and how it is removed from the participant's body. The study compares Japanese and Caucasian people who are normal weight, overweight or with obesity. The participants will either get NNC0174-0833 (a potential new medicine) or placebo (a "dummy" medicine similar to the study medicine but without active ingredients) - which treatment any participant gets is decided by chance. Participants will get 1 injection by a study nurse at the clinic. The injection will be with a needle in a skin fold in the participant's stomach area. The study will last for about 4 months, but duration of participation for any participant will last up to about 2 months. The participants will have 8 clinic visits with the study staff.

NCT ID: NCT03787108 Recruiting - Clinical trials for Non-Alcoholic Fatty Liver Disease

Measuring Fatty Liver With Ultrasound and MRS in Children With Overweight or Obesity

Start date: December 24, 2018
Study type: Observational

Obesity is associated with a variety of comorbidities, amongst which non-alcoholic fatty liver disease (NAFLD). A recent meta-analysis has shown that the prevalence of NAFLD in obese pediatric populations is around 35%, compared to approximately 8% in general pediatric populations, making it a very important health threat in these populations. The golden standard for diagnosis of NAFLD is liver biopsy. However, since liver biopsy is associated with a certain risk of morbidity and mortality, this method is inappropriate for screening large populations at-risk for developing NAFLD. Magnetic resonance spectroscopy has demonstrated excellent correlation with liver biopsy and the is the most accuratete non-invasive method to measure liver fat content in children. However, MRS is expensive and not available in all centres. A novel ultrasonographic measurement to quantitatively assess liver steatosis is the hepatorenal index (HRI). Previous studies have shown high sensitivity and specificity of the HRI, as compared to MRS and liver biopsy. However, this measurement has never been validated in children. In this study, the HRI will be compared to MRS in children with obesity, to validate the HRI and to determine cut-off points.

NCT ID: NCT03777189 Recruiting - Clinical trials for Overweight and Obesity

Cognitive-Behavioral and Physical Activity Interventions for Binge Eating and Overweight

Start date: December 5, 2018
Phase: N/A
Study type: Interventional

This study aims to perform an open-series pilot trial to examine the efficacy of cognitive-behavioral therapy delivered in a guided self-help format (CBTgsh) with added content related to physical activity (PA), for the treatment of binge-eating disorder (BED), operationalized as BED full diagnostic criteria or BED with the full criteria except for the binge episode size criterion.

NCT ID: NCT03775278 Not yet recruiting - Clinical trials for Otherwise Healthy Overweight or Obese

A Study of Safety, Tolerability, and Pharmacokinetics of Multiple-Ascending Doses of PHP-303 in Otherwise Healthy Overweight or Obese Subjects

Start date: December 2018
Phase: Phase 1
Study type: Interventional

This is a Phase 1, randomized, double-blind, placebo-controlled multiple-ascending dose (MAD) study designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of PHP-303 in otherwise healthy overweight or obese volunteer subjects. Within each ascending dose cohort, subjects will be randomized in a 4:1 ratio to receive PHP-303 or placebo. The primary objective is to establish the safety and tolerability and maximum tolerated dose (MTD) of orally-administered PHP-303.