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Overweight and Obesity clinical trials

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NCT ID: NCT06348771 Recruiting - Clinical trials for Overweight and Obesity

Postprandial Inflammation and Nuts (PIN) in Older Adults

PIN
Start date: March 25, 2024
Phase: N/A
Study type: Interventional

The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice, but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain and inflammation. Given these findings, this study will examine the postprandial effects of meals with 2 levels of saturated fatty acids (SFA) on metabolic endotoxemia, inflammation and satiety, using a randomized cross-over design. The low SFA meal includes peanuts that are high in monounsaturated fatty acids (MUFA) and this will be compared to a high SFA meal. The results of this study have the potential to provide valuable insights into the role of peanuts in promoting health and preventing disease in at-risk older adults.

NCT ID: NCT06347484 Recruiting - Stroke Clinical Trials

Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)

CONNECT
Start date: May 4, 2024
Phase: N/A
Study type: Interventional
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NCT ID: NCT06344377 Not yet recruiting - Clinical trials for Overweight and Obesity

Betaine Supplementation and Lipid Metabolism in Overweight and Obese Pre-menopausal Women

Start date: April 21, 2024
Phase: N/A
Study type: Interventional
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NCT ID: NCT06338709 Not yet recruiting - Clinical trials for Overweight and Obesity

Clinical Study Protocol for the Assessment of Safety and Efficacy of the BARICLIP®

Start date: September 2024
Phase: N/A
Study type: Interventional
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NCT ID: NCT06333496 Active, not recruiting - Obesity Clinical Trials

Effect of a Glucagon Like Peptide 1 (GLP1) Booster in Healthy Humans

Start date: January 2, 2024
Phase: N/A
Study type: Interventional

BACKGROUND GLP1 booster (GB) was designed to stimulate the endogenous production of GLP1, which in turn releases insulin, controls blood glucose level, suppresses appetite and thus helps people lose weight. PURPOSE The purpose of this study is to assess several clinical endpoints and questionnaires in healthy volunteers taking the new GB formula. SCOPE The scope of this protocol covers the non-clinical portion as well as the assessment of several clinical endpoints and questionnaires. In brief, the non-clinical design will be an open-label study involving volunteers taking GB everyday for 12 weeks. Data analysis will involve measuring the clinical endpoints across the group at different timepoints.

NCT ID: NCT06323070 Recruiting - Clinical trials for Overweight and Obesity

Effects of Watermelon or Low-fat Cookie Consumption on Wellness

Start date: March 1, 2024
Phase: N/A
Study type: Interventional

The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.

NCT ID: NCT06322940 Not yet recruiting - Clinical trials for Overweight and Obesity

Effect of Dairy Product Matrices on Insulin Resistance in People With Overweight and Obesity and Prediabetes

Start date: September 1, 2024
Phase: N/A
Study type: Interventional

The objective of the study is to determine the effect of dairy product matrices on insulin sensitivity in overweight and obese adults with prediabetes. Females and males (30-65 y) will be recruited from the greater Montreal area. Upon screening, those with prediabetes will complete a 2-wk run-in period in which participants will consume 1 serving/d of regular-fat dairy products (milk, yogurt, or cheese). Adherent participants will be randomized by sex into 1 of 3 groups: ≤1 serving/d of dairy (limited dairy) or 2-3 servings/d of reduced-fat or regular-fat dairy for 12 weeks. Participants will be instructed on how to incorporate foods into their diet to prevent changes in their body weight. The hyperinsulinemic-euglycemic clamp will be used before and after the intervention to document potential changes in insulin sensitivity as the primary outcome. In addition, glycemic variables, body composition, and cardiometabolic risk factors will be assessed as secondary outcomes. Adherence to intervention will be assessed at each visit by food diaries and a record of consumed dairy products.

NCT ID: NCT06311487 Recruiting - Healthy Clinical Trials

Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

TANDEM
Start date: April 15, 2024
Phase: N/A
Study type: Interventional

This study plans to learn more about metabolic responses to aerobic exercise at different times of the day (morning or evening) under fasting versus fed conditions.

NCT ID: NCT06302231 Not yet recruiting - Obesity Clinical Trials

Effects of Time-restricted Eating and Aerobic Exercise Training in Women With Overweight and Obesity

Start date: March 2024
Phase: N/A
Study type: Interventional

Time-restricted eating (TRE) is a dietary approach that aims to increase fasting time and decrease the eating window. Promising TRE effects on weight loss and improvements in some cardiometabolic risk factors have been reported in studies in animals and humans. However, the impacts of TRE combined with aerobic exercise training in individuals with overweight and obesity have been insufficiently investigated. Additionally, aerobic training performed in a fasted state appears to promote physiological adaptations that may improve the metabolic health in individuals with overweight and obesity. The present study investigates the effects of 8 weeks of TRE associated with aerobic training in a fasted state versus a fed state on body composition and cardiometabolic parameters in women with overweight and grade 1 obesity.

NCT ID: NCT06282952 Not yet recruiting - Clinical trials for Overweight and Obesity

NEwborn Infant of a Mother With Obesity - Fecal Microbiome Transplantation, RCT

NEMO-FMT
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to investigate the differences in microbiota, height and weight between infants born by cesarean section to obese mothers and randomized to receive fecal microbiota transplant after birth. The main questions it aims to answer are: - Could fecal transplant be used improve gut microbiota and prevent overweight or obesity. - Is the source of colonization a modifiable factor and can it be changed by using an early fecal microbiota transplant.